[Effect of the proteasome inhibitor MG-132 on hyperoxic lung injury and its mechanism in rats].

Objective: To observe the effects of proteasome inhibitor MG-132 on hyperoxic lung injury in rats and explore the mechanism.

Methods: Thirty SD rats were randomly divided into 3 groups, namely the normoxic group, hyperoxic group, and hyperoxic with MG-132 treatment group, and rat models of hyperoxic exposure-induced lung injury were established in the latter two groups. After pathological grading of the lung injury under optical microscope and determination of the wet/dry weight ratio of the lung tissue, the expressions of ubiquitin protein and nuclear factor-kappaB (NF-kappaB) p56 and the activity of proteasome 20S and myeloperoxidase (MPO) were detected.