Quality of life and subjective symptom impact in Japanese patients with myotonic dystrophy type 1.

Background: Although functional impairment in patients with myotonic dystrophy is an important determinant of the quality of life (QoL), patients' subjective evaluation of their symptoms may also affect their QoL. The aim of this study was to investigate the association between subjective symptom impact and the QoL of patients with myotonic dystrophy, after controlling for functional impairment.

Methods: Eligible patients with myotonic dystrophy type 1 (DM1) were recruited from four hospitals in Japan.

Association between protein intake and changes in renal function among Japanese community-dwelling older people: The SONIC study.

Aim: The aim of this study was to clarify the association between dietary protein intake and decline in the estimated glomerular filtration rate (eGFR) among Japanese older adults.

Methods: We used the data of the Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) study, an ongoing narrow-age range cohort study: 69-71 years, 79-81 years and 89-91 years. The outcome variable, change in eGFR, was estimated from serum creatinine measured at the baseline and 3-year follow up, and the exposure variable, protein intake, was calculated using the brief-type self-administered diet history questionnaire at the baseline.

Gynecological aspects as a component of comprehensive geriatric assessment: A study of self-rated symptoms of pelvic organ prolapse among community-dwelling elderly women in Japan.

Objectives: Despite the reported 'male-female health-survival paradox', no components of the comprehensive geriatric assessment (CGA) routinely used in the field of geriatrics focus on female-specific symptoms. To investigate the impact of gynecological factors among elderly women, we noted the gynecological history and examined the association between self-rated symptoms of pelvic organ prolapse (POP) and CGA.

Study Design: This community-based, cross-sectional study in Japan included 164 community-dwelling women aged ≥75 years.

Justification of Sentencing Decisions: Development of a Ratio-Based Measure Tested on Child Neglect Cases.

Theoretically, people's justification of a sentencing decision involves a hybrid structure comprising retribution, incapacitation, general deterrence, and rehabilitation. In this study, a new ratio-type measure was developed to assess this structure and was tested to detect changes in the weighting of justification according to the content emphasized in a particular crime. Two child neglect scenarios were presented to participants, where they read either a severe-damage scenario (where a single mother's selfish neglect caused her son's death) or a moderate-damage scenario (where a single mother became apathetic due to economic deprivation and caused her child's debilitation).

National identity predicts public health support during a global pandemic.

Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g.

COVID-19 school and kindergarten closure relates to children's social relationships: a longitudinal study in Japan.

The COVID-19 pandemic has led children to experience school closures. Although increasing evidence suggests that such intense social quarantine influences children's social relationships with others, longitudinal studies are limited. Using longitudinal data collected during (T1) and after (T2) intensive school closure and home confinement, this study investigated the impacts of social quarantine on children's social relationships.

Visual discrimination accuracy does not differ between nasal inhalation and exhalation when stimuli are voluntarily aligned to breathing phase.

This study investigated the possible enhancement of visual discrimination accuracy by voluntarily adjusting the timing of stimulus presentation to a specific respiratory phase. Previous research has suggested that respiratory phases modulate perceptual and cognitive processing. For instance, a fearful face was identified faster when presented during nasal inhalation than during nasal exhalation, which could be related to changes in neural oscillatory activity synchronized with breathing in through one's nose.

Cognitive flexibility in 12-month-old preterm and term infants is associated with neurobehavioural development in 18-month-olds.

There is growing evidence that preterm children are at an increased risk of poor executive functioning, which underlies behavioural and attention problems. Previous studies have suggested that early cognitive flexibility is a possible predictor of later executive function; however, how it develops in infancy and relates to the later neurobehavioural outcomes is still unclear in the preterm population. Here, we conducted a longitudinal study to investigate oculomotor response shifting in 27 preterm and 25 term infants at 12 months and its relationship with general cognitive development and effortful control, which is a temperamental aspect closely associated with executive function, at 18 months.

COVID-19-Related Lifestyle Changes among Community-Dwelling Older Adult Day-Care Users: A Qualitative Study.

In Japan, the community-based comprehensive care system is an important initiative. The purpose of this study was to understand COVID-19-related lifestyle changes experienced by older adults who lived in communities and used day-care services. Using a qualitative inductive research method, semi-structured interviews were conducted with 13 older adults who used day-care services in Kyoto City, which assessed lifestyle changes before and after the spread of COVID-19 during March-April 2021.

Can Muscle Mass Be Maintained with A Simple Resistance Intervention in the Older People? A Cluster Randomized Controlled Trial in Thailand.

The aging population is rapidly increasing worldwide. Sarcopenia is a common and important health problem among older people. The prevalence of sarcopenia among older Thai adults is increasing.

Decoding peak emotional responses to music from computational acoustic and lyrical features.

Music can evoke strong emotions. Research has suggested that pleasurable chills (shivering) and tears (weeping) are peak emotional responses to music. The present study examines whether computational acoustic and lyrical features can decode chills and tears.

Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development.

Brain development is a highly orchestrated process requiring spatiotemporally regulated mitochondrial dynamics. Drp1, a key molecule in the mitochondrial fission machinery, undergoes various post-translational modifications including conjugation to the small ubiquitin-like modifier (SUMO). However, the functional significance of SUMOylation/deSUMOylation on Drp1 remains controversial.

Mild Cognitive Decline Is a Risk Factor for Scam Vulnerability in Older Adults.

Research on elderly financial exploitation has mostly focused on financial abuse that occurs in families and other types of trusted relationships. As such, little is known about financial frauds and scams perpetrated by strangers. Financial fraud and scam prevention activities for older adults must be promoted, for which the correlation between the psychological, social, and cognitive characteristics of their vulnerability needs to be determined.

Clinical course of the longest-lived man in the world: A case report.

Background And Objective: Supercentenarians, people who have reached 110 years of age, represent an ultimate model of human longevity. We have conducted research from both biomedical and psychosocial perspectives to clarify the factors that contribute to healthy longevity. The current study described the clinical course of the oldest lived man in the world.

The Intention to Conceal Does Not Always Affect Time Perception.

The display duration of stimuli is overestimated due to the increase in phasic arousal induced by the stimuli or high levels of background arousal. A previous study demonstrated that display duration of items (2 s) was overestimated when a participant attempted to conceal one of the items so as not to be detected in the concealed information test (CIT). As the time perception remained the same between the item to be concealed and the other items, the overestimation was thought to be due to the high level of background arousal under the conceal condition.

The impact of positive and negative testimony on children's attitudes toward others.

Children can identify who is benevolent or malevolent not only through first-hand experiences and observations but also from the testimony of others. In this study, we investigated whether 5- and 7-year-olds (N = 128) would form their attitudes toward others after hearing testimony about that person's past moral behavior and whether the valence of testimony would differently influence the children. In the positive condition, half of the participants gained information about three puppets: puppet A's prosocial behavior by their own first-hand observation, testimony about puppet B's past prosocial behavior, and testimony about puppet C's past neutral behavior.

Associations between anger and chronic primary pain: a systematic review and meta-analysis.

Objectives: Anger is a negative emotion characterized by antagonism toward someone or something, is rooted in an appraisal or attribution of wrongdoing, and is accompanied by an action tendency to undo the wrongdoing. Anger is prevalent in individuals with chronic pain, especially those with chronic primary pain. The associations between anger and pain-related outcomes (e.

[Decrease in activity and its related factors under COVID-19 crisis in community-dwelling older people].

Aim: To prevent the transmission of the novel coronavirus [COVID-19] and stop its spread, a state of emergency was declared from April to May 2020. People were encouraged to refrain from outings and reduce their contact with people. The purpose of this study was to examine the subjective changes in the amount of activity under COVID-19 crisis among the elderly and the factors related to this decrease in activity.

Effects of a Low-Salt and High-Potassium Diet on Arterial Stiffness and Left Ventricular Function in Indigenous Papuans.

Background A sodium-restricted diet represents a potential non-pharmacological strategy for improving blood pressure, arterial stiffness, and left ventricular (LV) diastolic function. We investigated age-related differences in LV structure and function and the relationship between LV function and central hemodynamics in an indigenous Papuan population, who maintain a traditional lifestyle, including a low-salt and high-potassium diet. Methods and Results We measured LV dimensions, transmitral blood flow, and mitral annular tissue velocities through echocardiography and Doppler imaging.

Enlargement of female pupils when perceiving something cute.

It is reported that women's pupils dilate when they see a baby; it is unclear if this pupillary response is caused by the perception of cuteness itself. Since many objects besides babies can be perceived as cute, we investigated whether the perception of cuteness, or the type of object observed, is related to pupil dilation. In the first experiment, female participants were requested to rate the subjective cuteness of greyscale pictures of objects such as animals and foods; their pupil sizes were measured.

Comparative radiographic analysis of three-dimensional innate mobility of the foot bones under axial loading of humans and African great apes.

The human foot is considered to be morphologically adapted for habitual bipedal locomotion. However, how the mobility and mechanical interaction of the human foot with the ground under a weight-bearing condition differ from those of African great apes is not well understood. We compared three-dimensional (3D) bone kinematics of cadaver feet under axial loading of humans and African great apes using a biplanar X-ray fluoroscopy system.

Water, Sanitation and Hygiene (WASH) in Japanese elementary schools: Current conditions and practices.

Background: Water, sanitation, and hygiene (WASH) is the foundation for preventing infectious diseases, as the current COVID-19 pandemic has shown. WASH is essential for school health, yet there have been very few papers published on WASH in Japanese schools. The objective of this review is to describe the current conditions and practices in Japanese elementary schools using an international framework for WASH in schools and identify implications for handwashing promotion in other areas.

The Moderating Effect of Attention-Deficit Hyperactivity Disorder Symptoms on the Relationship Between Procrastination and Internalizing Symptoms in the General Adult Population.

The symptoms of attention-deficit hyperactivity disorder (ADHD) are known to exacerbate the effect of cognitive-behavioral impairments on emotional burden. Although adults with ADHD frequently experience procrastination and internalizing symptoms such as depression and anxiety, few studies have examined whether the association between procrastination and internalizing symptoms differs by ADHD symptoms. This study aimed to examine the moderating effect of ADHD symptoms on the association between procrastination and internalizing symptoms.