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Paternal exposure to methotrexate and pregnancy outcomes.

J Rheumatol

April 2011

Centre de Référence sur les Agents Tératogènes (CRAT), Hôpital Armand Trousseau, Groupe Universitaire Est, Paris, France.

Objective: To assess the risk of major malformation in the case of paternal exposure to methotrexate (MTX) at the time of conception.

Methods: Using prospective data of our Teratology Information Service, we analyzed outcomes of paternal MTX exposure at the time of conception or up to 3 months before conception.

Results: We report on the outcomes of 42 pregnancies involving 40 men treated with MTX at the time of conception.

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