Exposure sources, amounts and time course of gluten ingestion and excretion in patients with coeliac disease on a gluten-free diet.

Background: A major deficit in understanding and improving treatment in coeliac disease (CD) is the lack of empiric data on real world gluten exposure.

Aims: To estimate gluten exposure on a gluten-free diet (GFD) using immunoassays for gluten immunogenic peptides (GIP) and to examine relationships among GIP detection, symptoms and suspected gluten exposures METHODS: Adults with biopsy-confirmed CD on a GFD for 24 months were recruited from a population-based inception cohort. Participants kept a diary and collected urine samples for 10 days and stools on days 4-10.

Development of the Dietitian Integrated Evaluation Tool for Gluten-free Diets (DIET-GFD).

Objectives: Celiac disease (CD) treatment involves a gluten-free diet (GFD). There is no standardized tool for dietitians to objectively grade GFD adherence. This study aimed to develop a standardized tool for dietitians to evaluate and communicate GFD adherence.

Is it gluten-free? Relationship between self-reported gluten-free diet adherence and knowledge of gluten content of foods.

Objective: To assess the relationship between self-reported adherence to a gluten-free diet (GFD) and the ability to determine correctly the appropriateness of particular foods in a GFD.

Methods: Persons with celiac disease were recruited through clinics and support groups. Participants completed a questionnaire with items related to GFD information sources, gluten content of 17 common foods (food to avoid, food allowed, and food to question), GFD adherence, and demographic characteristics.

Factors associated with initiation of medical advanced cardiac life support after out-of-hospital cardiac arrest.

Background: Termination of resuscitation rule permits to stop futile resuscitative efforts by paramedics. In a different setting, the decision to withhold resuscitation by emergency physician could be based on different factors. We aimed to identify the factors associated with the initiation of a medical ACLS in out-of-hospital cardiac arrest patients.

Infectious endocarditis caused by Helcococcus kunzii in a vascular patient: a case report and literature review.

Background: Helcococcus kunzii is a facultative anaerobic bacterium that was first described by Collins et al. in 1993, and was initially considered as a commensal of the human skin, in particular of lower extremities. Human infections caused by H.

Living gluten-free: adherence, knowledge, lifestyle adaptations and feelings towards a gluten-free diet.

Background: A gluten-free diet (GFD) requires tremendous dedication, involving substantive changes to diet and lifestyle that may have a significant impact upon quality of life. The present study aimed io assess dietary adherence, knowledge of a GFD, and the emotional and lifestyle impact of a GFD.

Methods: Community dwelling adults following a GFD completed a questionnaire with items related to reasons for avoiding gluten, diagnostic testing, GFD adherence, knowledge and sources of information about a GFD, the Work and Social Adjustment Scale, and the effect of a GFD diet on lifestyle, feelings and behaviours.

Osteopontin localizes to the nucleus of 293 cells and associates with polo-like kinase-1.

Osteopontin (OPN) is a secreted phosphoprotein involved in cellular proliferation and associated with tumor progression. Although an intracellular form of OPN has been described, its function remains unknown. In this study, a novel nuclear location for intracellular OPN and a correlation with cell division were demonstrated.

Dermal exposure to strychnine.

A non-fatal case of strychnine poisoning through dermal exposure is described. About 24 h after cleaning up a strychnine spill, a 50-year-old woman presented to the emergency department with classical signs of strychnine poisoning, consisting of marked pain in the muscles of her lower limbs, dermal sensitivity, and stiffness in her jaw. Her treatment was intravenous fluid replacement and alkalinization in anticipation of potential renal failure due to rhabdomyolysis.

A randomized trial of two levels of iron supplementation and developmental outcome in low birth weight infants.

Objectives: To investigate the effect of increased iron intakes on hematologic status and cognition in low birth weight infants.

Study Design: We randomly assigned 58 infants to receive formula with 13.4 mg iron/L (normal iron) or 20.

Successful intrauterine pregnancy after endometrial ablation.

The frequency of pregnancy after endometrial ablation is reported in the literature to be 0.7%, with a variety of complications and adverse outcomes for the fetus. A 30-year-old woman underwent rollerball endometrial ablation for menometrorrhagia.

Serial change in echocardiographic parameters and cardiac failure in end-stage renal disease.

Echocardiographic abnormalities are the rule in patients starting dialysis therapy and are associated with the development of cardiac failure and death. It is unknown, however, whether regression of these abnormalities is associated with an improvement in prognosis. As part of a prospective cohort study with mean follow-up of 41 mo, 227 patients had echocardiography at inception and after 1 yr of dialysis therapy.

Randomized comparison of oral misoprostol and oxytocin for labor induction in term prelabor membrane rupture.

Objectives: To compare labor induction intervals between oral misoprostol and intravenous oxytocin in women who present at term with premature rupture of membranes.

Methods: One hundred eight women were randomly assigned to misoprostol 50 microg orally every 4 hours as needed or intravenous oxytocin. The primary outcome measure was time from induction to vaginal delivery.

Antihypertensive effect of low ethanol intake in spontaneously hypertensive rats.

Light to moderate drinking in humans lowers the risk of coronary heart disease and may lower blood pressure. We examined the effect of chronic low daily alcohol consumption on blood pressure, platelet cytosolic free calcium [Ca2+]i, tissue aldehyde conjugates and renal vascular changes in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). We also examined the effects of the same weekly amount of alcohol consumption over a one day period each week simulating weekend drinking in humans.

Factor V deficiency and menstruation: a gynecologic challenge.

Background: Menorrhagia is a well-known complication of factor V deficiency.

Case: A 13-year-old girl with factor V deficiency presented with acute hemorrhage on day 4 of menses. Laboratory assessment revealed a hemoglobin of 36 g/L.

Oral administration of misoprostol for labor induction: a randomized controlled trial.

Objective: To evaluate the effectiveness, safety, and gastrointestinal tolerance of misoprostol taken orally for induction of labor, against our established protocol, with the interval from induction to vaginal birth as the primary outcome measure.

Methods: Two hundred seventy-five women who presented with indication for induction of labor were assigned randomly to receive either 50 micrograms of misoprostol orally every 4 hours as needed or treatment according to our established protocol (physician-chosen combinations of intracervical or vaginal prostaglandins every 4-6 hours, artificial rupture of membranes, and oxytocin infusion). Sample size was calculated with a two-tailed alpha = .

Creutzfeld-Jakob disease: the Grace General Hospital experience.

After some patients were exposed to a blood product from a donor with Creutzfeld-Jakob disease, Winnipeg hospitals had to decide whether to inform them of the possibly minuscule health risk. The Salvation Army Grace Hospital decided to inform its patients, citing their fundamental right to facts regarding their own health; their need to make a responsible, informed decision regarding donation of their own blood or organs; and the need to maintain the trust and confidence of the public in the wake of the Krever inquiry.

Vaginal misoprostol for induction of labor: a randomized controlled trial.

Objective: To evaluate the effectiveness and safety of the vaginal application of misoprostol for induction of labor at term, with the interval duration from labor induction to vaginal birth as the primary outcome measure.

Methods: Two hundred twenty-two women with indications for induction of labor at term were randomized to receive either misoprostol 50 micrograms per vagina every 4 hours as needed or our standard approach (physician-chosen combinations of intracervical or vaginal dinoprostone every 6 hours, artificial rupture of membranes, and oxytocin infusion).

Results: Mean (+/-standard deviation) time to vaginal delivery was 753 +/- 588 minutes for misoprostol versus 941 +/- 506 minutes for the physician-chosen combination (P = .

Outcome and risk factors for left ventricular disorders in chronic uraemia.

Background: Left ventricular disease occurs frequently in dialysis patients. It may be manifest as concentric LV hypertrophy, LV dilatation with or without LV hypertrophy, or systolic dysfunction. Little is known concerning the clinical outcome and risk factors for these disorders.

Outcome and risk factors of ischemic heart disease in chronic uremia.

To determine the prognosis and risk factors for ischemic heart disease in chronic uremia, a cohort of 432 dialysis patients were followed prospectively from start of dialysis therapy until death or renal transplantation. Baseline demographic, clinical and echocardiographic data were obtained. After the initiation of dialysis laboratory data were collected at monthly intervals, and clinical and echocardiographic data at yearly intervals.

Acanthamoeba keratitis in a soft-contact-lens wearer.

Acanthamoeba keratitis is an uncommon but potentially devastating complication of contact lens wear. We present a case of Acanthamoeba keratitis in a soft-contact-lens wearer successfully treated with long-term medical therapy and penetrating keratoplasty. To our knowledge this is the first case of Acanthamoeba keratitis diagnosed in Canada.

Cystic mucinous tumours of the mesentery and retroperitoneum: report of three cases.

A mucinous cystadenoma of the mesentery and two borderline mucinous cystadenocarcinomas of the mesentery and retroperitoneum are reported. The patients were females, aged 38, 47 and 58 years. The cysts showed identical features to those commonly seen in the appendix and ovary.

Pain and personality profiles in burning mouth syndrome.

The McGill Pain Questionnaire (MPQ) and the Minnesota Multiphasic Personality Inventory (MMPI) were administered to 72 subjects with burning mouth syndrome (BMS) who were also requested to match the levels of their clinical pain to line lengths on a visual analogue scale (VAS) and to experimentally induced warm and painful thermal stimuli. The responses of 102 toothache pain subjects and 43 asymptomatic age- and sex-matched control subjects were used to compare the responses of the BMS subjects on the MPQ and MMPI, respectively. The results indicated that BMS pain is quantitatively similar to, but qualitatively different from, toothache pain, that self-reports of BMS pain appear to be valid, that when compared to the asymptomatic control subjects, BMS subjects show elevations in certain personality characteristics which are similar to those seen in other chronic pain patients, and that these personality disturbances tend to increase with increased pain.