474 results match your criteria: "Groupe hospitalier Diaconesses Croix-Saint-Simon[Affiliation]"

Serious complications and recurrences after retropubic vs transobturator midurethral sling procedures for 2682 patients in the VIGI-MESH register.

Am J Obstet Gynecol

April 2024

Faculté de Médecine et Pharmacie, Université de Poitiers, Inserm CIC 1402, Service de Gynécologie-Obstétrique et Médecine de la Reproduction, CHU de Poitiers, Poitiers, France.

Background: Midurethral slings are the gold standard for treating stress urinary incontinence, but their complications may raise concerns. Complications may differ by the approach used to place them.

Objective: This study aimed to compare serious complications and reoperations for recurrence after midurethral sling procedures when using the retropubic vs the transobturator route for female stress urinary incontinence.

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Article Synopsis
  • Septic bursitis (SB) is a prevalent inflammatory condition, particularly linked to certain professions, and currently lacks standardized management guidelines.
  • A collaborative group of healthcare specialists developed specific recommendations for treating olecranon and prepatellar SB, using a combination of literature review and expert insights.
  • The newly established guidelines, aimed at various healthcare providers, emphasize the role of biological tests, imaging, antibiotic treatments, and address surgical options and prevention strategies.
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Background: Periprosthetic joint infection is a severe complication of joint replacement surgery. Thus two-stage exchange remains the gold standard, one-stage exchange is now widely recommended. We hypothesized that, for patients with chronic periprosthetic shoulder infection (PSI), treatment with a one-stage exchange would be an effective approach to eradicate infection, relieve pain, and restore function to the involved shoulder.

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Objectives: Heart involvement is one of the leading causes of death in systemic sclerosis (SSc). The prevalence of SSc-related cardiac involvement is poorly known. Our objective was to investigate the prevalence and prognosis burden of different heart diseases in a nationwide cohort of patients with SSc.

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Article Synopsis
  • The study investigates the optimal daily dose of clindamycin for patients undergoing treatment for bone-and-joint infections when used in combination with rifampicin through continuous infusion.
  • A population pharmacokinetic model was developed, and Monte Carlo simulations were performed to determine effective dosing regimens, revealing that a minimum dose of 4200 mg/24h achieves desired plasma concentrations in over 90% of patients.
  • The findings endorse high-dose continuous infusion of clindamycin alongside rifampicin, emphasizing the need for regular monitoring to adjust doses as necessary for patient safety.
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[FRANCOGYN group: A brief history].

Gynecol Obstet Fertil Senol

January 2024

Service de gynécologie, centre hospitalier régional universitaire de Tours, hôpital Bretonneau, université François-Rabelais, unité Inserm 1069, 2, boulevard Tonnelle, 37044 Tours, France.

Objectives: Describing the constitution of the FRANCOGYN group (a national French research group in Oncological and Gynecological Surgery) and present its current and future development.

Methods: Literature review using PUBMed database with the keyword "FRANCOGYN".

Objectives: Describing the constitution of the FRANCOGYN group (a national French research group in Oncological and Gynecological Surgery) and present its current and future development.

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Background: Poly(ADP-ribose) polymerase (PARP) inhibitor maintenance therapy is the standard of care for some patients with advanced ovarian cancer. We evaluated the efficacy and safety of PARP inhibitor rechallenge.

Patients And Methods: This randomized, double-blind, multicenter trial (NCT03106987) enrolled patients with platinum-sensitive relapsed ovarian cancer who had received one prior PARP inhibitor therapy for ≥18 and ≥12 months in the BRCA-mutated and non-BRCA-mutated cohorts, respectively, following first-line chemotherapy or for ≥12 and ≥6 months, respectively, following a second or subsequent line of chemotherapy.

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Brachytherapy and surgery versus surgery alone for IB2 (FIGO 2018) cervical cancers: A FRANCOGYN study.

Eur J Obstet Gynecol Reprod Biol

November 2023

CHU Lille, Service de chirurgie gynécologique, F-59000 Lille, France; Univ. Lille, CHU Lille, F-59000 Lille, France. Electronic address:

Objective: Evaluation of the management by first brachytherapy followed by radical hysterectomy (Wertheim type) compared to radical hysterectomy alone (Wertheim type) for the treatment of IB2 cervical cancer.

Methods: Data from women with histologically proven FIGO stage IB2 cervical cancer treated between April 1996 and December 2016 were retrospectively abstracted from twelve French institutions with prospectively maintained databases.

Results: Of the 211 patients with FIGO stage IB2 cervical cancer without lymph node involvement included, 136 had surgical treatment only and 75 had pelvic lymph node staging and brachytherapy followed by surgery.

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Background: Small bowel adenocarcinoma is a rare cancer, and the role of adjuvant chemotherapy for localized disease is still debated.

Methods: This retrospective multicenter study included all consecutive patients who underwent curative surgical resection for localized small bowel adenocarcinoma between 1996 and 2019 from 3 French cohort studies. Prognostic and predictive factors of adjuvant chemotherapy efficacy were analyzed for disease-free survival and overall survival.

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Atezolizumab Combined With Bevacizumab and Platinum-Based Therapy for Platinum-Sensitive Ovarian Cancer: Placebo-Controlled Randomized Phase III ATALANTE/ENGOT-ov29 Trial.

J Clin Oncol

October 2023

Department of Gynecology with Center for Oncological Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Purpose: Platinum-based doublets with concurrent and maintenance bevacizumab are standard therapy for ovarian cancer (OC) relapsing after a platinum-free interval (PFI) >6 months. Immunotherapy may be synergistic with bevacizumab and chemotherapy.

Patients And Methods: ATALANTE/ENGOT-ov29 (ClinicalTrials.

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[Not Available].

Bull Cancer

June 2023

Groupe d'investigateurs nationaux pour les études des cancers de l'ovaire, 8 rue Lamennais, 75008 Paris, France; Département d'oncologie médicale, centre Léon-Bérard, université Claude-Bernard, Lyon 1, 69008 Lyon, France.

Management of high grade, serous and/or endometrioid, advanced (stages III-IV) ovarian carcinomas and HRD-BRCA testing in 2023: update according to data published/presented in 2022 Molecular analysis of ovarian carcinomas must be now systematically performed to determine BRCA1 and BRCA2 status as well as genomic instability score. Several types of tests are available. From a clinical perspective, new data from phase III clinical trials presented in 2022 confirm the key role of PARP inhibitors in first-line medical treatment of high-grade serous ovarian cancers.

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Purpose: Immediate revision refers to a reoperation that involves resetting, draping, and exchanging the implant, after wound closure in total hip arthroplasty. The purpose of this study is to investigate the impact of immediate revision after total hip arthroplasty on subsequent infection and complication rates.

Methods: A total of 14,076 primary total hip arthroplasties performed between 2010 and 2020 were identified in our institutional database, of which 42 underwent immediate revision.

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Article Synopsis
  • The study evaluates the outcomes of delayed coloanal anastomosis (DCAA), focusing on its use as both a primary procedure and as a salvage after failed surgery.
  • Among 564 patients, complications occurred at similar rates for both types of DCAA, but anastomotic leakage was more common in salvage DCAA cases.
  • DCAA successfully preserved bowel continuity for 74% of patients after three years, with 75% of those not initially having a stoma avoiding it entirely by the last follow-up.
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Moderate or intensive management of the active phase of second-stage labor and risk of urinary and anal incontinence: results of the PASST randomized controlled trial.

Am J Obstet Gynecol

November 2023

Université Paris Cité, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Institut national de la santé et de la recherche médicale (Inserm), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), Paris, France; AP-HP, Maternity Port Royal, FHU PREMA, Paris, France.

Background: Incontinence occurs frequently in the postpartum period. Several theoretical pathophysiological models may underlie the hypothesis that different types of management of the active phase of the second stage of labor have different effects on pelvic floor muscles and thus perhaps affect urinary and anal continence.

Objective: This study aimed to evaluate the impact of "moderate pushing" on the occurrence of urinary or anal incontinence compared with "intensive pushing," and to determine the factors associated with incontinence at 6 months postpartum.

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Article Synopsis
  • Group A streptococcus causes 20-40% of childhood sore throats (pharyngitis), often requiring antibiotics only in bacterial cases; most guidelines suggest confirming infection before treatment.
  • This study evaluates the effectiveness of a new saliva test (Abbott ID NOW STREP A2) for detecting group A streptococcus compared to the traditional throat swab test in children with pharyngitis.
  • The research aims to recruit 800 children and will assess various outcomes, including sensitivity, result time, and satisfaction among patients and parents, to see if saliva testing is a viable and convenient alternative to throat swabs.
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Factors associated with COVID-19 severity in patients with spondyloarthritis: Results of the French RMD COVID-19 cohort.

Joint Bone Spine

December 2023

Department of Rheumatology, Aix-Marseille université, AP-HM, CHU de Sainte-Marguerite, 270, boulevard Sainte-Marguerite, 13009 Marseille, France. Electronic address:

Objectives: The objective of the current study was to evaluate the severity of COVID-19 and identify factors associated with severe disease outcomes in patients with spondyloarthritis (SpA), a chronic inflammatory rheumatic and musculoskeletal disease (RMD).

Methods: We utilized patient data from the French national multicenter RMD COVID-19 cohort (NCT04353609). The primary outcome was to describe COVID-19 characteristics in patients with SpA based on disease severity of COVID-19 (mild, moderate or severe) with serious infection including moderate and severe cases.

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Comparing COVID-19 disease severity in patients with rheumatic and inflammatory diseases between the first and the subsequent waves.

Joint Bone Spine

September 2023

Department of Internal Medicine and Clinical immunology, Referral Centre for Rare Systemic Auto-immune Diseases North and North-West of France, Lille University School of Medicine, Lille, France.

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Introduction: Ampullary neuroendocrine neoplasia (NEN) is rare and evidence regarding their management is scarce. This study aimed to describe clinicopathological features, management, and prognosis of ampullary NEN according to their endoscopic or surgical management.

Methods: From a multi-institutional international database, patients treated with either endoscopic papillectomy (EP), transduodenal surgical ampullectomy (TSA), or pancreaticoduodenectomy (PD) for ampullary NEN were included.

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Introduction: Serum prostate specific antigen (PSA) is a well-known prognostic parameter in men with prostate cancer. The treatment of men with very high PSA values and apparently no detectable metastases is not fully established.

Patients And Methods: Ancillary analysis from the GETUG 12 phase 3 trial.

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Olaparib plus bevacizumab first-line maintenance in ovarian cancer: final overall survival results from the PAOLA-1/ENGOT-ov25 trial.

Ann Oncol

August 2023

AGO, Germany; Department of Gynaecology & Gynaecologic Oncology, Ev. Kliniken Essen-Mitte, Essen, Germany.

Background: In the PAOLA-1/ENGOT-ov25 primary analysis, maintenance olaparib plus bevacizumab demonstrated a significant progression-free survival (PFS) benefit in newly diagnosed advanced ovarian cancer patients in clinical response after first-line platinum-based chemotherapy plus bevacizumab, irrespective of surgical status. Prespecified, exploratory analyses by molecular biomarker status showed substantial benefit in patients with a BRCA1/BRCA2 mutation (BRCAm) or homologous recombination deficiency (HRD; BRCAm and/or genomic instability). We report the prespecified final overall survival (OS) analysis, including analyses by HRD status.

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Objective: Identifying prognostic factors and evaluating the impact of adjuvant chemotherapy in patients with sex cord stromal tumors (SCST) is crucial. In this study, we aimed to address these challenges.

Methods: We conducted a retrospective analysis of data from 13 centers of the French Rare malignant gynecological tumors (TMRG) network.

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