A study on the association of rs7950273 polymorphism in the PDGFD with ischaemic stroke in the Chinese Han population.

Background: The association between the platelet-derived growth factor D (PDGFD) gene and atherosclerosis has been widely proven, whereas the relationship between the PDGFD gene and ischaemic stroke remains unconfirmed.

Aim: A case-control study was performed to further evaluate the association of the C → G mutation of rs7950273 in the PDGFD gene with ischaemic stroke (IS) in a Chinese Han population.

Subjects And Methods: This study recruited 3033 cases and 2807 controls from general hospitals in the southern, central and northern areas of China.

Quercetin prevents cardiac hypertrophy induced by pressure overload in rats.

Inhibition of cardiac hypertrophy leads to a significant reduction in cardiovascular mortality and morbidity. Quercetin is by far the most abundant flavonoid and believed to ameliorate cardiovascular disease. Therefore, we investigated whether quercetin supplementation could attenuate the development of cardiac hypertrophy induced by pressure overload.