2,085 results match your criteria: "Grenoble-Alpes University[Affiliation]"
Pediatr Allergy Immunol
December 2024
French National Reference Center for Angioedema (CREAK), Center of Excellence and Reference (ACARE), Internal Medicine Department, Grenoble Alpes University Hospital, Grenoble, France.
Background: Hereditary angioedema (HAE) in children has specific features and requires multidisciplinary management.
Methods: We performed a literature search and underwent in-depth discussions to provide practical tools for physicians.
Results: HAE is a rare, life-threatening genetic disorder.
Eur J Intern Med
December 2024
Department of Hematology, Grenoble Alpes University Hospital, Grenoble, France; Institute for Advanced Bioscience, Grenoble Alpes University, Grenoble, France. Electronic address:
Diagn Interv Radiol
December 2024
Nîmes University Hospital, Department of Medical Imaging, Nîmes, France.
J Med Vasc
December 2024
Vascular Medicine Department, Toulouse University Hospital, Toulouse, France.
Venous thromboembolism (VTE) rarely occurs during childhood and, with few exceptions, should be considered as a disease of sick children. Current recommendations concerning the duration of anticoagulant treatment for paediatric VTE are essentially based on the results of clinical trials conducted in adults. Yet the underlying medical conditions, incidence, and anatomical locations of the disease, as well as the rates of unprovoked VTE, morbidity, and mortality, differ between adults and children.
View Article and Find Full Text PDFCancer
January 2025
Department of Medical Oncology, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France.
Background: Nivolumab obtained approval in advanced melanoma (AM) with weight-adjusted dose (WAD) administration (3 mg/kg/2 weeks). In 2018, the dosage regimen was changed to flat dose (FD) administration (240 mg/2 weeks or 480 mg/4 weeks) based on a modeling study, without clinical data.
Methods: AM patients have been prospectively included in the French national multicenter MelBase database since 2013.
Hear Res
January 2025
Université Paris Cité, VIFASOM ERC 7330, Vigilance Fatigue Sommeil et Santé publique, Paris, France; APHP Hôtel-Dieu, Centre du Sommeil et de la Vigilance, Paris, France.
Background: Tinnitus, defined as the conscious awareness of a noise without any identifiable corresponding external acoustic source, can be modulated by various factors. Among these factors, tinnitus patients commonly report drastic increases of tinnitus loudness following nap sleep. Previous studies have suggested that this clinical pattern could be attributed to a somatosensory modulation of tinnitus.
View Article and Find Full Text PDFSleep Med
November 2024
Pediatric Noninvasive Ventilation and Sleep Unit, AP-HP, Hôpital Necker-Enfants Malades, F-75015, Paris, France; Université de Paris Cité, EA 7330 VIFASOM, F-75004, Paris, France. Electronic address:
Purpose: The aim of the study was to analyze the characteristics of otherwise healthy children with obstructive sleep apnea (OSA; OSA-I) and children with OSA and non-syndromic obesity (OSA-II) treated with long term continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) in 2019 in France.
Methods: Data were collected from a national survey on paediatric home noninvasive ventilatory support. CPAP/NIV initiation criteria and duration, age at CPAP/NIV initiation, equipment used and CPAP/NIV settings, and objective compliance were analyzed.
Tech Coloproctol
December 2024
Univ. Grenoble-Alpes, CNRS, Grenoble INP, TIMC, 38000, Grenoble, France.
Drug Saf
December 2024
Service d'Audiologie and d'Explorations Otoneurologiques, Hospices Civils de Lyon, Lyon, France.
Introduction: Improving adverse events following immunisation (AEFI) detection is vital for vaccine safety surveillance, as an early safety signal can help minimize risks. In February 2022, the World Health Organization reported a preliminary signal on sudden sensorineural hearing loss (SSNHL) following coronavirus disease 2019 (COVID-19) vaccination, 54 million persons in France received at least one dose, covering 78.8% of the population within a year.
View Article and Find Full Text PDFWorld J Urol
December 2024
Department of Urology, APHM, North Academic Hospital, Marseille, France.
iScience
December 2024
University Grenoble Alpes, Inserm 1209, CNRS 5309, Institute for Advanced Biosciences, F38000 Grenoble, France.
Li-Fraumeni syndrome (LFS) is a heterogeneous predisposition to an individually variable spectrum of cancers caused by pathogenic germline variants. We used a clustering method to assign TP53 missense variants to classes based on their functional activities in experimental assays assessing biological p53 functions. Correlations with LFS phenotypes were analyzed using the public germline mutation database and validated in three LFS clinical cohorts.
View Article and Find Full Text PDFClin Rehabil
December 2024
ThEMAS Team, TIMC Laboratory, UMR CNRS-UGA, 5525, Université Grenoble Alpes, Saint-Martin-d'Heres, France.
Heliyon
November 2024
Grenoble Alpes University, CNRS, Grenoble INP, Néel Institute, 38000, Grenoble, France.
ACS Omega
November 2024
Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41 Dinh Tien Hoang, District 1, Ho Chi Minh City 700000, Vietnam.
In the development of anticancer medications, vascular endothelial growth factor receptor 2 (VEGFR-2), which belongs to the protein tyrosine kinase family, emerges as one of the most significant targets of interest. The ongoing Food and Drug Administration (FDA) approval of novel therapeutic medicines toward VEGFR-2 emphasizes the urgent need to discover sophisticated molecular structures that are capable of reliably limiting VEGFR-2 activity. Recognizing the huge potential of deep-learning-based molecular model advancements, we focused our study on exploring the chemical space to find small molecules potentially inhibiting VEGFR-2.
View Article and Find Full Text PDFJ Child Orthop
November 2024
Pediatric Orthopedic Department, Hôpital des Enfants de Toulouse, Toulouse, France.
Purpose: Paediatric musculoskeletal injuries in association with increased participation in sports activities continue to increase. Arthroscopy is recognized as a safe and effective procedure in children. This study aims to identify trends in European paediatric sports centres over 20 years.
View Article and Find Full Text PDFArch Cardiovasc Dis
November 2024
Cardiology Department, Hôpital Rangueil, CHU de Toulouse, 31400 Toulouse, France; Inserm UMR 1297, I2MC, 31432 Toulouse, France.
EBioMedicine
December 2024
Department of Anaesthesia and Intensive Care, University Grenoble Alpes, Centre Hospitalier Universitaire de Grenoble, Grenoble Alpes, France; Grenoble Institut des Neurosciences, INSERM, U1216, Grenoble, France.
Background: Following mild traumatic brain injury (mTBI), elevated concentrations of brain-specific blood proteins glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) may be indicative of intracranial lesions normally detected by head CT scans. We sought to validate the performance of this combination of biomarkers at predetermined cutoff values with an automated immunoassay to predict which patients did not have intracranial lesions.
Methods: This prospective, observational study was conducted in France and Spain at 16 emergency departments.
Sci Rep
November 2024
Paris Cité University CNRS INSERM, B3OA, UMR 7052, U 1271, 10 avenue de Verdun, Paris, 75010, France.
Fr J Urol
November 2024
11, rue Viète, 75017 Paris, France.
Fr J Urol
November 2024
11, rue Viète, 75017 Paris, France.
Purpose Of This Document: The Oncology Committee of the French Urology Association is proposing updated recommendations for the management of recurrent and/or metastatic prostate cancer (PCa).
Methods: A systematic review of the literature from 2022 to 2024 was conducted by the CCAFU on the therapeutic management of recurrent PCa following local or metastatic treatment, assessing the references based on their level of evidence.
Results: Molecular imaging is the standard approach for assessing recurrence after local treatment and should not delay early salvage treatment.
Eye (Lond)
November 2024
Department of Ophthalmology, University Hospital of Grenoble-Alpes, Grenoble, France.
Objectives: To analyse peripapillary and papillary superficial microvascularization using OCT-angiography (OCT-A) in patients with non-arteritic ischaemic optic neuropathy (NAION) at the acute and resolutive stages.
Methods: This retrospective case-control study conducted between October 2018 and November 2019 included 23 NAION subjects at the acute stage (onset <1 month) and 20 patients at the resolutive stage (onset >3 months). NAION and contralateral eyes were compared to control eyes of patients (n = 50) matched 1:1 for refractive error, sex, age, systemic hypertension, diabetes, and sleep apnoea syndrome.
Arch Cardiovasc Dis
November 2024
Department of Medical and Clinical Pharmacology, Centre of PharmacoVigilance and Pharmacoepidemiology, Faculty of Medicine, Toulouse University Hospital (CHU), 37, allées Jules-Guesde, 31000 Toulouse, France; Team Pharmacologie En Population cohorteS et biobanqueS (PEPSS), centre d'investigation clinique 1436, Toulouse University Hospital (CHU), 31000 Toulouse, France. Electronic address:
Arch Cardiovasc Dis
November 2024
Cardiology Department, Grenoble Alpes University, Grenoble Alpes University Hospital, 38043 Grenoble, France.
Background: On the one hand, climate change affects health and healthcare systems worldwide. On the other hand, the healthcare system contributes to environmental pollution. These environmental issues concern rhythmology, particularly because of the use of complex, often plastic, single-use devices.
View Article and Find Full Text PDFMethods Mol Biol
November 2024
Grenoble Alpes University-CNRS-INRAE-CEA, Plant and Cell Physiology Lab (LPCV), IRIG-DBSCI, Grenoble, France.
Development of locus-specific approaches targeting precise regions on chromatin, for locus/transcription visualization or transcription/epigenetic marks editing, is a critical challenge in functional genetics and epigenetics. Systems engineered from the clustered regularly interspaced short palindromic repeats (CRISPR) and its associated endonuclease (Cas) operate through DNA sequence-specific recognition by so-called guide RNAs, which provides high flexibility and modularity for precise chromatin visualization or edition. Here, we provide an overview of the CRISPR/Cas-derived tools developed for visualization of chromatin loci in live imaging or for effective modification of gene expression.
View Article and Find Full Text PDFMethods Mol Biol
November 2024
Grenoble Alpes University-CNRS-INRAE-CEA, Plant and Cell Physiology Lab (LPCV), IRIG-DBSCI, Grenoble, France.
Histone dynamics constitute an important layer of gene regulations associated with development and growth in multicellular eukaryotes. They also stand as key determinants of plant responses to environmental changes. Histone dynamics include the exchange of histone variants as well as post-translational modifications of their amino acid residues (such as acetylation and mono/di/trimethylation), commonly referred to as histone marks.
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