2,526 results match your criteria: "Graduate School of Information Science[Affiliation]"

Coupling and uncoupling growth and product formation for producing chemicals.

Curr Opin Biotechnol

June 2024

Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, 1-5 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:

Article Synopsis
  • Microbial fermentation can be done using two main strategies: one where growth is linked to production (growth-coupled) and another where they are separate (nongrowth-coupled).
  • Utilizing stoichiometric metabolic models with flux balance analysis helps enhance the engineering processes for target synthesis, particularly in growth-coupled systems, which can also aid in overcoming production bottlenecks through evolution.
  • For cost-effective production of bulk chemicals, adopting a nongrowth-coupled approach is essential; this requires careful management of the transition from growth to production modes and ensuring cellular activity remains high even when not growing.
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Embedding Bifurcations into Pneumatic Artificial Muscle.

Adv Sci (Weinh)

July 2024

Graduate School of Information Science and Technology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan.

Harnessing complex body dynamics has long been a challenge in robotics, particularly when dealing with soft dynamics, which exhibit high complexity in interacting with the environment. Recent studies indicate that these dynamics can be used as a computational resource, exemplified by the McKibben pneumatic artificial muscle, a common soft actuator. This study demonstrates that bifurcations, including periodic and chaotic dynamics, can be embedded into the pneumatic artificial muscle, with the entire bifurcation structure using the framework of physical reservoir computing.

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Genomic Evidence for the Complex Evolutionary History of Macaques (Genus Macaca).

J Mol Evol

June 2024

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, Sichuan, People's Republic of China.

The genus Macaca is widely distributed, occupies a variety of habitats, shows diverse phenotypic characteristics, and is one of the best-studied genera of nonhuman primates. Here, we reported five re-sequencing Macaca genomes, including one M. cyclopis, one M.

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In this study, we investigate the effectiveness of noise reduction in electron holography, based on the wavelet hidden Markov model (WHMM), which allows the reasonable separation of weak signals from noise. Electron holography observations from a NdFeB thin foil showed that the noise reduction method suppressed artificial phase discontinuities generated by phase retrieval. From the peak signal-to-noise ratio, it was seen that the impact of denoising was significant for observations with a narrow spacing of interference fringes, which is a key parameter for the spatial resolution of electron holography.

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Infrared neural stimulation (INS) is a promising area of interest for the clinical application of a neuromodulation method. This is in part because of its low invasiveness, whereby INS modulates the activity of the neural tissue mainly through temperature changes. Additionally, INS may provide localized brain stimulation with less tissue damage.

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Necl-1/CADM3 regulates cone synapse formation in the mouse retina.

iScience

April 2024

Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0047, Japan.

Article Synopsis
  • The study investigates retinal neural circuitry in vertebrates, focusing on the outer plexiform layer where photoreceptors connect with bipolar and horizontal cells for visual perception.
  • It identifies Necl-1/CADM3 as a crucial factor for synapse formation between S- and S/M-opsin cones and type 4 OFF cone bipolar cells (CBCs) in the mouse retina.
  • Mice lacking Necl-1 displayed abnormal synapse positioning and impaired visual responses, indicating that Necl-1 plays a key role in facilitating OFF pathways for short-wavelength light processing.
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Plasma proteomics profile-based comparison of torso versus brain injury: A prospective cohort study.

J Trauma Acute Care Surg

October 2024

From the Department of Traumatology and Acute Critical Medicine (J.T., Y.T., H.M., T.M., H.O., J.O.), Osaka University Graduate School of Medicine; and Department of Bioinformatic Engineering (S.S.), Graduate School of Information Science and Technology, Osaka University, Osaka, Japan.

Background: Trauma-related deaths and posttraumatic sequelae are a global health concern, necessitating a deeper understanding of the pathophysiology to advance trauma therapy. Proteomics offers insights into identifying and analyzing plasma proteins associated with trauma and inflammatory conditions; however, current proteomic methods have limitations in accurately measuring low-abundance plasma proteins. This study compared plasma proteomics profiles of patients from different acute trauma subgroups to identify new therapeutic targets and devise better strategies for personalized medicine.

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Enhancement of neural crest formation by mechanical force in development.

Int J Dev Biol

April 2024

Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.

In vertebrate development, ectoderm is specified into neural plate (NP), neural plate border (NPB), and epidermis. Although such patterning is thought to be achieved by molecular concentration gradients, it has been revealed, mainly by analysis, that mechanical force can regulate cell specification. During patterning, cells deform and migrate, and this applies force to surrounding tissues, shaping the embryo.

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Spintronic virtual neural network by a voltage controlled ferromagnet for associative memory.

Sci Rep

April 2024

Graduate School of Information Science and Technology, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8656, Japan.

Article Synopsis
  • Researchers explored a virtual oscillator network using a single spintronic oscillator to address issues like inconsistencies in conventional neural networks based on real oscillators.
  • The proposed solution involves using a ferromagnet controlled by voltage-controlled magnetic anisotropy (VCMA) to minimize energy dissipation, reducing Joule heating from electric currents.
  • The study successfully demonstrated associative memory operations for recognizing alphabet patterns by linking colors in patterns to the sign of a magnetic anisotropy coefficient, which can be manipulated through the VCMA effect.
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The house shrew (. species complex) colonized regions across southern Asia and the Indian Ocean following human activity. The house shrew is distributed on islands of the Ryukyu Archipelago, the southernmost part of Japan, but the evolutionary history of the shrew on those islands and possible associations between these populations and humans remain unknown.

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Article Synopsis
  • * This study presents a novel VO nanowire network temperature sensor fabricated on a flexible film, achieving long-term stability (>110 hours) and high sensitivity of approximately -1.5%/°C.
  • * The use of machine learning for data interpolation among sensors enhances measurement accuracy and allows for tactile mapping without increasing the number of sensors needed.
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Regulation of muscle hypertrophy through granulin: Relayed communication among mesenchymal progenitors, macrophages, and satellite cells.

Cell Rep

April 2024

Laboratory of Stem Cell Regeneration and Adaptation, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan. Electronic address:

Article Synopsis
  • Skeletal muscles can adapt and regenerate in response to injury or mechanical stress, but the specific cellular mechanisms behind this adaptation are not well understood.
  • Researchers used single-cell RNA sequencing to analyze gene expression in overloaded muscles and found that the cellular makeup of overloaded muscles closely resembled that of regenerating muscles, especially during macrophage activity.
  • They discovered that granulin, a factor produced by macrophages, plays a significant role in inhibiting muscle satellite cell differentiation, and granulin-knockout mice had reduced muscle growth due to premature differentiation of those cells.
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Hierarchical structure growth across different length scales in the two-phase coexistence region of myristic acid Langmuir monolayers: correlation of static and dynamic heterogeneities.

Phys Chem Chem Phys

April 2024

Nanoelectronics Laboratory, Graduate School of Information Science and Technology, Hokkaido University, Sapporo, 060-0814, Japan.

We investigated the hierarchical structure growth of myristic acid monolayers at the air-water interface across different length scales in the two-phase coexistence region of the first order liquid expanded (LE)-liquid condensed (LC) phase transition. A combined study of surface pressure-area (π-) isotherm measurements with Brewster angle microscopy (BAM) observations was done at different temperatures. At the nanometer scale, the analysis of the π- isotherm by application of a thermodynamic cluster equation allowed us to obtain the π dependence of cluster size (cluster distribution) in the LE-LC coexistence region.

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The yield of a chemical reaction is obtained by solving its rate equation. This study introduces an approach for differentiating yields by utilizing the parameters of the rate equation, which is expressed as a first-order linear differential equation. The yield derivative for a specific pair of reactants and products is derived by mathematically expressing the rate constant matrix contraction method, which is a simple kinetic analysis method.

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Magnetic Phase Transition-Induced Modulation of Ferroelectric Properties in Hexagonal FeO ( = Tb and Ho).

ACS Appl Mater Interfaces

April 2024

Research Institute for Electronic Science, Hokkaido University, N20W10, Kita, Sapporo 001-0020, Japan.

Hexagonal rare-earth iron oxides (FeO) exhibit spontaneous magnetization and room-temperature ferroelectricity simultaneously. However, achieving a large magnetoelectric coupling necessitates further exploration. Herein, we report the impact of the magnetic phase transition on the ferroelectric properties of epitaxial FeO ( = Tb and Ho) films prepared by pulsed laser deposition.

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High-precision charge analysis in a catalytic nanoparticle by electron holography.

Microscopy (Oxf)

July 2024

Department of Applied Quantum Physics and Nuclear Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.

The charge state of supported metal catalysts is the key to understand the elementary processes involved in catalytic reactions. However, high-precision charge analysis of the metal catalysts at the atomic level is experimentally challenging. To address this critical challenge, high-sensitivity electron holography has recently been successfully applied for precisely measuring the elementary charges on individual platinum nanoparticles supported on a titanium dioxide surface.

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Multi-IRS-Assisted mmWave UAV-BS Network for Coverage Extension.

Sensors (Basel)

March 2024

Department of Electrical and Electronic Engineering, School of Engineering, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8552, Japan.

In the era of Industry 5.0, advanced technologies like artificial intelligence (AI), robotics, big data, and the Internet of Things (IoT) offer promising avenues for economic growth and solutions to societal challenges. Digital twin technology is important for real-time three-dimensional space reproduction in this transition, and unmanned aerial vehicles (UAVs) can support it.

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We focus on finding a correlation between the asymmetries of electroencephalography (EEG) signals and subjective well-being (SWB) when changed on short time scales via environmental conditions. Most research in this field focuses on frontal alpha asymmetry. We systematically examine different sensor locations and filter the sensor data into the delta band, the theta band, the alpha band, the beta band, and the gamma band, or leave the EEG signal unfiltered.

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We aimed to identify the steps involved in the Kumagai method-an experimental nursing procedure to feed children with cleft lip and/or palate, using a feeder with a long nipple. We conducted a descriptive study, enrolling five specialist nurses who have mastered the Kumagai method. Their approaches were examined using structured interviews.

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Development of the AI Pipeline for Corneal Opacity Detection.

Bioengineering (Basel)

March 2024

Graduate School of Information Science, University of Hyogo, Kobe Information Science Campus, Kobe 6500047, Japan.

Article Synopsis
  • Ophthalmological services are seriously lacking in low- and middle-income countries due to insufficient practitioners and equipment, particularly for addressing corneal opacity, a leading cause of blindness.
  • This study utilized a portable slit lamp microscope with video and cloud storage to improve global access to eye care, focusing on detecting corneal opacities through a two-part AI pipeline.
  • Manual annotation and advanced image processing techniques, including convolutional neural networks (CNN) and contrast enhancement, significantly boosted the accuracy of detecting corneal opacities, achieving impressive scores in both image frame analysis and semantic segmentation.
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An electrocardiogram (ECG) is used to observe the electrical activity of the heart via electrodes on the body surface. Recently, an ECG with fewer electrodes, such as a bipolar ECG in which two electrodes are attached to the chest, has been employed as wearable devices. However, the effect of different geometrical factors and electrode-pair locations on the amplitude and waveform of ECG signals remains unclear.

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The house mouse (), which is commensal to humans, has spread globally via human activities, leading to secondary contact between genetically divergent subspecies. This pattern of genetic admixture can provide insights into the selective forces at play in this well-studied model organism. Our analysis of 163 house mouse genomes, with a particular focus on East Asia, revealed substantial admixture between the subspecies and , particularly in Japan and southern China.

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Article Synopsis
  • This study examines the effects of tranexamic acid (TXA), an antifibrinolytic, on in-hospital mortality in blunt trauma patients across different clinical phenotypes using data from Japan.
  • Out of 80,463 trauma patients analyzed, 53,703 qualified for the study, with 8,046 receiving TXA treatment; certain trauma phenotypes showed reduced mortality rates with TXA, while others had increased mortality.
  • The findings highlight the potential for TXA to influence survival outcomes in trauma patients, necessitating further research to refine treatment criteria based on these clinical phenotypes.
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Lie Algebraic Quantum Phase Reduction.

Phys Rev Lett

March 2024

Department of Information and Communication Engineering, Graduate School of Information Science and Technology, The University of Tokyo, Tokyo 113-8656, Japan.

We introduce a general framework of phase reduction theory for quantum nonlinear oscillators. By employing the quantum trajectory theory, we define the limit-cycle trajectory and the phase according to a stochastic Schrödinger equation. Because a perturbation is represented by unitary transformation in quantum dynamics, we calculate phase response curves with respect to generators of a Lie algebra.

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On-the-fly Raman microscopy guaranteeing the accuracy of discrimination.

Proc Natl Acad Sci U S A

March 2024

Research Center of Mathematics for Social Creativity, Research Institute for Electronic Science, Hokkaido University, Sapporo 001-0020, Hokkaido, Japan.

Accelerating the measurement for discrimination of samples, such as classification of cell phenotype, is crucial when faced with significant time and cost constraints. Spontaneous Raman microscopy offers label-free, rich chemical information but suffers from long acquisition time due to extremely small scattering cross-sections. One possible approach to accelerate the measurement is by measuring necessary parts with a suitable number of illumination points.

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