1,817 results match your criteria: "Granuloma Annulare"

Background And Objectives: Granuloma annulare (GA) is a noninfectious, granulomatous dermatosis that is generally localized and self-limiting. In 15% of cases, the disease disseminates with protracted trajectories. This study aims to characterise the patient population with disseminated GA at a German university hospital and to explore treatment modalities.

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Granuloma annulare (GA) is an idiopathic inflammatory skin condition with a chronic and unpredictable course. Although localized GA is usually cleared with topical or systemic corticosteroids, generalized GA is often difficult to treat owing to the lack of treatment options and recurrence with treatment. Recent evidence has helped to elucidate the etiology behind GA, with growing confirmation for the use of JAK inhibitors as a possible treatment for GA.

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Generalized granuloma annulare in a patient with human immunodeficiency virus infection.

Am J Med

December 2024

Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan. Electronic address:

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Granuloma Annulare of the Palms in a Patient on Ribociclib for Metastatic Breast Cancer.

Cureus

November 2024

Dermatology, North Branch Dermatology, Chicago, USA.

Granuloma annulare (GA) is a benign inflammatory skin condition that most commonly presents on the dorsal surfaces of the hands and feet. The etiology of GA is unknown; however, it has been associated with multiple triggers, including malignancy and targeted cancer therapy drugs. This case report describes a 66-year-old female with metastatic breast cancer on ribociclib who presented with painful, erythematous papules on the palmar surfaces of the hands.

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Article Synopsis
  • - Granuloma annulare (GA) is a rare inflammatory condition that primarily affects the skin, with subcutaneous forms being even less common.! - Familial cases of subcutaneous GA are very rare, with only a handful documented in medical literature.! - This text discusses a specific case involving two siblings who both experienced subcutaneous GA during their childhood.
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This case report describes a 34-year-old, HIV-positive, female referred to the hospital for treatment. The patient had widespread Kaposi sarcoma and a very low CD4-number. Prior to diagnosis, she had generalized granuloma annulare for six months, an incident of herpes zoster, and no sexual risk behaviour.

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Introduction: Generalized granuloma annulare (GA) is an uncommon noninfectious granulomatous dermatitis. Phototherapy is often considered first-line therapy, with more evidence for psoralen ultraviolet A than narrowband ultraviolet B (NB-UVB). We aimed to evaluate the effectiveness and safety of NB-UVB in generalized GA and to review the literature.

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Article Synopsis
  • Cutaneous reactions to mRNA COVID-19 vaccines can include various skin issues, especially in patients with existing dermatologic diseases.
  • A case report details a 73-year-old man with atopic dermatitis who developed severe erythroderma after each Pfizer-BioNTech vaccine dose, which covered 95% of his body.
  • Quick identification and treatment of erythroderma are crucial to prevent serious complications, highlighting the need for awareness of this reaction in susceptible individuals.
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Article Synopsis
  • Granuloma annulare is a harmless skin condition that isn't caused by an infection, and its exact cause involves complex immune system interactions that are still being studied.
  • The primary treatment options are usually steroid creams or injections, but these don't always work well or for a long time in every patient.
  • This text discusses a patient with chronic granuloma annulare who was successfully treated with tapinarof cream, a treatment option that hasn't been widely reported before.
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Erythema nodosum as first clinical sign of acute Borrelia burgdorferi infection.

Braz J Infect Dis

December 2024

Onkoderma- Clinic for Dermatology, Venereology and Dermatologic Surgery, Bulgaria; Department of Dermatology and Venereology, Medical Institute of Ministry of Interior, Bulgaria.

Article Synopsis
  • Lyme borreliosis, commonly known as Lyme disease, is a worldwide tick-borne infection caused by the Borrelia burgdorferi species, often starting with a distinctive erythema migrans rash at the bite site.
  • Other skin symptoms may also appear initially, leading to potential misdiagnosis and treatment delays, highlighting the need for comprehensive evaluation of clinical findings, serology, and histology.
  • A case of a 78-year-old woman revealed erythema nodosum as her initial manifestation following a tick bite; she was effectively treated with antibiotics and anti-inflammatory medications, and prescribed adjustments for her outpatient care.
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Article Synopsis
  • The COVID-19 pandemic raised significant healthcare issues and highlighted how the human immune system responds to viral infections and vaccinations.
  • This paper discusses two patients who experienced granulomatous skin lesions after receiving the COVID-19 vaccine, noting one had generalized granuloma annulare (GA) and the other had localized GA.
  • Both patients responded well to treatment with systemic corticosteroids, and the paper reviews related literature on skin diseases associated with COVID-19, focusing on potential mechanisms for these granulomatous skin eruptions.
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Successful treatment of actinic granuloma with intralesional steroid injection: a case report.

Acta Dermatovenerol Alp Pannonica Adriat

September 2024

Dermatologija Bartenjev, Ljubljana, Slovenia.

Actinic granuloma (AG) is a rare dermatological condition with only a few dozen cases reported worldwide. Initially classified as a variant of granuloma annulare, it is now recognized as a distinct entity characterized by asymptomatic annular plaques in sun-exposed areas of the skin. The exact pathogenesis remains unclear, but it is believed to be an inflammatory response to sun damage, possibly involving injured elastic fibers.

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Article Synopsis
  • Granuloma annulare (GA) is a skin condition that can be difficult to treat, particularly in its generalized form, and recent studies suggest tofacitinib may be effective for it.
  • In a study involving 15 patients with generalized GA, 11 achieved complete lesion clearance after an average of 4.4 months of treatment with tofacitinib, while the remaining had partial improvements.
  • Two patients experienced side effects like hyperlipidemia, but overall, tofacitinib proved to be a beneficial treatment, particularly for those who did not respond to standard therapies.
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  • Excimer light is a specialized form of NB-UVB therapy that operates at a 308 nm wavelength, allowing for targeted treatment of skin conditions.
  • It effectively treats conditions like psoriasis, vitiligo, and several other hard-to-treat skin diseases with minimal side effects.
  • The article discusses how excimer light works therapeutically and its applications in modern dermatology.
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Article Synopsis
  • A 47-year-old woman with several autoimmune and metabolic conditions presented with a painful skin rash characterized by raised, yellow-centered plaques on sun-exposed areas.
  • A biopsy revealed specific histopathological features that led to a diagnosis of annular elastolytic giant cell granuloma (AEGCG), a rare inflammatory skin disorder potentially triggered by sunlight exposure.
  • The patient showed significant improvement after being treated with ciclosporin, alleviating symptoms like itching and pain, highlighting the challenges in managing AEGCG, which is often resistant to standard treatments.
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Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders.

J Allergy Clin Immunol

November 2024

Department of Dermatology, Yale School of Medicine, New Haven, Conn; Department of Pathology, Yale School of Medicine, New Haven, Conn. Electronic address:

Article Synopsis
  • Noninfectious cutaneous granulomatous disorders like cutaneous sarcoidosis, granuloma annulare, necrobiosis lipoidica, and necrobiotic xanthogranuloma exhibit distinct immune responses and histological features due to variations in macrophage inflammation.
  • The study used spatial transcriptomics to analyze the immune activation patterns in these disorders, revealing that each condition has unique characteristics, such as polarized type 1 responses in cutaneous sarcoidosis and mixed type 1 and type 2 responses in granuloma annulare.
  • Findings suggest that different immune activation patterns are associated with specific histological changes, highlighting the complexity and individuality of these inflammatory skin conditions.
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Article Synopsis
  • Subcutaneous granuloma annulare (SGA) is a rare condition that primarily affects children, mostly presenting as painless subcutaneous nodules, with a median diagnosis age of 6.
  • A systematic review analyzed 97 studies involving 324 patients, revealing that while most have no comorbidities, diabetes was the most notable in 4% of cases.
  • Treatment options include surgical excision for 68.1% of patients, with a high rate of spontaneous resolution among those conservatively managed; intralesional steroids have shown promise, especially in non-resolving cases.
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Article Synopsis
  • - Granuloma annulare is a skin condition that features small, ring-shaped bumps with a normal center and can show different forms and connections to other health issues.
  • - A novel case was described where a young patient with granuloma annulare also experienced inflammatory granulomatous corneal disease, leading to vision problems and eye discomfort.
  • - The patient's eye issues improved completely with topical steroids, highlighting a rare link between this skin condition and eye problems that hasn't been reported before.
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Article Synopsis
  • A patient with FLT3 mutant acute myeloid leukemia showed no response to standard chemotherapy treatments.
  • Due to her specific gene mutations and risk factors, she was started on gilteritinib, a targeted therapy.
  • After beginning gilteritinib, she developed skin issues, which were successfully managed by reducing the gilteritinib dose and working with dermatologists.
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