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Structural chromatin alterations in peripheral blood leukocytes of alcohol-dependent individuals during detoxification therapy.
In Vivo
February 2015
Research Unit of Histochemistry and Electron Microscopy, First Department of Psychiatry, University of Athens, Medical School, Eginition Hospital, Athens, Greece Neurobiology Research Institute, Theodor Theohari Cozzika Foundation, Athens, Greece.
Article Synopsis
- The study aimed to explore chromatin condensation in the blood cells of alcoholics during early detoxification, focusing on potential epigenetic changes linked to alcohol use.
- Blood samples were analyzed from both alcoholics undergoing detox and healthy individuals, using specific staining techniques to assess chromatin structure.
- The findings showed that alcoholics had more relaxed chromatin in their lymphocytes and neutrophils, suggesting heightened genomic reactivity even in the detox phase, and highlighted leukocyte chromatin structure as a valuable marker for epigenetic research in chronic alcoholics.