1,164 results match your criteria: "Grenoble university hospital[Affiliation]"

Membranous nephropathy constitutes approximately 20% of adult nephrotic syndrome cases. In approximately 80% of cases, membranous nephropathy is primary, mediated by IgG autoantibodies primarily targeting podocyte antigens (PLA2R, THSD7A, etc.).

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Analyzing the impact of phthalate and DINCH exposure on fetal growth in a cohort with repeated urine collection.

Environ Int

April 2024

University Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, 38000, Grenoble, France.

Article Synopsis
  • This study evaluated the links between urinary phthalate metabolite levels in pregnant women and fetal growth, measuring outcomes at two different stages of pregnancy and at birth.
  • Researchers analyzed urine samples from 484 women and performed ultrasound measurements of fetal growth parameters to assess potential links.
  • Results indicated that while no connection was found with birth weights, certain phthalates (MiBP and MnBP) were positively associated with fetal growth measurements taken during the second and third trimesters, suggesting potential periods of vulnerability related to phthalate exposure.
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Sjögren's syndrome (SS) is a systemic autoimmune pathology manifested mainly by a dry syndrome, intense asthenia and arthromyalgia. Systemic manifestations may also occur. Since 2019, immunosuppressant agents (IS) or biotherapies are recommended only for patients with systemic involvement.

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Objective: We investigated maternal and paternal sleep evolution from 3 to 36 months postpartum, their interrelations and predictors in the SEPAGES cohort.

Methods: Sleep information (night sleep duration [NSD], weekend daytime sleep duration [DSD] and subjective sleep loss [SSL]) was collected by self-administered questionnaires at 3, 18, 24 and 36 months postpartum in the SEPAGES French cohort that included 484 mothers and 410 fathers. Group-based multi-trajectory modelling was used to identify maternal, paternal and couple sleep multi-trajectory groups among 188 couples reporting sleep data for at least 2 time points.

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Purpose: To assess the feasibility and technical accuracy of performing pedicular screw placement combined with vertebroplasty in the radiological setting.

Methods: Patients who underwent combined vertebroplasty and pedicle screw insertion under combined computed tomography and fluoroscopic guidance in 4 interventional radiology centers from 2018 to 2023 were retrospectively assessed. Patient demographics, vertebral lesion type, and procedural data were analyzed.

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Interventional Oncology (IO) stands at the forefront of transformative cancer care, leveraging advanced imaging technologies and innovative interventions. This narrative review explores recent developments within IO, highlighting its potential impact facilitated by artificial intelligence (AI), personalized medicine and imaging innovations. The integration of AI in IO holds promise for accelerating tumour detection and characterization, guiding treatment strategies and refining predictive models.

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Early hybrid cardiac rehabilitation in congenital heart disease: the QUALIREHAB trial.

Eur Heart J

April 2024

Pediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Montpellier University Hospital, Montpellier, France.

Background And Aims: Cardiopulmonary fitness in congenital heart disease (CHD) decreases faster than in the general population resulting in impaired health-related quality of life (HRQoL). As the standard of care seems insufficient to encourage and maintain fitness, an early hybrid cardiac rehabilitation programme could improve HRQoL in CHD.

Methods: The QUALIREHAB multicentre, randomized, controlled trial evaluated and implemented a 12-week centre- and home-based hybrid cardiac rehabilitation programme, including multidisciplinary care and physical activity sessions.

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Tissue engineering strategies for breast reconstruction: a literature review of current advances and future directions.

Ann Transl Med

February 2024

Vascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background And Objective: Mastectomy is a primary treatment for breast cancer patients, and both autologous and implant-based reconstructive techniques have shown excellent results. In recent years, advancements in bioengineering have led to a proliferation of innovative approaches to breast reconstruction. This article comprehensively explores the promising perspectives offered by bioengineering and tissue engineering in the field of breast reconstruction.

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Background: Chronic spontaneous urticaria (CSU) is unpredictable and can severely impair patients' quality of life. Patients with CSU need a convenient, user-friendly platform to complete patient-reported outcome measures (PROMs) on their mobile devices. CRUSE , the Chronic Urticaria Self Evaluation app, aims to address this unmet need.

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Autoimmune cytopenia (AIC) in children may be associated with positive antinuclear antibodies (ANA) and may progress to systemic lupus erythematosus (SLE). We evaluated the risk of progression to SLE of childhood-onset ANA-associated AIC. In the French national prospective OBS'CEREVANCE cohort, the long-term outcome of children with ANA-associated AIC (ANA titer ≥1/160) and a subgroup of children who developed SLE were described.

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IL-6 and SAA-Strong Predictors for the Outcome in COVID-19 CKD Patients.

Int J Mol Sci

December 2023

Nephrology, Hemodialysis, Apheresis and Kidney Transplantation Department, Grenoble University Hospital, 38043 Grenoble, France.

In this prospective study, we assessed biomarkers of inflammation (IL-6 and SAA) from the serum of 120 COVID-19 patients, of whom 70 had chronic kidney disease. All the samples were taken at emergency-department (ED) admission. Our goal was to relate the biomarkers to the results of death and acute kidney injury.

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Introduction: High-flow nasal cannula (HFNC) is commonly used as first step respiratory support in infants with moderate-to-severe acute viral bronchiolitis (AVB). This device, however, fails to effectively manage respiratory distress in about a third of patients, and data are limited on determinants of patient response. The respiratory rate-oxygenation (ROX) index is a relevant tool to predict the risk for HFNC failure in adult patients with lower respiratory tract infections.

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Article Synopsis
  • The study investigated the incidence and costs associated with cardiovascular renal diseases (CVRD) among people with type 2 diabetes who did not have a history of CVRD, using a cohort of over 2 million individuals in France for 5 years.
  • Results showed that 15.3% of participants developed a CVRD manifestation within 5 years, with chronic kidney disease (CKD) being the most common (40.6%), followed by heart failure (HF) and peripheral arterial disease (PAD).
  • The total hospitalization costs for CVRD over the 5 years were estimated at 3.9 billion euros, with CKD accounting for the largest share of the costs (2 billion euros), indicating a significant economic burden in
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Aims: We analysed longitudinal blood pressure (BP) data from hypertensive obstructive sleep apnoea (OSA) patients in the European Sleep Apnea Database cohort. The study investigated the interaction between positive airway pressure (PAP)-induced BP change and antihypertensive treatment (AHT).

Methods And Results: Hypertensive patients with AHT [monotherapy/dual therapy = 1283/652, mean age 59.

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Background: Endometriosis is a chronic disease characterized by growth of endometrial tissue outside the uterine cavity which could affect 200 million women (The term "woman" is used for convenience. Individuals gendered as man or as nonbinary can also suffer from this disease) worldwide. One of the most common symptoms of endometriosis is pelvic chronic pain associated with fatigue.

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Article Synopsis
  • This study aimed to assess the effectiveness and safety of ethanol lock therapy (ELT) versus vancomycin lock therapy (VLT) for treating infections in totally implantable venous access devices (TIVAD) caused by coagulase-negative staphylococci.
  • Results showed a treatment success rate of 58.1% for the ELT group and 46.7% for the VLT group, with no significant difference in failure rates between the two therapies.
  • The study concluded that both therapies had high treatment failure rates, and emphasizes that removing the TIVAD device is crucial to avoid complications, except in rare cases.
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Objective: The International Union of Phlebology recommends measuring at least D-dimer and fibrinogen levels in the diagnosis of extensive extra-truncular venous malformations, with a surface area of 10 cm or those which are deep, as well as prior to any interventional procedure. The aim of the study was to characterise venous malformations associated with a possible vascular complication.

Method: This study was an observational and multicentre study.

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Background: Biological therapies have revolutionized the treatment of severe asthma with type 2 inflammation. Although such treatments are very effective in reducing exacerbation and the dose of oral steroids, little is known about the persistence of symptoms in severe asthma patients treated with biologics.

Purpose: We aim to describe asthma control and healthcare consumption of severe asthma patients treated with biologics.

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Evaluate the impact of the MiniMed™ 780G advanced hybrid closed-loop (AHCL) system on the glucose profile of pregnant women with type 1 diabetes (T1D) and maternal-neonatal complications. From April 2021 to September 2022, pregnant women with T1D treated with the AHCL system were included in an observational multicenter retrospective study. Continuous glucose monitoring parameters were analyzed monthly during pregnancy as well as maternal-neonatal complications.

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Information provision and follow-up of French patients with implantable cardioverter-defibrillators: The APODEC survey.

Arch Cardiovasc Dis

December 2023

Cardiology-Heart Rhythm Management Department, Clinique Pasteur, 31076 Toulouse, France; Vrije Universiteit Brussel (VUB), 1050 Brussels, Belgium. Electronic address:

Background: Implantable cardioverter-defibrillators reduce mortality, but the electric shocks delivered can impact the patient's quality of life. Patient education is an efficient way to reduce the stress related to both the device and the disease.

Aims: We assessed the evolution of knowledge and satisfaction of implantable cardioverter-defibrillator recipients regarding their cardiac disease, implantable cardioverter-defibrillator implantation, follow-up complications, remote monitoring and daily life recommendations.

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