[Metabolic disorders in drug addictions].

The metabolic disturbances caused by compulsory drug intake into animals and men were characterized. The probable mechanisms of these disturbances are discussed.

[Regulation of intracellular CoA pool as one of approaches to correction of metabolic disorders].

The problems of biosynthesis of coenzyme A, its transport into the mitochondria, and compartmentalization in mammalian cells have been reviewed. Co A pool structure in liver cells and the in myocardium under different pathobiochemical conditionsis discussed. Experimental data which have now been accumulated can be used as a basis for correction of the metabolic disturbances of different etiology.

[Changes in lipid metabolism with the use of alcohol deterrent preparations].

The available experimental and clinical data in the literature on the effect of antialcoholic drugs (disulfiram, cyanamide, pyrazol) on the lipid composition of tissues (blood serum, liver, brain) are systematized and generalized. Drugs used in the treatment of alcoholism were found to cause essential changes in the metabolism of lipid fractions. This indicates the necessity for recording the detected changes in lipid metabolism in pharmacotherapy of alcoholism.

[Phospholipid composition of different rat brain regions in acute alcoholic intoxication].

The effect of acute ethanol intoxication (25% solution, intragastrically, 4 g/kg, 1 h) on the concentration of phospholipid fractions in different rat brain regions was studied. It was found that acute alcohol intoxication decreased the level of phosphatidylcholine and increased the concentration of phosphatidylethanolamine in the cerebellum of experimental animals. The cortex of large hemispheres showed a decreased amount of phosphatidylcholine and increased one of sphingomyelin.