6,141 results match your criteria: "Granular Cell Tumors"
Diagn Cytopathol
December 2024
Department of Pathology and Division of Diagnostic Pathology, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Granular cell tumors (GCTs) are relatively rare, whereas malignant GCTs are extremely rare. This brief report describes a cytological case of metastatic malignant GCT in the lymph node with immunocytochemical analysis. A 77 years old Japanese female with a history of surgical resection for malignant GCT in the back 8 years earlier presented with swelling of the right neck.
View Article and Find Full Text PDFClin Case Rep
December 2024
Division of Surgical Oncology, Department of Surgery Eastern Carolina Brody School of Medicine Greenville North Carolina USA.
Granular cell tumors (GCTs) are uncommon soft tissue neoplasms derived from Schwann cells that can arise from various regions of the body. The majority originate from the head and neck. They are rarely encountered in the gastrointestinal tract and even more rarely in the anorectal region.
View Article and Find Full Text PDFRare Tumors
December 2024
Department of pediatric surgery, Indira Gandhi Institute of Child Health, Bengaluru, India.
Granular cell tumors (GCT) are rare mesenchymal tumors belonging to Schwann cell lineage constituting 0.5% of all soft tissue neoplasms. They occur in skin, subcutaneous tissues, mucosal surfaces including within the deeper organs.
View Article and Find Full Text PDFCytoskeleton (Hoboken)
December 2024
Applied Physics Program, University of Michigan, Ann Arbor, Michigan, USA.
Tumor metastasis is a complex phenomenon that poses significant challenges to current cancer therapeutics. While the biochemical signaling involved in promoting motile phenotypes is well understood, the role of biomechanical interactions has recently begun to be incorporated into models of tumor cell migration. Specifically, we propose the unjamming transition, adapted from physical paradigms describing the behavior of granular materials, to better discern the transition toward an invasive phenotype.
View Article and Find Full Text PDFSAGE Open Med Case Rep
November 2024
Department of Pathology, University College of Medical Sciences, New Delhi, India.
Five cases of non-neuronal granular cell tumours of the oral cavity are documented in the literature. Additionally, one case of a non-neuronal granular cell tumour with features of malignancy was described. A malignant granular cell tumour is a rare neoplasm and counterpart of a benign granular cell tumour.
View Article and Find Full Text PDFClin J Gastroenterol
November 2024
Department of Gastroenterology, Tokyo Dental College, Ichikawa General Hospital, 5-11-13, Sugano, Ichikawa, Chiba, 272-8513, Japan.
We describe a case of gastric granular cell tumor (GCT) treated with laparoscopic and endoscopic cooperative surgery (LECS). A 30-year-old male was referred to our hospital for the investigation of a subepithelial lesion (SEL). Contrast-enhanced computed tomography and esophagogastroduodenoscopy revealed a 15 mm SEL within the posterior wall of the gastric body.
View Article and Find Full Text PDFFront Oncol
November 2024
Department of Orbital Surgery, Chongqing Aier Eye Hospital, Chongqing, China.
Clin Case Rep
November 2024
Department of Stomatology Beijing Friendship Hospital, Capital Medical University Beijing China.
Medicine (Baltimore)
November 2024
Department of Thoracic Surgery, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Acta Biomater
January 2025
Dentistry - Regenerative Biomaterials, Radboudumc, Philips van Leydenlaan 25, 6525 EX Nijmegen, the Netherlands; Radboud Institute for Medical Innovation, Radboudumc, Geert Grooteplein 21, 6525 EZ Nijmegen, the Netherlands. Electronic address:
Invasive bone tumors pose a significant healthcare challenge, often requiring systemic chemotherapy and limb salvage surgery. However, these strategies are hampered by severe side effects, complex post-resection bone defects, and high local recurrence rates. To address this, we developed dual-functional bone substitute biomaterials by functionalizing commercially available bone substitute granules (Bio-Oss® and MBCP®+) with the established anticancer agent cisplatin.
View Article and Find Full Text PDFBMC Gastroenterol
November 2024
Endoscopy Center, Zhongshan Hospital of Fudan University, Shanghai, 200032, China.
Background: To analyze the clinical manifestations, endoscopic features, pathological features, endoscopic resection, and prognosis of esophageal granular cell tumors (GCTs).
Methods: The present study retrospectively analyzed and followed up the clinical data of 62 patients diagnosed with esophageal GCTs who underwent endoscopic resection at Zhongshan Hospital of Fudan University between July 2007 and March 2022. The clinicopathological features, endoscopic diagnosis, and treatment experience of esophageal GCT patients were summarized.
Asian J Surg
November 2024
Department of Radiology, Zigong First People's Hospital, 643000, Zigong, PR China.
Mol Biol Rep
October 2024
Interdisciplinary Brain Research Centre, Faculty of Medicine, J. N. Medical College, Aligarh Muslim University, Aligarh, 202002, India.
Background: Medulloblastoma is a pediatric malignant brain tumor associated with an aberrantly activated Shh pathway. The Shh pathway acts via downstream effector molecules, including Pax6 and Nkx2.2.
View Article and Find Full Text PDFTunis Med
October 2024
Washington DC VA Medical Center, Department of Pathology, 20422, Washington, DC, USA.
Introduction: Granular cell tumors (GCT) are predominantly benign neoplasms composed by cells with abundant eosinophilic granular cytoplasm. Although the majority of GCTs exhibit a benign clinical course, a minority display cytological atypia and may exhibit aggressive, cancer-like behavior. Definitive evidence of malignancy in GCTs is reliably established only through the presence of metastasis.
View Article and Find Full Text PDFLab Invest
December 2024
Department of Neurosurgery, Houston Methodist Research Institute, Houston, Texas; Department of Neurological Surgery, University of Washington, Seattle, Washington; Department of Neurological Surgery, Weill Cornell Medicine, New York, New York.
Precision oncology is driven by biomarkers. For glioblastoma multiforme (GBM), the most common malignant adult primary brain tumor, O-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation is an important prognostic and treatment clinical biomarker. Time-consuming preanalytical steps such as biospecimen storage, fixation, sampling, and processing are sources of data irreproducibility, and all these preanalytical variables are confounded by intratumor heterogeneity of MGMT promoter methylation.
View Article and Find Full Text PDFEur Arch Otorhinolaryngol
October 2024
Barmherzige Brüder Klinikum St. Elisabeth Straubing, Klinik für Hals-Nasen-Ohren-Heilkunde mit Kopf-Hals- und plastischer Gesichtschirurgie, Straubing, Germany.
Turk J Pediatr
October 2024
Department of Pediatric Hematology and Oncology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Background: Aggressive natural killer cell leukemia (ANKL) is rare and difficult to diagnose in early stages, with no standard treatment and a poor prognosis.
Case Presentation: Two adolescents with ANKL presented with hemophagocytic lymphohistiocytosis (HLH), with Case-1 presenting as refractory HLH and Case-2 with lung involvement. The morphology of bone marrow showed an increase in unidentified cells, which mainly expressed CD56.
JAAD Case Rep
October 2024
Division of Dermatologic Surgery, Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
Clin Endosc
October 2024
Clinical Research Support Office, Aso Iizuka Hospital, Iizuka, Japan.
Pathol Res Pract
November 2024
Egyptian Ministry of Health, Tanta Ophthalmology Hospital, Tanta, Egypt. Electronic address:
Biofabrication
October 2024
Complex In-Vitro Models, GSK, Collegeville, PA, United States of America.
Front Oncol
September 2024
Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Asian J Surg
October 2024
Department of Neurosurgery, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, Shandong, China. Electronic address:
Front Genet
September 2024
Research Center, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Int J Surg Case Rep
November 2024
Department of Pathology, Chang Gung Memorial Hospital, Linkou Center, Taoyuan City, Taiwan.
Introduction: Pituitary spindle cell oncocytoma (PSCO) is a seldom-encountered type of pituitary neoplasm with distinctive histological features. It was first described as a distinct entity by Roncaroli et al. in 2002.
View Article and Find Full Text PDF