Association of mitochondrial respiratory chain enzymes with the risk and mortality of sepsis among Chinese children.

Background: Sepsis is a leading cause of pediatric morbidity and mortality worldwide. The aim of this study was to explore the association of decreased mitochondrial respiratory chain enzyme activities with the risk for pediatric sepsis, and explore their association with mortality among affected children.

Methods: A total of 50 incident cases with sepsis and 49 healthy controls participated in this study.

Vitamin D Receptor Is a Sepsis-Susceptibility Gene in Chinese Children.

BACKGROUND We designed an association study among 267 cases of children with sepsis and 283 healthy controls, by genotyping 9 variants in the VDR gene. MATERIAL AND METHODS This was a hospital-based, case-control, genetic association study. In addition to 3 genetic modes of inheritance, haplotype and interaction analyses were employed to examine the prediction of VDR gene for pediatric sepsis.

Roles and tissue source of adiponectin involved in lifestyle modifications.

Background: Calorie restriction and endurance exercise are known robust lifestyle modifications that delay the onset of type 2 diabetes and metabolic syndrome, however, its protective mechanism needs to be elucidated.

Methods: To investigate the role of adiponectin in lifestyle modifications, male Sprague-Dawley rats were divided into groups of caloric restriction, exercise, and control for a 6-month intervention. Tissue and serum adiponectin levels, tissue expression of SIRT1, AMP-activated protein kinase (AMPK)α phosphorylation and AdipoR1, and insulin sensitivity were determined.