2,085 results match your criteria: "Grenoble-Alpes University[Affiliation]"

Hereditary angioedema in children: Review and practical perspective for clinical management.

Pediatr Allergy Immunol

December 2024

French National Reference Center for Angioedema (CREAK), Center of Excellence and Reference (ACARE), Internal Medicine Department, Grenoble Alpes University Hospital, Grenoble, France.

Background: Hereditary angioedema (HAE) in children has specific features and requires multidisciplinary management.

Methods: We performed a literature search and underwent in-depth discussions to provide practical tools for physicians.

Results: HAE is a rare, life-threatening genetic disorder.

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Venous thromboembolism (VTE) rarely occurs during childhood and, with few exceptions, should be considered as a disease of sick children. Current recommendations concerning the duration of anticoagulant treatment for paediatric VTE are essentially based on the results of clinical trials conducted in adults. Yet the underlying medical conditions, incidence, and anatomical locations of the disease, as well as the rates of unprovoked VTE, morbidity, and mortality, differ between adults and children.

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Background: Nivolumab obtained approval in advanced melanoma (AM) with weight-adjusted dose (WAD) administration (3 mg/kg/2 weeks). In 2018, the dosage regimen was changed to flat dose (FD) administration (240 mg/2 weeks or 480 mg/4 weeks) based on a modeling study, without clinical data.

Methods: AM patients have been prospectively included in the French national multicenter MelBase database since 2013.

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Why does tinnitus vary with naps? A polysomnographic prospective study exploring the somatosensory hypothesis.

Hear Res

January 2025

Université Paris Cité, VIFASOM ERC 7330, Vigilance Fatigue Sommeil et Santé publique, Paris, France; APHP Hôtel-Dieu, Centre du Sommeil et de la Vigilance, Paris, France.

Background: Tinnitus, defined as the conscious awareness of a noise without any identifiable corresponding external acoustic source, can be modulated by various factors. Among these factors, tinnitus patients commonly report drastic increases of tinnitus loudness following nap sleep. Previous studies have suggested that this clinical pattern could be attributed to a somatosensory modulation of tinnitus.

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Long term noninvasive respiratory support in children with OSA-I and OSA-II: Data of a nation-wide study.

Sleep Med

November 2024

Pediatric Noninvasive Ventilation and Sleep Unit, AP-HP, Hôpital Necker-Enfants Malades, F-75015, Paris, France; Université de Paris Cité, EA 7330 VIFASOM, F-75004, Paris, France. Electronic address:

Purpose: The aim of the study was to analyze the characteristics of otherwise healthy children with obstructive sleep apnea (OSA; OSA-I) and children with OSA and non-syndromic obesity (OSA-II) treated with long term continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) in 2019 in France.

Methods: Data were collected from a national survey on paediatric home noninvasive ventilatory support. CPAP/NIV initiation criteria and duration, age at CPAP/NIV initiation, equipment used and CPAP/NIV settings, and objective compliance were analyzed.

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Article Synopsis
  • The ERAS protocol for colorectal surgery has been evaluated for its impact on long-term survival and recurrence, but results show no significant advantages compared to traditional care.
  • The study analyzed data from 981 patients, finding that 5-year overall survival (OS) and recurrence-free survival (RFS) rates were similar between ERAS and non-ERAS groups.
  • Key risk factors for poor outcomes included age, low BMI, smoking, high ASA score, and laparotomy, with age identified as a protective factor for RFS when adjusted for the ERAS group.
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Introduction: Improving adverse events following immunisation (AEFI) detection is vital for vaccine safety surveillance, as an early safety signal can help minimize risks. In February 2022, the World Health Organization reported a preliminary signal on sudden sensorineural hearing loss (SSNHL) following coronavirus disease 2019 (COVID-19) vaccination, 54 million persons in France received at least one dose, covering 78.8% of the population within a year.

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Article Synopsis
  • * Results indicate that while disposable cystoscopes might reduce waste and water usage, the overall environmental benefits of disposables versus reusables are unclear due to varying reprocessing methods.
  • * The review highlights the need for improved strategies, such as better reprocessing of reusable scopes and conducting environmental audits in the healthcare industry, to decrease the carbon footprint of urological procedures.
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Li-Fraumeni syndrome (LFS) is a heterogeneous predisposition to an individually variable spectrum of cancers caused by pathogenic germline variants. We used a clustering method to assign TP53 missense variants to classes based on their functional activities in experimental assays assessing biological p53 functions. Correlations with LFS phenotypes were analyzed using the public germline mutation database and validated in three LFS clinical cohorts.

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Article Synopsis
  • * Analysis included four studies with 883 patients, revealing that subacromial decompression surgery is not cost-effective compared to physiotherapy, especially for conditions like frozen shoulder.
  • * The conclusion emphasizes prioritizing treatments that minimize productivity loss and urges the need for more high-quality economic studies to better assess treatment management in this area.
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  • Inorganic halide perovskites like Cs₂InSbX₆ (X = F, Cl) are being researched for their potential in solar cells and photocatalysis due to their ability to capture light effectively.
  • The study used Density Functional Theory (DFT) to analyze how mechanical strain impacts the electronic and optical properties of these materials, finding that negative strain improves their performance, especially for Cs₂InSbCl₆, which absorbs well in the visible spectrum.
  • Results suggest Cs₂InSbCl₆, with its adjustable bandgap and enhanced optical properties under strain, could be an eco-friendly alternative to lead-based perovskites in solar energy applications.
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In the development of anticancer medications, vascular endothelial growth factor receptor 2 (VEGFR-2), which belongs to the protein tyrosine kinase family, emerges as one of the most significant targets of interest. The ongoing Food and Drug Administration (FDA) approval of novel therapeutic medicines toward VEGFR-2 emphasizes the urgent need to discover sophisticated molecular structures that are capable of reliably limiting VEGFR-2 activity. Recognizing the huge potential of deep-learning-based molecular model advancements, we focused our study on exploring the chemical space to find small molecules potentially inhibiting VEGFR-2.

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An increase in paediatric arthroscopy in Europe: Experience of the EPOS Sport Study Group.

J Child Orthop

November 2024

Pediatric Orthopedic Department, Hôpital des Enfants de Toulouse, Toulouse, France.

Purpose: Paediatric musculoskeletal injuries in association with increased participation in sports activities continue to increase. Arthroscopy is recognized as a safe and effective procedure in children. This study aims to identify trends in European paediatric sports centres over 20 years.

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Background: Following mild traumatic brain injury (mTBI), elevated concentrations of brain-specific blood proteins glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) may be indicative of intracranial lesions normally detected by head CT scans. We sought to validate the performance of this combination of biomarkers at predetermined cutoff values with an automated immunoassay to predict which patients did not have intracranial lesions.

Methods: This prospective, observational study was conducted in France and Spain at 16 emergency departments.

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Article Synopsis
  • The study focuses on the osteochondral interface, which includes calcified cartilage (CC) and subchondral bone (SCB), and presents a new method for analyzing chondrocyte and osteocyte lacunae in human knee samples using advanced imaging techniques.
  • Researchers employed a combination of a marker-controlled watershed algorithm and deep learning (specifically nnU-Net) to enhance the 3D segmentation of cell lacunae, effectively improving the assessment of their structures.
  • Findings showed that while chondrocyte characteristics didn't differ significantly between control and osteoarthritic knees, osteocytes in the osteoarthritic group exhibited lower anisotropy and tended to be more spherical,
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Article Synopsis
  • * A systematic review of recent literature (2022-2024) was undertaken to evaluate diagnostic and treatment methods, providing evidence-based recommendations.
  • * Key recommendations include using MRI before biopsies, considering transperineal biopsies to lower infection risks, and active surveillance for low-risk tumors to enhance patient management.
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Purpose Of This Document: The Oncology Committee of the French Urology Association is proposing updated recommendations for the management of recurrent and/or metastatic prostate cancer (PCa).

Methods: A systematic review of the literature from 2022 to 2024 was conducted by the CCAFU on the therapeutic management of recurrent PCa following local or metastatic treatment, assessing the references based on their level of evidence.

Results: Molecular imaging is the standard approach for assessing recurrence after local treatment and should not delay early salvage treatment.

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Objectives: To analyse peripapillary and papillary superficial microvascularization using OCT-angiography (OCT-A) in patients with non-arteritic ischaemic optic neuropathy (NAION) at the acute and resolutive stages.

Methods: This retrospective case-control study conducted between October 2018 and November 2019 included 23 NAION subjects at the acute stage (onset <1 month) and 20 patients at the resolutive stage (onset >3 months). NAION and contralateral eyes were compared to control eyes of patients (n = 50) matched 1:1 for refractive error, sex, age, systemic hypertension, diabetes, and sleep apnoea syndrome.

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Drug-induced spontaneous coronary artery dissection: Analysis of the World Health Organization's pharmacovigilance database.

Arch Cardiovasc Dis

November 2024

Department of Medical and Clinical Pharmacology, Centre of PharmacoVigilance and Pharmacoepidemiology, Faculty of Medicine, Toulouse University Hospital (CHU), 37, allées Jules-Guesde, 31000 Toulouse, France; Team Pharmacologie En Population cohorteS et biobanqueS (PEPSS), centre d'investigation clinique 1436, Toulouse University Hospital (CHU), 31000 Toulouse, France. Electronic address:

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Questionnaire on sustainability practices in French rhythmology departments.

Arch Cardiovasc Dis

November 2024

Cardiology Department, Grenoble Alpes University, Grenoble Alpes University Hospital, 38043 Grenoble, France.

Background: On the one hand, climate change affects health and healthcare systems worldwide. On the other hand, the healthcare system contributes to environmental pollution. These environmental issues concern rhythmology, particularly because of the use of complex, often plastic, single-use devices.

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Development of locus-specific approaches targeting precise regions on chromatin, for locus/transcription visualization or transcription/epigenetic marks editing, is a critical challenge in functional genetics and epigenetics. Systems engineered from the clustered regularly interspaced short palindromic repeats (CRISPR) and its associated endonuclease (Cas) operate through DNA sequence-specific recognition by so-called guide RNAs, which provides high flexibility and modularity for precise chromatin visualization or edition. Here, we provide an overview of the CRISPR/Cas-derived tools developed for visualization of chromatin loci in live imaging or for effective modification of gene expression.

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Histone dynamics constitute an important layer of gene regulations associated with development and growth in multicellular eukaryotes. They also stand as key determinants of plant responses to environmental changes. Histone dynamics include the exchange of histone variants as well as post-translational modifications of their amino acid residues (such as acetylation and mono/di/trimethylation), commonly referred to as histone marks.

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