Nutritional, Chemical, Antioxidant and Antibacterial Screening of L. and L. Different Morphological Parts.

The chemical composition and biological activity of and are scarcely investigated. In this study, the nutritional and chemical profiles of and , considering their different morphological parts (leaves, fruits and roots), were assessed together with their antioxidant and antibacterial potential. Our results showed that carbohydrates are the major macronutrients in both species (above 62 g/100 g dry weight-DW).

Prevalence, Characterization, and Proteomic Relatedness Among β-Lactam-Resistant Bacteria Throughout the Poultry Production Chain in Greece.

Extended-spectrum-β-lactamase (ESBL) and carbapenemase-producing , and spp. are associated with hospital-acquired infections and are commonly isolated across the poultry food production chain. Comprehensive data regarding the prevalence, spatiotemporal variations, and characterization of β-lactam-resistant bacteria in poultry farms and slaughterhouses is scarce.

Automated AI-based image analysis for quantification and prediction of interstitial lung disease in systemic sclerosis patients.

Background: Systemic sclerosis (SSc) is a rare connective tissue disease associated with rapidly evolving interstitial lung disease (ILD), driving its mortality. Specific imaging-based biomarkers associated with the evolution of lung disease are needed to help predict and quantify ILD.

Methods: We evaluated the potential of an automated ILD quantification system (icolung) from chest CT scans, to help in quantification and prediction of ILD progression in SSc-ILD.

NONAN GaitPrint: An IMU gait database of healthy older adults.

The continued effort to study gait kinematics and the increased interest in identifying individuals based on their gait patterns could be strengthened by the inclusion of data from older groups. To address this need and complement our previous database on healthy young adults, we present an addition to the Nonlinear Analysis Core (NONAN) GaitPrint database. We offer full-body inertial measurement data during self-paced overground walking on a 200 m indoor track of 41 older adults (56 + years old; 20 men and 21 women; age: 64.

Calibration and Zeta Functions for the Wacom DTU1141b.

To accurately examine and compare Digitally Captured Signature data, the provided data channels (X, Y, F and T) need to be expressed in comparable units. The Force channel data is routinely expressed in unnormalized Pressure Levels hindering the accurate comparison between data collected from different devices. The normalization method using the Zeta Function is used to calibrate and calculate the Zeta Functions of the Wacom DTU1141b.

Characteristics of children and adolescents with multidrug-resistant and rifampicin-resistant tuberculosis and their association with treatment outcomes: a systematic review and individual participant data meta-analysis.

Background: There are few data on the treatment of children and adolescents with multidrug-resistant (MDR) or rifampicin-resistant (RR) tuberculosis, especially with more recently available drugs and regimens. We aimed to describe the clinical and treatment characteristics and their associations with treatment outcomes in this susceptible population.

Methods: We conducted a systematic review and individual participant data meta-analysis.

CT perfusion and MRI: A combined approach for hepatocellular carcinoma diagnosis and follow-up after locoregional treatment.

Objective: CT liver perfusion (CTLP) has been well validated for hepatocellular carcinoma (HCC) detection, characterization, and treatment response evaluation. However, its role in HCC management algorithms remains unclear. This study aims to assess the diagnostic performance of CTLP alone or as an adjunct to MRI in patients considered for- or undergoing locoregional treatment for HCC.

The role of non-respiratory arousals in residual daytime sleepiness in patients with obstructive sleep apnea treated with positive airway pressure: An analysis of the European Sleep Apnea Database registry.

Study Objectives: To assess the impact of the non-respiratory arousal burden at baseline polysomnography (PSG) on residual daytime sleepiness in positive airway pressure (PAP)-treated obstructive sleep apnea (OSA).

Methods: We included OSA patients from the European Sleep Apnea Database registry with available arousal data who had at least 2 treatment follow-up visits. The primary outcome was the Epworth Sleepiness Scale (ESS) score under PAP.

Investigating the application of novel filling materials in Vertical Subsurface Flow Constructed Wetlands for the treatment of anaerobic effluents originating from domestic wastewater.

Vertical subsurface flow constructed wetlands (VSSF CWs) were employed to investigate the use of biochar that could be produced with local agricultural biomass through pyrolysis, recycled glass from local recycling companies and gel beads with decreased packing volume and shipping cost as substrate alternatives to sand. The materials were assessed in terms of granulometry, porosity, adsorption capacity and hydraulic conductivity and were used for the treatment of an upflow anaerobic sludge blanket (UASB) reactor, treating domestic wastewater, effluent. Granulometry was a major factor impacting TSS removal that ranged from 81% ± 10% to 97% ± 2%.

The 2024 Assisi think tank on breast cancer: Focus on the use of a tumour bed boost after breast conserving therapy.

At the Fifth Assisi Think Tank Meeting (ATTM) on breast cancer, one key topic was the role of tumor bed boost in invasive breast cancer and ductal carcinoma in situ. The need for a tumor bed boost after whole breast irradiation is controversial. A literature review assessed boost indications, target volume definition, techniques, dose fractionation, and ongoing trials.

A rare morphological variant: Bilateral accessory optic canal.

The optic canal (OC) transmits the optic nerve (ON) and ophthalmic artery (OA) from the skull base to the orbit. Its morphological variability is narrow, and most commonly its dimensions are being studied. We observed an unexpected variant during a routine investigation of our osteological collection.

Prevalence of FGFR2b Protein Overexpression in Advanced Gastric Cancers During Prescreening for the Phase III FORTITUDE-101 Trial.

Purpose: Fibroblast growth factor receptor 2 isoform IIIb (FGFR2b) protein overexpression is an emerging biomarker in gastric cancer and gastroesophageal junction cancer (GC). We assessed FGFR2b protein overexpression prevalence in nearly 3,800 tumor samples as part of the prescreening process for a global phase III study in patients with newly diagnosed advanced or metastatic GC.

Methods: As of June 28, 2024, 3,782 tumor samples from prescreened patients from 37 countries for the phase III FORTITUDE-101 trial (ClinicalTrials.

Dynamic Accommodation Responses in Subjects Wearing Myopia Control Spectacles Modifying Peripheral Refraction.

Purpose: Peripheral optics have been suggested to play a role in myopia progression, with accommodation responses also considered a potential contributor. This study aimed to investigate whether modifications in peripheral optics through different spectacle lenses affect accommodation responses.

Methods: Dynamic accommodation responses were assessed using a double-pass instrument while switching the target from distance (3 m for 3 seconds) to near (0.

Effects of Exercise Training on the Bone Marrow Immune Microenvironment and Minimal Residual Disease in Multiple Myeloma Patients Following First-Line Treatment.

The purpose of the study was to investigate the effects of exercise training on the bone marrow immune microenvironment and on minimal residual disease of multiple myeloma patients who completed first-line induction treatment. Eight multiple myeloma patients underwent 5 months of exercise training along with standard medical treatment. Eight age- and sex-matched patients who received medical treatment only, served as controls.

Overcoming low status or maintaining high status? A multinational examination of the association between socioeconomic status and honour.

We examined the relationship between socioeconomic status (SES) and endorsement of honour. We studied the SES-honour link in 5 studies (N = 13,635) with participants recruited in different world regions (the Mediterranean and MENA, East Asian, South-East Asian, and Anglo-Western regions) using measures that tap into various different facets of honour. Findings from these studies revealed that individuals who subjectively perceived themselves as belonging to a higher (vs.

SMARCB1-deficient malignant melanocytic uveal tumours: a new neural crest-derived tumour entity with SMARCB1-related germline predisposition.

Rhabdoid tumours (RT) are an aggressive malignancy affecting <2-year-old infants, characterised by biallelic loss-of-function alterations in SWI/SNF-related BAF chromatin remodelling complex subunit B1 (SMARCB1) in nearly all cases. Germline SMARCB1 alterations are found in ~30% of patients and define the RT Predisposition Syndrome type 1 (RTPS1). Uveal melanoma (UVM), the most common primary intraocular cancer in adults, does not harbour SMARCB1 alterations.

Different PD-L1 Assays Reveal Distinct Immunobiology and Clinical Outcomes in Urothelial Cancer.

Testing for PD-L1 expression by immunohistochemistry (IHC) is used to predict immune checkpoint blockade (ICB) benefit but has performed inconsistently in urothelial cancer (UC) clinical trials. Different approaches are used for PD-L1 IHC. We analyzed paired PD-L1 IHC data on UC samples using the SP142 and 22C3 assays from the phase 3 IMvigor130 trial and found discordant findings summarized by four phenotypes: PD-L1 positive by both assays (PD-L1 double positive; PD-L1DP), PD-L1 positive by the SP142 assay only (SP142 single positive; SP142SP), PD-L1 positive by the 22C3 assay only (22C3 single positive; 22C3SP), and PD-L1 negative by both assays double negative (PD-L1 double negative; PD-L1DN).

Use of and extracts as alternatives to organic filter in photoprotective formulations.

Recently, the cosmetic and pharmaceutical industries have aimed to reduce the concentration of EU-approved organic filters in their products by incorporating more natural ingredients. The goal is to find effective SPF boosters from plants while maintaining high protection levels and adhering to ecological and public health standards. This study focuses on developing a sunscreen formulation that replaces the organic filter EHMC (2-ethylhexyl-4-meth-oxycinnamate) with extracts from and/or oil.

The Global Secondary Metabolite Regulator Modulates Virulence, Ochratoxin Biosynthesis, and the Mode of Action of Biopesticides and Essential Oils.

is considered one of the main fungi responsible for black and sour rot in grapes, as well as the production of the carcinogenic mycotoxin ochratoxin A. The global regulatory methyltransferase protein controls the production of various secondary metabolites in species, as well as influences sexual and asexual reproduction and morphology. The goal of this study was to investigate the role of the regulatory gene in physiology, virulence, and ochratoxin A (OTA) production by deleting this gene from the genome of a wild-type strain.

Evaluating the Efficacy and Safety of Hepatitis E Vaccination in Reproductive-Age Women: A Systematic Review and Meta-Analysis.

Background: Hepatitis E virus (HEV) infection presents a significant health risk in endemic regions, especially for pregnant women, who face higher risks of severe complications, including maternal and fetal mortality. The recombinant HEV vaccine, HEV239, has demonstrated high efficacy in the general population, yet data on its safety and efficacy in women of a childbearing age remain limited. This systematic review and meta-analysis aim to evaluate the safety and effectiveness of HEV239 in this specific population, with a focus on pregnancy-related outcomes.

Rotavirus Vaccination Protects Against Diabetes Mellitus Type 1 in Children in Developed Countries: A Systematic Review and Meta-Analysis.

: The etiology of type 1 diabetes (T1D) remains an area of active research, with genetic and environmental factors being investigated. This meta-analysis aimed to determine if rotavirus vaccination influences the onset of T1D in children. : Following PRISMA 2020 guidelines, two researchers independently searched multiple databases, including PubMed and Google Scholar, for studies published in English from 2006 to September 2024.

Poor Nurses' Work Environment Increases Quiet Quitting and Reduces Work Engagement: A Cross-Sectional Study in Greece.

The nursing work environment, encompassing accessible resources and established processes, might affect nurses' professional behavior. Our aim was to examine the effect of nurses' work environments on quiet quitting and work engagement among nurses. We performed a cross-sectional study with nurses in Greece.