The Association Between Longevity-Associated FOXO3 Allele and Heart Disease in Septuagenarians and Octogenarians: The SONIC Study.

The G allele of FOXO3 gene (single-nucleotide polymorphism; rs2802292) is strongly associated with human longevity. However, knowledge of the effect of FOXO3 in older populations, men or women, with heart disease is limited. This cross-sectional study in Japan included 1836 older adults in the 70- and 80-year-old groups.

A nationwide birth year-by-year analysis of effectiveness of HPV vaccine in Japan.

In Japan, the age-adjusted incidence of cervical cancer has been increasing constantly and rapidly among younger women. We set out to accurately confirm the effectiveness of the HPV vaccine in Japan. Data were collected for women born in the fiscal year (FY) 1990 to 1997, who became eligible for their 20-y-old cervical cancer screening between the FY 2010 to 2017.

The Number of Senders and Total Judgments Matter More Than Sample Size in Deception-Detection Experiments.

Hundreds of experiments have examined people's ability to distinguish truths from lies. Meta-analyses suggest that the findings from larger scale experiments converge and that findings discrepant from the meta-analytic average of 54% occur in only smaller experiments. Study size (number of data points, or total number of judgments) is a joint function of the sample size and the number of judgments per research participant.

Dohsa-hou intervention for reciprocal interpersonal interaction for a girl with Kabuki syndrome and autism spectrum disorder.

Although available evidence for psychosocial treatment for patients with Kabuki syndrome is limited, Dohsa-hou, a psychomotor therapy, could be a treatment option for autism spectrum disorder associated with the disorder.

Motivation for Rehabilitation in Patients With Subacute Stroke: A Qualitative Study.

Motivation is essential for patients with subacute stroke undergoing intensive rehabilitation. Although it is known that motivation induces behavioral changes toward rehabilitation, detailed description has been lacking. Motivation can be intrinsic or extrinsic; however, it is unclear which type of factors mainly motivates patients' daily rehabilitation.

CBSI as a Social Innovation to Promote the Health of Older People in Japan.

In this paper, we introduce a concept called community-based social innovation (CBSI). CBSI programs have been introduced to improve the physical and psychological well-being of older people. CBSI programs encourage older people to (1) take care of themselves and their peers, (2) sustain their well-being, and (3) create a cohesive and inclusive community.

Preverbal infants expect agents exhibiting counterintuitive capacities to gain access to contested resources.

Claims to supernatural power have been used as a basis for authority in a wide range of societies, but little is known about developmental origins of the link between supernatural power and worldly authority. Here, we show that 12- to 16-month-old infants expect agents exhibiting counterintuitive capacities to win out in a two-way standoff over a contested resource. Infants watched two agents gain a reward using either physically intuitive or physically counterintuitive methods, the latter involving simple forms of levitation or teleportation.

Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial.

Aim: Improving cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) has been regarded as a novel target for preventing cardiovascular disease. HDL reportedly has antioxidant properties which may contribute to its functions. We investigated changes in CEC with intake of the Japan Diet (JD) recommended by the Japan Atherosclerosis Society and the relationship of these changes to serum antioxidant concentrations.

Association of weekday-to-weekend sleep differences and stress response among a Japanese working population: a cross-sectional study.

Objectives: To investigate the relationship between differences in weekday-to-weekend sleep habits and stress responses in a working population.

Methods: This cross-sectional study used data from university workers on sleep habits, differences in sleep duration between weekdays and weekends, and each midpoint of the sleep phase on weekdays and weekends. Social jetlag was defined as the difference in the midpoint of the sleep phase between weekdays and weekends.

Assessing the Stiffness Perception of Acupressure Massage Beginning Learners: A Pilot Study.

Visually impaired licensed therapists must have the ability to perceive stiffness through their fingertips in the school for the blind. The teachers strive to provide careful introductory education based on a quantitative assessment of new students' basic stiffness perception. However, assessment materials to help teachers understand new students' stiffness perception are lacking.

Source memory and social exchange in young children.

Reciprocal interactions require memories of social exchanges; however, little is known about how we remember social partner actions, especially during childhood when we start forming peer-to-peer relationships. This study examined if the expectation-violation effect, which has been observed in adults' source memory, exists among 5-6-year-old children. Forty participants played a coin collection game where they either received or lost coins after being shown an individual with a smiling or angry expression.

A few prolific liars in Japan: Replication and the effects of Dark Triad personality traits.

Truth-Default Theory (TDT) predicts that across countries and cultures, a few people tell most of the lies, while a majority of people lie less frequently than average. This prediction, referred to as "a few prolific liars," is tested in Japan. The study further investigated the extent to which the Dark Triad personality traits predict the frequency of lying.

Disparity of Cervical Cancer Risk in Young Japanese Women: Bipolarized Status of HPV Vaccination and Cancer Screening.

Women born between 1994 and 1999 achieved high vaccination rates for human papillomavirus (HPV); they are now reaching the age of cervical cancer screening programs in Japan. In this study, we aimed to investigate the health awareness of HPV-vaccinated and unvaccinated women and to create tailored leaflets recommending cervical cancer screening for each. Surveys on the cancer screening rates for HPV-vaccinated and unvaccinated women aged 20 and 21 have demonstrated that the rate was significantly higher ( < 0.

The Economic Burden of Dementia: Evidence from a Survey of Households of People with Dementia and Their Caregivers.

Although a cognitive impairment such as dementia causes serious economic problems among older people, its impact on economic activities is unclear. This study investigated the actual conditions of economic activities and the current status of the financial support systems among people with dementia and caregivers. One hundred and five dyads participated in the survey.

Impact of occlusal force on decline in body mass index among older Japanese adults: Finding from the SONIC study.

Objectives: To determine any independent influence of occlusal force and of number of natural teeth on decline in body mass index (BMI) among older Japanese adults.

Design: Longitudinal study over a 3- to 6-year period.

Setting: Urban and rural area in Japan.

Association between physical function and onset of coronary heart disease in a cohort of community-dwelling older populations: The SONIC study.

Background: Physical function is a strong predictor of the adverse outcomes of cardiovascular disease in older populations. However, studies of healthy older people on the prevention of coronary heart disease (CHD) are very limited.

Objectives: We prospectively examined the association of walking speed and handgrip strength with CHD in the community-dwelling older populations.

Explanation of emotion regulation mechanism of mindfulness using a brain function model.

The emotion regulation mechanism of mindfulness plays an important role in the stress reduction effect. Many researchers in the fields of cognitive psychology and cognitive neuroscience have attempted to elucidate this mechanism by documenting the cognitive processes that occur and the neural activities that characterize each process. However, previous findings have not revealed the mechanism of information propagation in the brain that achieves emotion regulation during mindfulness.

Quercetin 3,5,7,3',4'-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1.

Sirtuin 1 (SIRT1), an NAD-dependent deacetylase, is a crucial regulator that produces multiple physiological benefits, such as the prevention of cancer and age-related diseases. SIRT1 is activated by sirtuin-activating compounds (STACs). Here, we report that quercetin 3,5,7,3',4'-pentamethyl ether (KPMF-8), a natural STAC from Thai black ginger Kaempferia parviflora, interacts with SIRT1 directly and stimulates SIRT1 activity by enhancing the binding affinity of SIRT1 with Ac-p53 peptide, a native substrate peptide without a fluorogenic moiety.

Effects of the Attention Training Technique on Brain Activity in Healthy University Students Assessed by EEG Source Imaging.

This study aimed to investigate the neurocognitive effects of the Attention Training Technique (ATT) on brain activity in healthy participants. The participants included 20 university students who were asked to practice ATT as a homework assignment for 20 days. The intracerebral source localization of their electroencephalogram during rest and the ATT task, which comprised selective attention, attention switching, and divided attention conditions, was evaluated by standardized low-resolution brain electromagnetic tomography.

The practice of active patient involvement in rare disease research using ICT: experiences and lessons from the RUDY JAPAN project.

Background: The role of patients in medical research is changing, as more emphasis is being placed on patient involvement, and patient reported outcomes are increasingly contributing to clinical decision-making. Information and communication technology provides new opportunities for patients to actively become involved in research. These trends are particularly noticeable in Europe and the US, but less obvious in Japan.

Effects of Nutrition Education Program for the Japan Diet on Serum LDL-Cholesterol Concentration in Patients with Dyslipidemia: A Randomized Controlled Trial.

Aim: The Japan Diet (JD) recommended by the Japan Atherosclerosis Society based on the traditional Japanese diet is presumably favorable for preventing atherosclerotic cardiovascular diseases, but few high-quality controlled clinical trials have examined its benefits as compared with other diets. We studied effects of nutrition education for JD intake as compared with partial JD (PJD) intake on serum lipids and inflammatory parameters in subjects with dyslipidemia.

Methods: A randomized parallel controlled clinical trial was conducted on outpatients with dyslipidemia.

Transcranial direct current stimulation of the posterior parietal cortex biases human hand choice.

Hand choices-deciding which hand to use to reach for targets-represent continuous, daily, unconscious decisions. The posterior parietal cortex (PPC) contralateral to the selected hand is activated during a hand-choice task, and disruption of left PPC activity with a single-pulse transcranial magnetic stimulation prior to the execution of the motion suppresses the choice to use the right hand but not vice versa. These findings imply the involvement of either bilateral or left PPC in hand choice.

A population-based cross-sectional study of the association between periodontitis and arterial stiffness among the older Japanese population.

Objective: To investigate the potential association between periodontitis and arterial stiffness among the older Japanese population.

Background: The prevalence of periodontitis is increasing in Japanese older adults. Arterial stiffness increases the risks of cardiovascular events and death, morbidity, and dementia.

Enhanced learning to improve letter knowledge in children with Down syndrome and severe intellectual disability: A case report.

Children with Down syndrome and severe intellectual disability have difficulties in learning a language. Enhanced learning procedure, including mora segmentation is beneficial to understand letter-sound correspondence in such children.