Versatile poly (deep eutectic solvents) electroactive chitosan eutectogel for infected wound healing and monitoring administration.

The treatment and monitoring of infected skin wounds present significant clinical challenges. Herein, a multifunctional poly(deep eutectic solvent) (PDES) electroactive hydrogel is developed by optimizing the components and the ratio of hydrogen donors and acceptors, achieving well wound hemostasis, wound healing, and monitoring administration performace. The PDES hydrogel dressing exhibits mechanical properties, including high toughness, fatigue resistance (over 9000 compression cycles), and superior skin adhesion (over 70 kPa).

The effect of low donor-to-recipient body weight ratio on graft survival after dual kidney transplantation from pediatric deceased donors.

Background: Dual kidney transplantation (DKT) from small pediatric donors, either en-bloc or split dual kidney transplantation, contributes to mitigating organ scarcity. This study investigates the prognosis of DKT from pediatric deceased donors, and influencing factors.

Method: A retrospective study included recipients who underwent DKT from pediatric donors between 2012 and 2022.

Longitudinal Changes of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer in Highly Myopic Glaucoma: A 3-year Cohort Study.

Purpose: To describe the longitudinal changes in peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (mGC-IPL) thicknesses in highly myopic eyes with and without glaucoma, and to investigate the effects of high myopia (HM) on the sectoral patterns of pRNFL and mGC-IPL thinning.

Design: Longitudinal cohort study.

Participants: A total of 243 eyes from 243 individuals with 3-year follow-up were included in this study: 109 eyes in the HM group, 64 eyes in the open-angle glaucoma (OAG) group and 70 eyes in the highly myopic glaucoma (HMG) group.

Glutathione-scavenging natural-derived ferroptotic nano-amplifiers strengthen tumor therapy through aggravating iron overload and lipid peroxidation.

Nanomedicine-driven ferroptosis has emerged as a promising tumor treatment strategy through delivering exogenous iron and aggravating the lethal accumulation of lipid peroxides (LPO). However, the compensatory mechanisms of ferroptosis defense systems in cancer cells compromise the therapeutic efficacy and lead to potential side effects. Herein, a highly effective ferroptotic nano-amplifier is designed to synergistically promote ferroptosis via increasing intracellular labile iron, exacerbating lipid peroxidation and overcoming the defense system.

Characterizing childhood trauma in individuals based on patterns of intrinsic brain connectivity.

Childhood maltreatment represents a strong psychological stressor that may lead to the development of later psychopathology as well as a heightened risk of health and social problems. Despite a surge of interest in examining behavioral, neurocognitive, and brain connectivity profiles sculpted by such early adversity over the past decades, little is known about the neurobiological substrates underpinning childhood maltreatment. Here, we aim to detect the effects of childhood maltreatment on whole-brain resting-state functional connectivity (RSFC) in a cohort of healthy adults and to explore whether such RSFC profiles can be used to predict the severity of childhood trauma in subjects based on a data-driven connectome-based predictive modeling (CPM).

The relationship between behavioral inhibition and resting electroencephalography: A neuroelectrophysiological study.

Investigating the neurophysiological indicators of behavioral inhibition is crucial; however, despite numerous studies on the relationship between behavioral inhibition and resting-state electroencephalography (rs-EEG), the findings have yielded inconsistent results. Furthermore, these investigations primarily focused on reactive inhibition while neglecting intentional inhibition. Therefore, this study aimed to reassess the correlation between reactive inhibition and rs-EEG metrics while also exploring the association between intentional inhibition and rs-EEG.

Impact of pretreatment strategies and cleaning methods on the cleaning efficacy of electrosurgical instruments: a multicentre study.

Objectives: To investigate the impact of different pretreatment strategies and cleaning methods on the cleaning efficacy of electrosurgical instruments, aiming to propose an optimal protocol.

Methods: A total of 573 electrosurgical instruments were collected from three large-scale hospitals within two hours post-use from December 2023 to July 2024. The instruments were categorized into six group: medical alkaline or multi-enzyme cleaner, or instant foam-type multi-enzyme humectant, followed by either manual cleaning or vacuum boiling washer.

Benzene-induced hematotoxicity enhances the self-renewal ability of HSPCs in Mll-Af9 mice.

Patients with benzene-induced leukemia undergo a continuous transformation from myelosuppression to malignant proliferation. However, the underlying mechanisms in this process remain unknown. Our previous studies have shown that the pathways involved in self-renewal capacity of bone marrow (BM) cells in Mll-Af9 mice exposed to benzene for life are significantly activated after severe blood toxicity.

Roles of cerebrospinal fluid metabolites in mediating the relationship between cathepsins and narcolepsy type 1: A comprehensive Mendelian randomization analysis.

Introduction: To investigate the potential causal relationship between cathepsins and Narcolepsy Type 1 (NT1), along with the mediating influence of cerebrospinal fluid metabolites.

Method: We performed a comprehensive Mendelian randomization (MR) analysis using genome-wide association studies (GWAS) data. Data on nine plasma cathepsins and 338 cerebrospinal fluid metabolites were sourced from the IEU OpenGWAS database, and NT1 were obtained from the FinnGen consortium's R10 release.

Production, structure, and performance of guar gum based bacterial cellulose generated from soy sauce residue hydrolysate by in-situ fermentation.

Guar gum based bacterial cellulose (GG-BC) was generated from the soy sauce residue hydrolysate by in-situ fermentation, and its structure and performance were learned systematically. The GG concentration of 0.2 % was most suitable for GG-BC production with the yield of 1.

Carboxymethyl polysaccharides from Poria cocos (Schw.) wolf: Structure, immunomodulatory, anti-inflammatory, tumor cell proliferation inhibition and antioxidant activity.

This study comprehensively explores the relationship between the structure of carboxymethyl-pachymaran (CMP) and its diverse biological activities, including immunomodulation, anti-inflammatory effects, tumor cell proliferation inhibition, and antioxidant activity. By adjusting preparation parameters, highly purified CMP samples with varying degrees of substitution (DS) and molecular weights (Mw) were successfully obtained. The results indicate that CMP, composed primarily of β-D-glucan, exhibits different levels of activity depending on its structural characteristics.

A water-soluble polysaccharide from finger citron ameliorates diabetes mellitus via gut microbiota-GLP-1 pathway in high-fat diet and streptozotocin-induced diabetic mice.

FCP-2-1, a water-soluble polysaccharide isolated and purified from Finger Citron, demonstrated hypoglycemic effect in vitro in our previous study. However, its antidiabetic effect and underlying mechanism in vivo remain to be elucidated. In this study, the antidiabetic effect of FCP-2-1 and its effects on the gut microbiota, short-chain fatty acids (SCFAs), and glucagon-like peptide-1 (GLP-1) in high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic mice were investigated.

Characterization of extracellular vesicles released from MED4 at the steady state and under a light-dark cycle.

Bacterial extracellular vesicles (EVs) are vesicles secreted by bacteria into the extracellular environment. Containing DNA, RNA and proteins, EVs are implicated to mediate intercellular communications. The marine cyanobacterium , the most abundant photosynthetic organism in marine ecosystems, has been shown to generate EVs continuously during cell growth.

Icariin Facilitates Osteogenic Differentiation and Suppresses Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Enhancing SOST Methylation in Postmenopausal Osteoporosis.

Purpose: Postmenopausal osteoporosis (PMO) is mainly concerned with the imbalance of bone resorption and bone formation. Icariin (ICA) plays a vital role in bone protection. This study investigated the mechanism of ICA in PMO rats.

Insights into Q-marker of Shensong Yangxin capsule in treating cardiac arrhythmias based on a linear substitution strategy in quantification of multiple components.

Background: The concept of a Quality marker (Q-marker) has emerged as a crucial tool for ensuring the safety and efficacy of Traditional Chinese Medicine (TCM) formulas. However, significant challenges remained in the identification and practical application of Q-marker, particularly due to the scarcity of reference standards.

Purpose: This study aimed to achieve a multidimensional integration of chemical profiling, target tissue distribution and in vivo high-throughput screening model to effectively identify the Q-marker of Shensong Yangxin Capsule (SSYX) and propose a linear substitution strategy for the quantification of multiple components.

A data-driven framework to identify influencing factors for soil heavy metal contaminations using random forest and bivariate local Moran's I: A case study.

The efficacy of traceability analysis is often limited by a lack of information on influencing factors for heavy metal (HM) contaminations in soil, such as spatial correlations between HM concentrations and influencing factors. To overcome this limitation, a novel data-driven framework was established to identify influencing factors for soil HM concentrations in an industrialised study area, in Guangdong Province, China, mainly using random forest (RF) and bivariate local Moran's I (BLMI) on the basis of the 577 soil samples and the 18 environmental covariates. The quantitative contributions of the 18 influencing factors for the Cd, As, Pb, and Cr concentrations were determined by the optimised RF.

Contrastive independent subspace analysis network for multi-view spatial information extraction.

Multi-view classification integrates features from different views to optimize classification performance. Most of the existing works typically utilize semantic information to achieve view fusion but neglect the spatial information of data itself, which accommodates data representation with correlation information and is proven to be an essential aspect. Thus robust independent subspace analysis network, optimized by sparse and soft orthogonal optimization, is first proposed to extract the latent spatial information of multi-view data with subspace bases.

Epidemiology and genotypic diversity of duck hepatitis B virus identified from waterfowl in partial areas of Guangdong province, Southern China.

Duck Hepatitis B virus (DHBV) infection model is extensively utilized as an animal model for studying human hepatitis B virus infection and for comparative research. 557 liver samples from geese and ducks were collected in parts of Guangdong province, southern China. The overall prevalence of DHBV was 45.

Chemogenetic modulation of parathyroid hormone secretion alleviates osteoporosis in ovariectomized rats.

Parathyroid hormone (PTH) is critical for regulating calcium and phosphate homeostasis, and its dysregulation contributes to osteoporosis. Current methods for precise control of PTH secretion are limited. This study explores chemogenetic tools to regulate PTH secretion in parathyroid chief cells via Gq/Gi signaling.

When multiple instance learning meets foundation models: Advancing histological whole slide image analysis.

Deep multiple instance learning (MIL) pipelines are the mainstream weakly supervised learning methodologies for whole slide image (WSI) classification. However, it remains unclear how these widely used approaches compare to each other, given the recent proliferation of foundation models (FMs) for patch-level embedding and the diversity of slide-level aggregations. This paper implemented and systematically compared six FMs and six recent MIL methods by organizing different feature extractions and aggregations across seven clinically relevant end-to-end prediction tasks using WSIs from 4044 patients with four different cancer types.

Social support, fear of cancer recurrence and sleep quality in breast cancer: A moderated network analysis.

Purpose: Fear of cancer recurrence (FCR) contributes to sleep problems and social support is a buffering factor in the literature. However, the moderating effect of social support between FCR and sleep quality is unclear.

Methods: The moderating role of social support was examined in a cohort of 460 breast cancer patients from the 2024 Be Resilient to Breast Cancer (BRBC) program from a microscopic perspective using moderated network analysis, and then assessed macroscopically by Johnson-Neyman and response surface analysis.

A novel method of species-specific molecular target mining and accurate discrimination of Bacillus cereus sensu lato.

Bacillus cereus, a member of the Bacillus cereus sensu lato (B. cereus s.l.

Genome-wide identification, evolution and expression of pax gene family members in mandarin fish (Siniperca chuatsi).

The pax gene family is involved in the development process through its extensive effects on cell proliferation, differentiation, and apoptosis. Herein, the whole pax gene family members of mandarin fish (Siniperca chuatsi) were first identified and characterized. By comparing pax gene family members from another 13 representative animals, an expansion of pax gene family members was observed in teleosts.

Green development strategy for efficient quercetin- loaded whey protein complex: Focus on quercetin loading characteristics, component interactions, stability, antioxidant, and in vitro digestive properties.

This study aimed to develop a quercetin-loaded whey protein complex using pH-induced co-assembly for the intestinal-targeted delivery of quercetin. The investigation focused on quercetin loading capacity, formation mechanism, stability, antioxidant activity, and in vitro digestive properties of the complex. The results indicated that the stable complex was obtained at a quercetin-to-protein mass ratio of 1:20, exhibiting a high encapsulation efficiency (96.

Fabrication and characterization of fish oil emulsions stabilized by metal-phenolic network coatings-decorated Acipenser sturgeon protein.

Acipenser sturio fish oil, rich in ω-3 PUFAs, offers potential for functional foods but is prone to oxidative degradation. This study investigates enhancing antioxidant and emulsifying properties of the oil by modifying Acipenser sturgeon protein (ASP) using metal-phenolic networks (MPNs). ASP was coated with EGCG (epigallocatechin-3-gallate) and Ca, forming ASP-EGCG-Ca complexes (AECas) used as emulsifiers.