3,136 results match your criteria: "Graduate School of Comprehensive Human Sciences[Affiliation]"
Brain Res
October 2024
Department of Information Technology and Human Factors, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba Japan. Electronic address:
Although the focal brain cooling technique is widely used to examine brain function, the effects of cortical temperature at various levels on sensory information processing and neural mechanisms remain underexplored. To elucidate the mechanisms of temperature modulation in somatosensory processing, this study aimed to examine how P1 and N1 deflections of somatosensory evoked potentials (SEPs) depend on cortical temperature and how excitatory and inhibitory inputs contribute to this temperature dependency. SEPs were generated through electrical stimulation of the contralateral forepaw in anesthetized rats.
View Article and Find Full Text PDFFree Radic Res
May 2024
Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
While cysteine (CysSH) is known to be exported into the extracellular space, its biological significance is not well understood. The present study examined the movement of extracellular CysSH using stable isotope-labeled cystine (CysSSCys), which is transported into cells and reduced to CysSH. Exposure of HepG2 cells to 100 µM stable isotope-labeled CysSSCys resulted in 70 µM labeled CysSH in cell medium 1 h after CysSSCys exposure.
View Article and Find Full Text PDFMol Biol Rep
May 2024
Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Marmara University, Istanbul, Turkey.
Background: The mitochondrial carrier homolog 2 (MTCH2) is a mitochondrial outer membrane protein regulating mitochondrial metabolism and functions in lipid homeostasis and apoptosis. Experimental data on the interaction of MTCH2 with viral proteins in virus-infected cells are very limited. Here, the interaction of MTCH2 with PA subunit of influenza A virus RdRp and its effects on viral replication was investigated.
View Article and Find Full Text PDFSupport Care Cancer
May 2024
Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, Kawasaki, Kanagawa, Japan.
Purpose: The challenges of fertility loss owing to cancer treatment persist long after treatment. However, psychosocial care for fertility among cancer survivors who have completed cancer treatment is insufficient. This systematic review examined psychosocial experiences related to the potential loss of fertility and unsuccessful pregnancy after treatment in cancer survivors of reproductive age to identify psychosocial care needs.
View Article and Find Full Text PDFMicroPubl Biol
April 2024
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Autotaxin, encoded by the gene, produces lysophosphatidic acid (LPA), which exerts numerous biological functions via its cognate receptors. null mutant mice die by embryonic day 9.5 owing to aberrant vascular development in the yolk sac, preventing analysis after that period.
View Article and Find Full Text PDFJMA J
April 2024
Department of Health Services Research, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Introduction: The coronavirus disease 2019 (COVID-19) pandemic may have led to an increase in home deaths due to hospital bed shortage and hospital visitation restrictions. This study aimed to examine changes in the proportion of home deaths before and after the COVID-19 pandemic and identify associated factors.
Methods: We used publicly available nationwide data to describe the proportion of home deaths among total deaths from 2015 to 2021.
Patients with ulcerative colitis sometimes need a total colectomy with ileal pouch-anal anastomosis due to medically refractory disease or colitis-associated neoplasia. Up to 50% of patients with ulcerative colitis postoperatively develop pouchitis and the rate of chronic inflammatory pouch conditions requiring pouch excision or diverting ileostomy is reported to be 10%. In order to diagnose and monitor pouchitis, pouchoscopy is essential to assess endoscopic inflammatory findings of the J pouch and to survey neoplasia development, particularly in the remnant distal rectum.
View Article and Find Full Text PDFJ Phys Ther Sci
May 2024
Program in Disability Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba: 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8573 Japan.
[Purpose] This study aimed to assess whether the effects of training in fine motor skills, such as improving the accuracy of acupuncture depth, persisted after the training was completed. [Participants and Methods] Fifteen students (age, 28.0 ± 8.
View Article and Find Full Text PDFJ Control Release
June 2024
Department of Materials Science, Faculty of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8573, Japan; Master's School of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki 305-8573, Japan; Center for Research in Radiation, Isotope and Earth System Sciences (CRiES), University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki 305-8573, Japan; Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku Tokyo 113-0033, Japan; High-value Biomaterials Research and Commercialization Center (HBRCC), National Taipei University of Technology, Taipei 10608, Taiwan. Electronic address:
Non-alcoholic steatohepatitis (NASH), now known as metabolic dysfunction-associated steatohepatitis (MASH), involves oxidative stress caused by the overproduction of reactive oxygen species (ROS). Small-molecule antioxidants have not been approved for antioxidant chemotherapy because of severe adverse effects that collapse redox homeostasis, even in healthy tissues. To overcome these disadvantages, we have been developing poly(ethylene glycol)-block-poly(cysteine) (PEG-block-PCys)-based self-assembling polymer nanoparticles (Nanoes), releasing Cys after in vivo degradation by endogenous enzymes, to obtain antioxidant effects without adverse effects.
View Article and Find Full Text PDFInt J Mol Sci
April 2024
Master's and Doctoral Programs in Biology, Institute of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Ibaraki, Japan.
Brain aging causes a wide variety of changes at the molecular and cellular levels, leading to the decline of cognitive functions and increased vulnerability to neurodegenerative disorders. The research aimed at understanding the aging of the brain has made much progress in recent decades. Technological innovations such as single-cell RNA-sequencing (scRNA-seq), proteomic analyses, and spatial transcriptomic analyses have facilitated the research on the dynamic changes occurring within neurons, glia, and other cells along with their impacts on intercellular communication during aging.
View Article and Find Full Text PDFVision (Basel)
April 2024
Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8574, Ibaraki, Japan.
Visual motion information plays an important role in the control of movements in sports. Skilled ball players are thought to acquire accurate visual information by using an effective visual search strategy with eye and head movements. However, differences in catching ability and gaze movements due to sports experience and expertise have not been clarified.
View Article and Find Full Text PDFJ Immunol
June 2024
Department of Immunology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Sci Rep
April 2024
Institute of Health and Sport Sciences, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8574, Japan.
Allergol Int
October 2024
Department of Pediatrics, University of Tsukuba Hospital, Ibaraki, Japan; Department of Child Health, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Background: Intestinal bacteria may play a role in the development of food allergies. This study aimed to analyze and compare the gut microbiota of food-allergic children with that of healthy children of the same age.
Methods: Stool samples were collected from one-and-a-half-year-old food-allergic (FA group, n = 29) and healthy controls (HC group, n = 19).
J Clin Med
February 2024
Department of Rehabilitation Medicine, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
This study investigated the association between obesity and short-term patient-reported outcomes after total knee arthroplasty (TKA). The primary outcomes were the Western Ontario and McMaster Universities Osteoarthritis Index's (WOMAC) pain and function scores. Data were collected preoperatively and 2 and 4 weeks after surgery.
View Article and Find Full Text PDFJ Perioper Pract
April 2024
Department of Oral and Maxillofacial Surgery, Ibaraki Prefectural Central Hospital, Kasama, Japan.
Zoolog Sci
February 2024
Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan,
The past few decades have witnessed increasing research clarifying the role of endocrine signaling in the regulation of aging in both vertebrates and invertebrates. Studies using the model organism fruit fly have largely advanced our understanding of evolutionarily conserved mechanisms in the endocrinology of aging and anti-aging. Mutations in single genes involved in endocrine signaling modify lifespan, as do alterations of endocrine signaling in a tissue- or cell-specific manner, highlighting a central role of endocrine signaling in coordinating the crosstalk between tissues and cells to determine the pace of aging.
View Article and Find Full Text PDFNihon Ronen Igakkai Zasshi
April 2024
Graduate School of Comprehensive Human Sciences, University of Tsukuba.
Purpose: This study investigated the factors associated with oral frailty among community-dwelling older adults. In particular, we compared the factors between individuals in the young-old and old-old groups and clarified the differences between the two groups.
Methods: We measured the basic attributes, body composition, grip strength, gait function, oral function, cognitive function, and daily living function using the Kihon checklist in older people living independently in T City, Aichi Prefecture.
Prev Med Rep
May 2024
Department of Health Services Research, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan.
Objectives: This study investigated the relationship between health checkups, cervical cancer screenings, and breast cancer screenings (collectively referred to as wellness examinations) of wives and health checkups of their husbands. We aimed to develop strategies to encourage wellness examinations among married individuals in Japan.
Methods: This study used the 2019 Comprehensive Survey of Living Conditions, focusing on married couples aged 40-64.
Open Biol
April 2024
Laboratory Animal Resource Center in Trans-Border Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Functional regions that regulate biological phenomena are interspersed throughout eukaryotic genomes. The most definitive approach for identifying such regions is to confirm the phenotype of cells or organisms in which specific regions have been mutated or removed from the genome. This approach is invaluable for the functional analysis of genes with a defined functional element, the protein-coding sequence.
View Article and Find Full Text PDFMicrob Pathog
May 2024
Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address:
Enterotoxigenic Escherichia coli (ETEC) is one of the main causes of diarrhea in children and travelers in low-income regions. The virulence of ETEC is attributed to its heat-labile and heat-stable enterotoxins, as well as its colonization factors (CFs). CFs are essential for ETEC adherence to the intestinal epithelium.
View Article and Find Full Text PDFJ Sports Sci
March 2024
Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan.
In high jump, the thigh and shank rotations mainly induce the effective energy for height () by directly or indirectly (via joint work) converting horizontal-kinetic energy. Meanwhile, inter-individual differences in may not only be explained by large contributors. Here we show that the components due to relatively small contributor segments share variance with total while those due to the two largest contributor segments do not, by analyzing high jump of 15 male jumpers (personal best: 1.
View Article and Find Full Text PDFSleep Sci
March 2024
Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Healthcare (Basel)
March 2024
Department of Health Services Research, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Ibaraki, Japan.
The COVID-19 pandemic highlighted the need for advance care planning (ACP) as a way to help mitigate the various care concerns that accompanied the healthcare crisis. However, unique obstacles to typical ACP practice necessitated the need for guidance and innovation to help facilitate these vital conversations. The aim of this systematic review was to identify the various ACP barriers and facilitators that arose during the pandemic and determine how ACP practice was affected across different contexts and among different populations.
View Article and Find Full Text PDFJ Endourol
August 2024
Department of Urology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.