3 results match your criteria: "Guangdong Medical College No. 1 Xincheng Road[Affiliation]"
Elevated serum IL-35 and increased expression of IL-35-p35 or -EBI3 in CD4(+)CD25(+) T cells in patients with active tuberculosis.
Am J Transl Res
May 2016
Guangdong Provincial Key Laboratory of Medical Molecular DiagnosticsNo. 1 Xincheng Road, Dongguan 523808, China; Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical CollegeNo. 1 Xincheng Road, Dongguan 523808, China.
Despite the recent appreciation of interleukin 35 (IL-35) function in inflammatory diseases, little is known for IL-35 response in patients with active tuberculosis (ATB). In the current study, we demonstrated that ATB patients exhibited increases in serum IL-35 and in mRNA expression of both subunits of IL-35 (p35 and EBI3) in white blood cells and peripheral blood mononuclear cells. Consistently, anti-TB drug treatment led to reduction in serum IL-35 level and p35 or EBI3 expression.
View Article and Find Full Text PDFElevated HMGB1-related interleukin-6 is associated with dynamic responses of monocytes in patients with active pulmonary tuberculosis.
Int J Clin Exp Pathol
March 2016
Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics 1 Xincheng Road, Dongguan 523808, People's Republic of China ; Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College No. 1 Xincheng Road, Dongguan 523808, People's Republic of China.
Article Synopsis
- The study investigated the role of HMGB1 in patients with active pulmonary tuberculosis (APTB) by measuring its levels in plasma and sputum, along with various inflammatory cytokines and immune cells.
- Results showed that APTB patients had significantly higher levels of HMGB1 and cytokines (IL-6, IL-10, and TNF-α) compared to healthy volunteers, indicating an association with inflammation.
- The findings suggest that HMGB1 could serve as a potential biomarker for diagnosing and predicting the prognosis of APTB, reflecting the inflammatory state of monocytes in these patients.
BTLA exhibits immune memory for αβ T cells in patients with active pulmonary tuberculosis.
Am J Transl Res
October 2014
Department of Clinical Immunology, Institute of Clinical Laboratory Medicine, Guangdong Medical College No. 1 Xincheng Road, Dongguan 523808, China ; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics No. 1 Xincheng Road, Dongguan 523808, China.
Despite past extensive studies, the role of B and T lymphocyte attenuator (BTLA) in αβ T cells in patients with active pulmonary tuberculosis (ATB) remains poorly understood. Here we demonstrate that BTLA expression on αβ T cells is decreased in patients with M. tuberculosis (Mtb) infection.
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