In-situ layer-by-layer synthesized TpPa-1 COF solid-phase microextraction fiber for detecting sex hormones in serum.

The secretion disorder of sex hormones is the source that leads to the occurrence of many diseases such as polycystic ovarian syndrome (PCOS), hyperandrogenism and so on. There exist physiological changes in human body when slight fluctuations in concentrations of sex hormones happen. Therefore, it's of great significance for accurate detection of sex hormones in human body.

Ultrasound-assisted catalytic reduction of Cr(VI) by an acid mine drainage based nZVI coupling with FeS system from aqueous solutions: Performance and mechanism.

Nowadays, nanoscale zero valent iron (nZVI) has been extensively applied for the decontamination of various pollutants, but passivation of nZVI severely affects its reactivity in use. In this study, ultrasound (US)-assisted catalytic reduction of Cr(VI) by an acid mine drainage based nZVI (AMD-nZVI) coupling with FeS system was systematically examined. Results show that the presence of FeS and US induced a synergistic enhancement of Cr(VI) removal by AMD-nZVI.

A Boron Dipyrromethene-Based Fluorescence 'OFF-ON' Probe for Sensitive and Selective Detection of Palladium(II) Ions and Its Application in Live Cell Imaging.

A novel boron dipyrromethene (BODIPY)-based fluorescent probe BDP-Pd was designed and synthesized. Upon coordination with Pd , the emission of the probe at 508 nm significantly increased, showing an 'OFF-ON' fluorescence response. The complexation of BDP-Pd with Pd in both acetonitrile and aqueous solution were then studied by absorption and fluorescence spectra.

The fabrication of a covalent triazine-based organic framework for the solid-phase extraction of fourteen kinds of sulfonamides from meat samples.

A novel covalent triazine-based organic framework (CTF), SCAU-2, was fabricated and used as an adsorbent for the solid-phase extraction of fourteen kinds of sulfonamides (SAs) from meat. Another CTF, SCAU-1, was adopted as a comparison material, as it has a similar motif. A series of structural characterization steps was carried out on the synthesized materials and several parameters were investigated during the extraction process, including the amount of adsorbent, the dilution ratio, the pH of the sample, and the washing and elution solvents.

Adsorption and desorption characteristics of polyphenols from Oliv. leaves with macroporous resin and its inhibitory effect on α-amylase and α-glucosidase.

Background: Oliv. (EUO) was a traditional Chinese herb, its leaves were abundant in China, and polyphenol compounds were considered to be an important active ingredient in Oliv. leaves (EUOL).

Luteolin attenuates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via suppression of inflammation response.

Psoriasis is considered as a common chronic immune-mediated skin disorder characterized by abnormal keratinocyte proliferation. Luteolin, an anti-inflammatory natural flavonoid with well-accepted inhibition effect against keratinocyte proliferation, was hypothesized to have a potential therapeutic effect for psoriasis. In this paper, we investigated the relieving effect of luteolin against imiquimod-induced psoriasis-like lesions on BALB/c mice and its possible anti-inflammatory mechanisms in lipopolysaccharide-stimulated macrophages (RAW264.

Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).

The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to more than 20 million people infected worldwide with an average mortality rate of 3.6%. This virus poses major challenges to public health, as it not only is highly contagious but also can be transmitted by asymptomatic infected individuals.

In situ detection and imaging of lysophospholipids in zebrafish using matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry.

In this paper, a matrix-assisted laser desorption/ionization (MALDI) Fourier transform ion cyclotron resonance (FTICR) mass spectrometry (MS) (MALDI-FTICR-MS) imaging method was developed to rapid and in situ detect the spatial distribution of lysophospholipids (LPLs) in zebrafish. The combination of MALDI with ultrahigh-resolution FTICR-MS achieves the MS imaging of LPLs with a mass resolution up to 50 000, which allows accurate identification and clear spatial visualization of LPLs in complex biological tissues. A series of lysophosphatidylcholines (LPCs) was detected using positive ion detection mode, and their concentration differences and spatial distributions were clearly visualized in different parts of zebrafish tissue.

One Step Synthesis of Tetragonal-CuBiO/Amorphous-BiFeO Heterojunction with Improved Charge Separation and Enhanced Photocatalytic Properties.

Tetragonal CuBiO/amorphous BiFeO (T-CBO/A-BFO) composites are prepared via a one-step solvothermal method at mild conditions. The T-CBO/A-BFO composites show expanded visible light absorption, suppressed charge recombination, and consequently improved photocatalytic activity than T-CBO or A-BFO alone. The T-CBO/A-BFO with an optimal T-CBO to A-BFO ratio of 1:1 demonstrates the lowest photoluminescence signal and highest photocatalytic activity.

Enzyme-Adsorbed Chitosan Nanogel Particles as Edible Pickering Interfacial Biocatalysts and Lipase-Responsive Phase Inversion of Emulsions.

Here, a simple food-grade Pickering emulsion system is prepared and adopted for biphasic biocatalytic reactions. The chitosan nanogels were prepared with strong dispersion of chitosan aggregates approaching neutral pH and then used as the particle emulsifiers to produce oil-in-water Pickering emulsions. The chitosan nanogel exhibited high affinity to negatively charged lipase.

Covalent Organic Frameworks-Based Solid-Phase Microextraction Probe for Rapid and Ultrasensitive Analysis of Trace Per- and Polyfluoroalkyl Substances Using Mass Spectrometry.

Rapid and ultrasensitive analysis of trace pollutants in complex matrices is of significance for understanding their environmental behaviors and toxic effects. Here a novel method based on the integration of solid-phase microextraction (SPME) and nanoelectrospray ionization mass spectrometry (nanoESI-MS) was developed for rapid and ultrasensitive analysis of trace per- and polyfluoroalkyl substances (PFASs) in environmental and biological samples. A novel SPME probe with F-functionalized covalent organic frameworks (COFs) coating was designed for highly selective enrichment of trace PFASs from complex samples.

Structure, antioxidant and immunomodulatory activity of a polysaccharide extracted from Sacha inchi seeds.

In this study, a novel water-soluble polysaccharide (PVLP-1) was extracted and purified from Sacha inchi (Plukenetia volubilis L.) seeds and the structure, antioxidant and immunomodulatory activity of PVLP-1 were investigated. PVLP-1 (144 kDa) consisted of glucose (69.

A rapid analytical method for the quantitative determination of the sugar in acarbose fermentation by infrared spectroscopy and chemometrics.

In this article, a rapid analytical method for the quantitative determination of the glucose and maltose in the industrial acarbose fermentation was established by the combination application of infrared spectroscopy and chemometrics. The spectra of the 398 acarbose samples were collected by a portable infrared fast analyzer and the concentration of the glucose and maltose in the acarbose fermentation solution were determinate by high performance liquid chromatography (HPLC) as the referent database. Four spectral pretreatment methods, first derivative (FD), second derivative (SD), Savitzky-Golay (SG) convolution smoothing and mean center (MC) were employed to eliminate the optical interference from background and other noise information.

The fabrication of paper separation channel based SERS substrate and its recyclable separation and detection of pesticides.

In this article, a modified paper separation channel SERS substrate was fabricated by a pen writing method for the simultaneous separation and detection of thiuram and dimethoate. The hydrophilic channel was fabricated with both sides of hydrophobic barrier by the Alkylketene dimer (AKD) modified paper substrate, of which the flow dynamic was well conformed to the Lucas-Washburn model and could be used to separate pesticides effectively. As modified by Ag nanoparticles (AgNPs) and ZnO nanoparticles (ZnONPs), the hydrophilic channel exhibited high recyclable SERS detection activity and stability.

Analysis of trace malachite green, crystal violet, and their metabolites in zebrafish by surface-coated probe nanoelectrospray ionization mass spectrometry.

Malachite green (MG) and crystal violet (CV) are the typical triphenylmethane dyes, which are recalcitrant molecules exerting mutagenic and carcinogenic effects on living organisms. Characterization of the residues of MG, CV, and their metabolites in biological organisms is of importance, especially for in vivo and in situ characterization. In this study, a method for determination of trace MG, CV, and their leuco metabolites in zebrafish by surface-coated probe nanoelectrospray ionization mass spectrometry (SCP-nanoESI-MS) was developed.

A heterogeneous pore decoration strategy on a hydrophobic microporous polymer for high-coverage capture of metabolites.

Herein, a heterogeneous pore decoration strategy on a hydrophobic microporous polymer is presented. The smaller pores in the material were completely decorated with hydrophilic polydopamine while most of the larger ones survived after modification, leading to its hydrophobic-hydrophilic hybrid properties and high-coverage capture ability of metabolites.

Recent advances of ambient mass spectrometry imaging for biological tissues: A review.

Ambient mass spectrometry imaging (AMSI) is a molecular imaging technique developed in recent years for in situ and real time visualization of the distribution of chemical compounds in biological tissues without the need of labeling or staining. With the development for more than one decade, AMSI becomes a powerful molecular imaging technique in variousfields such as forensics, metabolomics, cancer diagnosis, and drug monitoring. In this review, we describe the recent advances of AMSI for imaging biological tissues in details.

Nanobodies Based on a Sandwich Immunoassay for the Detection of Staphylococcal Enterotoxin B Free from Interference by Protein A.

As one of the leading causes of food poisoning, staphylococcal enterotoxins (SEs) secreted by pose a serious threat to human health. The immunoassay has become the dominant tool used for the rapid detection of harmful bacteria and toxins as a result of its excellent specificity. However, with regard to SEs, staphylococcal protein A (SpA) is likely to bind with the fragment crystallizable (Fc) terminal of the traditional antibody and result in a false positive, limiting the practical application of this method.

Carbon dots based solid phase microextraction of 2-nitroaniline followed by fluorescence sensing for selective early screening and sensitive gas chromatography-mass spectrometry determination.

For decades, researches have been involving in improving and optimizing solid-phase microextraction (SPME) technique to fit the growing environmental analysis demand. But it is more significant now to introduce meaningful information into the analysis line instead of improving every step in SPME. Herein, we design a carbon dots (CDs) based SPME platform and report its unique application in selective early screening and sensitive detection of 2-nitroaniline.

Improvement of water quality in the Pearl River Estuary, China: a long-term (2008-2017) case study of temporal-spatial variation, source identification and ecological risk of heavy metals in surface water of Guangzhou.

A series of environmental protective policies have been taken recently in the Pearl River Estuary (PRE) to alleviate water pollution; however, their influence on the reduction of heavy metals in estuarine water has not been known. This study selected Guangzhou as a representative city in the PRE and collected estuarine water monthly from 2008 to 2017 to track the variation of As, Hg, Pb, Cd, Cu, Zn, and Se. During the last decade, the high time-resolved record showed that the concentration of Hg, Pb, Cd, Cu, and Zn in estuarine water reduced by 39.

Exploration of a novel triazine-based covalent organic framework for solid-phase extraction of antibiotics.

Covalent organic frameworks (COFs) are a new class of porous materials with a large surface area and potential superiority in sample pretreatment. Herein a novel triazine-based COF named SCAU-1 was fabricated a hydrothermal method, and SNW-1 was also prepared as a contrastive COF material. After characterization, SCAU-1 was used as solid-phase extraction (SPE) adsorbent to concentrate five sulfanilamides (SAs) and four tetracyclines (TCs).

Rapid analysis of short- and medium-chain chlorinated paraffins in wine by dispersive liquid-liquid micro-extraction coupled with high performance liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry.

This study established a simple and rapid method for determination of short-chain chlorinated paraffins (SCCPs) and medium-chain chlorinated paraffins (MCCPs) by dispersive liquid-liquid micro-extraction coupled with high performance liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry (HPLC-ESI-Q-TOF/MS) in white and red wines. Affecting variables, including extraction solvent, salt concentration, ultrasound-vortex conditions and ethanol content, were evaluated. Under optimized conditions, the limit of detection (LODs) for SCCPs and MCCPs were in the range of 0.

Facile Synthesis and Reuse of Magnetic Black Carbon Magnetite (BC-Mag) for Fast Carbamazepine Removal from Water.

Magnetic carbonaceous nanomaterials are needed in water treatment applications because they can offer both carbon surfaces for sorption of organic pollutants and ease of material magnetic retrieval for regeneration and reuse. In this study, we employed a facile one-step method to synthesize a black carbon-magnetite composite (BC-Mag) by high-temperature annealing of black carbon and hematite. The nanocomposite was easily dispersed and stable in water owing to the presence of negatively charged oxygen surface functional groups.

Polydopamine modified ordered mesoporous carbon for synergistic enhancement of enrichment efficiency and mass transfer towards phenols.

Integrating the steps of direct carbonization, removal of silica and polymerization of dopamine, four ordered mesoporous carbons (OMCs) doping with different constituents were prepared and characterized successfully, which were proved to possess similar ordered mesopore structure, high surface area and different hydrophilic properties. Subsequently, a series of pollutants were selected as target analytes to investigate the enrichment capacities of as-prepared OMCs based on the technique of solid phase microextraction (SPME). It was found that the OMC modified with polydopamine (OMC@PDA) demonstrated outstanding performance towards phenols, since its hydrophilicity was enhanced by PDA.

[Distribution, Sources, and Health Risk Assessment of PAHs in Water Supply Source Regions of Guangzhou].

Trace polycyclic aromatic hydrocarbons (PAHs) in drinking water sources have significant harmful effects on human health. Water and sediment samples from water source regions of three water treatment plants in Guangzhou were collected and the distributions of 16 kinds of PAHs were analyzed. The human risk of PAHs in the water samples was also evaluated using the Risk Assessment Guidance for Superfund (RAGS) of the United States Environmental Protection Agency (USEPA).