Clinical implication of NT-proBNP to predict mortality in patients with acute type A aortic dissection: a retrospective cohort study.

Objectives: Acute type A aortic dissection is a life-threatening cardiovascular disease commonly seen in emergency department, resulting in substantial mortality and morbidity. We aimed to investigate the prognostic value of N-terminal pro-B type natriuretic peptide (NT-proBNP) among this critically ill population.

Design: The design of this study was a retrospective cohort study.

Effect of virtual reality intervention on hospitalized patients with acute pain after thoracoscopic surgery: a pilot randomized clinical trial.

The study investigates the effectiveness of immersive virtual reality (VR) as a nonpharmaceutical approach to manage postoperative pain in patients following thoracoscopic surgery. In this single-center, triple-arm pilot randomized controlled trial (RCT), 61 postsurgical patients with a postoperative pain numerical rating scale (NRS) score ≥4 after receiving standard analgesia were included and assigned to either a quantum clinics-VR (QTC-VR) group, a Placebo-VR group, or a control group. The QTC-VR group engaged in a daily 10-minute interactive pain relief 3D-VR program, while the Placebo-VR group watched a daily 10-minute relaxation-based 2D film through VR headsets for three days following surgery.

Comparative efficacy of different drugs in acute heart failure with renal dysfunction: a systematic review and network meta-analysis.

Objective: This network meta-analysis was to compare the efficacy of different drugs on cardiac function, renal function, and clinical outcomes in patients with acute heart failure (AHF) accompanied by renal dysfunction.

Methods: PubMed, EMBASE, Cochrane Library, and Web of Science were searched to screen all clinical trials of AHF between January 1st 2001 and March 31th 2024. The primary outcome measures were N-terminal pro-B type natriuretic peptide (NT-proBNP), B-type natriuretic peptide (BNP), glomerular filtration rate (GFR), blood urea nitrogen, serum creatinine, all-cause mortality within 60 days, and cardiovascular mortality.

Sensitivity improvement of fiber optic interferometric hydrophone based on composite structure.

This paper proposes a high-performance fiber optic interferometric hydrophone based on composite structure. Based on the air-backed push-pull fiber optic hydrophone structure, the inner elastic tube is replaced by a thick hollow column, introducing axial acoustic pressure sensing to improve the detection sensitivity of the fiber optic hydrophone. The influence of axial stress on the deformation of the composite structure is investigated by theoretical analysis and numerical simulation, and the structural design of fiber optic hydrophone with high acoustic pressure sensitivity and wide frequency response range is realized.

Dynamics of chemical profile and microbial community in 3 consecutive years reveal Rhodococcus and Apiotrichum are potential microbes contributing to quality formation of Guang Chenpi.

Currently, there remains a debate regarding the functional microorganisms responsible for the quality formation of Guang Chenpi (GCP). Thus, the metabolite profiles and microbial diversity of GCP samples subjected to natural treatment versus those sterilized via electron beam irradiation were investigated over a three-year period. It was found the main constituents of GCP were influenced both by spontaneous changes and microbial activity.

Topological Supramolecular Complexation of Metal-Organic Polyhedra for Tunable Interconnected Hierarchical Microporosity in Amorphous Form.

The precise engineering of microporosity is challenging due to the interference at sub-nm scale from unexpected structural flexibility and molecular packing. Herein, the concept of topological supramolecular complexation is proposed for the feasible fabrication of hierarchical microporosity with broad tunability in amorphous form. The 2.

A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement.

In human aging, liver aging per se not only increases susceptibility to liver diseases but also increases vulnerability of other organs given its central role in regulating metabolism. Total liver function tends to be well maintained in the healthy elderly, so liver aging is generally difficult to identify early. In response to this critical challenge, the Aging Biomarker Consortium of China has formulated an expert consensus on biomarkers of liver aging by synthesizing the latest scientific literature, comprising insights from both scientists and clinicians.

Telomeres, telomerase, and cancer: mechanisms, biomarkers, and therapeutics.

Telomeres and telomerase play crucial roles in the initiation and progression of cancer. As biomarkers, they aid in distinguishing benign from malignant tissues. Despite the promising therapeutic potential of targeting telomeres and telomerase for therapy, translating this concept from the laboratory to the clinic remains challenging.

Isolation and identification of pigeon adenovirus 1 and analysis of its pathogenicity in pigeons and chickens.

Pigeon adenovirus type 1 predominantly infects pigeons under 12 months of age (mainly 3-5 months old), causing major clinical symptoms such as vomiting, dehydration, and discharge of thin yellow feces. In February 2023, an outbreak of a pathogen with symptoms similar to pigeon adenovirus infections occurred on a pigeon farm in Shandong Province, which was eventually identified as pigeon adenovirus type 1. In this study, a strain of PiAdV-1 was isolated from naturally infected pigeons and named pigeon-adenovirus-1-isolate-CH-SD-2023, and the hexon gene sequence as amplified and analyzed using polymerase chain reaction (PCR).

Genetically and chemically intraspecific variations of Ficus hirta provide novel insights into its protection and utilization.

Background: Radix Fici Hirtae, the dry root of Ficus hirta, is a famous ethnomedicine and food that has been widely used by Yao and Zhuang nationalities in southern China for its potent antitumor, antifungal, and hepatoprotective effects. Recently, owing to over-exploitation and habitat destruction, F. hirta has been pushed to the brink of depletion.

Hirsutine Mitigates Ferroptosis in Podocytes of Diabetic Kidney Disease by Downregulating the p53/GPX4 Signaling Pathway.

Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease worldwide, and podocyte ferroptosis plays a crucial role in its pathogenesis. Hirsutine (HS) reduces blood glucose levels and improve insulin resistance in diabetic mice, suggesting its potential use in diabetes treatment. Here, we established a db/db mouse model of DKD and administered HS for 8 weeks.

Assessing the Causal Relationships Between Lipid Species and Stroke by Using Mendelian Randomization.

Circulating lipids and changes in lipid profiles have long been associated with the development of stroke but causal relationships remain unclear.In this study, we aimed to assess the causal relationships between lipid species and multiple stroke phenotypes to inform stroke prevention and treatment strategies. We conducted a two-sample Mendelian randomization analysis using data from genome-wide association studies.

AI-assisted radiologists vs. standard double reading for rib fracture detection on CT images: A real-world clinical study.

To evaluate the diagnostic accuracy of artificial intelligence (AI) assisted radiologists and standard double-reading in real-world clinical settings for rib fractures (RFs) detection on CT images. This study included 243 consecutive chest trauma patients (mean age, 58.1 years; female, 166) with rib CT scans.

Decoding Plant-Pathogen Interactions: A Comprehensive Exploration of Effector-Plant Transcription Factor Dynamics.

In the coevolutionary process between plant pathogens and hosts, pathogen effectors, primarily proteinaceous, engage in interactions with host proteins, such as plant transcription factors (TFs), during the infection process. This review delves into the intricate interplay between TFs and effectors, a key aspect in the prolonged and complex battle between plants and pathogens. Effectors strategically manipulate TFs using diverse tactics.

Clinical features of inflammatory arthritis in daily practice-China's perspective.

Objective: This study aimed to analyze and compare the proportion of patients with different types of inflammatory arthritis and investigate the clinical characteristics, including symptoms and signs, medication choices, and disease activity, in the daily clinical practice of China.

Methods: Patients with inflammatory arthritis were recruited from 16 Grade-A tertiary hospitals between August 2021 and April 2022. The medical profiles, encompassing sociodemographic characteristics, clinical and laboratory date, were collected.

Random Frequency Division Multiplexing.

In this paper, we propose a random frequency division multiplexing (RFDM) method for multicarrier modulation in mobile time-varying channels. Inspired by compressed sensing (CS) technology which use a sensing matrix (with far fewer rows than columns) to sample and compress the original sparse signal simultaneously, while there are many reconstruction algorithms that can recover the original high-dimensional signal from a small number of measurements at the receiver. The approach choose the classic sensing matrix of CS-Gaussian random matrix to compress the signal.

Comparative study on organoleptic properties and volatile organic compounds in turmeric, turmeric essential oil, and by-products using E-nose, HS-GC-IMS, and HS-GC-MS.

The properties, applications, and in vitro bioactivities of turmeric, turmeric essential oil (TEO), and turmeric essential oil by-products (TEO-BP) were evaluated using sensory analysis, gas chromatography-mass spectrometry (GC-MS), gas chromatography-ion mobility spectrometry (GC-IMS), and electronic nose techniques. A total of 62 and 66 volatile organic compounds (VOCs), primarily terpenoids and sesquiterpenoids, were identified by GC-MS and GC-IMS, respectively. Distillation temperature, particularly at 90 °C, significantly influenced the color and organoleptic properties of TEO, with variations in VOC profiles driving these differences.

The unique association between estimated pulse wave velocity and the prevalence of diabetic kidney disease: a cross-sectional study.

Objective: Arteriosclerosis plays a significant role as one of the key pathological mechanisms underlying Diabetic Kidney Disease (DKD). The estimated Pulse Wave Velocity (ePWV) is used to assess arteriosclerosis, and is considered a potential clinical surrogate for pulse wave velocity. There are no studies on ePWV in relation to DKD.

Characteristics of salt dust aerosols and their transport implications in the Aral Sea.

Central Asia is an ecologically fragile arid zone and a typical mixed salt‒sand region. The socioeconomic and ecological problems attributed to the shrinking of the Aral Sea in Central Asia are notable concerns within the international community. In this study, the characteristics of salt dust aerosols from the Aral Sea were analysed to explore their interannual variation characteristics and analyse the spatial and temporal distributions of salt dust sources and transport and dispersion pathways.

Post-traumatic growth experience of breast cancer patients: A qualitative systematic review and meta-synthesis.

Objectives: This study aimed to systematically incorporate the post-traumatic growth experience of breast cancer patients and furnish insights for the formulation of targeted psychological care measures.

Methods: The search period we were ranged from establishing the database to February 2024. We systematically searched four Chinese databases and seven English databases.

Systemic inflammation response index association with gout in hyperuricemic adults: NHANES 2007-2018.

Background: Hyperuricemia is the underlying condition of gout. Previous studies have indicated that specific strategies may be effective in preventing the progression of hyperuricemia to gout. However, there is a lack of widely applicable methods for identifying high-risk populations for gout.

Molybdenum and Sulfur Doping To Create Active Sites and Regulate d-Band Centers of Ni-Mo-S Electrocatalysts for the Hydrogen Evolution Reaction.

Defining the active sites and further optimizing their activity are of great significance for enhancing the hydrogen evolution reaction (HER) performances, especially for inexpensive Ni-based catalysts doped with metals and nonmetal elements. This work reports the role of the incorporated molybdenum and sulfur in enhancing the HER activity of nickel. The prepared molybdenum and sulfur coincorporated Ni (NMS) electrocatalysts exhibit excellent HER performance, with an overpotential and Tafel slope of 77.