633 results match your criteria: "Gr.T. Popa University of Medicine and Pharmacy[Affiliation]"

Fibrillinopathies have different phenotypic expression: Marfan-like skeleton features, MLSF; mitral valve prolapse syndrome, MVPS; MASS phenotype, M = mitral valve prolapse, MVP, A = aortic root dilation, S = skeletal features, and the second S = (cutaneous) striae; Marfan Syndrome, MS. The study had the following main objectives: the correlation between disc displacement, DD (a major sign for temporomandibular joint dysfunction, TMDs) on magnetic resonance imaging, MRI, and aortic Z score (a major sign for aortic root dilation) on echocardiography; the predictive value of DD towards aortic Z score. DD had 2 types of severity: DD with reduction (the mild type, DDwR), and DD without reduction (the severe type, DDwoR).

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: Less often employed as a rinsing solution for controlling oral biofilms, NaOCL was used in oral rinses at various concentrations in steps 1 and 4 of periodontal therapy. The aim of this study was to quantitatively evaluate the biofilm-disruptive properties of a 0.2% NaOCl solution in standardized oral rinses using dedicated plaque-disclosing agents and 3D scanning methods in patients undergoing the regular Guided Biofilm Therapy protocol.

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  • Surgery is no longer the primary treatment for prolactinomas according to current guidelines, yet it's still important for certain cases, particularly those with complications or resistant to medication.
  • The study analyzed 12 patients who underwent endoscopic transsphenoidal surgery for prolactinomas between 2013 and 2022, focusing on surgical indications, outcomes, and complications.
  • Results showed that most patients had prior treatment with dopamine agonists and experienced complications like transient diabetes insipidus, with surgery effectively recommended for those with neurological symptoms or treatment failures.
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  • - A 32-year-old male with a 7-year history of Graves disease experienced multiple recurrences requiring anti-thyroid medication, leading to fluctuating thyroid hormone levels and a period of remission before developing hyperthyroid symptoms again.
  • - Diagnostic tests revealed elevated TRAb levels and a new thyroid nodule on ultrasound, classified as EU-TIRADS score 4, which led to surgery.
  • - Post-surgery histopathology confirmed the nodule was a papillary microcarcinoma of 1 mm, associated with Hashimoto thyroiditis, and the patient's recovery was complicated by parathyreoprive tetany.
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Electrophysiological studies of the larynx expose the mechanisms by which voice production is controlled. Previous studies have revealed certain phenomena during laryngeal oscillations that suggest a complex control mechanism. Starting from the principle of agonist-antagonist muscular pairing, the aim of this study was to gain a deeper insight into the function of the cricothyroid (CT) and thyroarytenoid (TA) muscles, both central to voice production.

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The Relationship between Job Strain and Ischemic Heart Disease Mediated by Endothelial Dysfunction Markers and Imaging.

Medicina (Kaunas)

June 2024

2nd Morpho-Functional Department, Biophysics and Medical Physics, "Gr.T.Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.

: Job strain is a psychological, physical, and behavioral stress that occurs at the workplace. Job strain is associated with more than double the normal risk of coronary artery disease (CAD). The main aim of this study was to determine the association between job strain and the following parameters: high-sensitivity C-reactive protein (hs-CRP), the albumin urine excretion rate (AUER), and secondary-level testing.

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Xanthan-Polyurethane Conjugates: An Efficient Approach for Drug Delivery.

Polymers (Basel)

June 2024

Department of Plastic Surgery and Reconstructive Microsurgery, "Sf. Spiridon" Emergency County Hospital Iasi, "Gr. T. Popa" University of Medicine and Pharmacy Iasi, Bulevardul Independentei No. 1, 700115 Iasi, Romania.

The antifungal agent, ketoconazole, and the anti-inflammatory drug, piroxicam, were incorporated into matrices of xanthan or oleic acid-esterified xanthan (Xn) and polyurethane (PU), to develop topical drug delivery systems. Compared to matrices without bioactive compounds, which only showed a nominal compressive stress of 32.18 kPa (sample xanthan-polyurethane) at a strain of 71.

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Montelukast Influence on Lung in Experimental Diabetes.

Medicina (Kaunas)

April 2024

Department of Pharmacology, "Gr T Popa" University of Medicine and Pharmacy, Universitatii 16, 700115 Iasi, Romania.

: The influence of montelukast (MK), an antagonist of cysLT1 leukotriene receptors, on lung lesions caused by experimental diabetes was studied. : The study was conducted on four groups of six adult male Wistar rats. Diabetes was produced by administration of streptozotocin 65 mg/kg ip.

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Cervical cancer continues to be a public health concern, as it remains the second most common cancer despite screening programs. It is the third most common cause of cancer-related death for women, and the majority of cases happen in developing nations. The standard treatment for locally advanced cervical cancer involves the use of external beam radiation therapy, along with concurrent chemotherapy, followed by an image-guided adaptive brachytherapy (IGABT) boost.

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Background: Palliative care is a challenging specialty, especially when it comes to caring for children with serious life-limiting conditions and supporting their families. Workers face significant challenges and experience major impacts on their wellbeing. We conducted a qualitative study to understand the sources of stress in the palliative care team, their work expectations, and how they can cope with the demands.

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Unlabelled: Cytomegalovirus (CMV), a DNA virus that belongs to the family, infects 40-100% of people. Primary/non-primary CMV infection during pregnancy could cause fetal disabilities. After primary infection, CMV causes a latent infection and resides in cells of the myeloid compartment (CD34, monocytes).

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Investigations on binding strength differences of non-covalent protein complex components were performed by mass spectrometry. T4 fibritin foldon (T4Ff) is a well-studied miniprotein, which together with its biotinylated version served as model system to represent a compactly folded protein to which an Intrinsically Disordered Region (IDR) was attached. The apparent enthalpies of the gas phase dissociation reactions of the homo-trimeric foldon F-F-F and of the homo-trimeric triply biotinylated foldon bF-bF-bF have been determined to be rather similar (3.

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Heat Treatment's Vital Role: Elevating Orthodontic Mini-Implants for Superior Performance and Longevity-Pilot Study.

Dent J (Basel)

April 2024

Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, "Gr. T. Popa" University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania.

Unlabelled: Orthodontic mini-implants are devices used for anchorage in various orthodontic treatments. We conducted a pilot study which aimed to observe preliminary trends regarding the impact of heat treatment on the elastic modulus of Ti6Al4V alloy and stainless steel 316L mini-implants. The initial phase involved testing the impact of heat treatment on the mechanical properties of Ti6Al4V alloy and stainless steel 316L mini-implants.

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Article Synopsis
  • - Breast cancer is the leading cause of cancer death among women and is increasingly diagnosed, especially in developing countries where women often present with advanced disease, making surgery difficult.
  • - Poor overall survival is linked to factors like short disease-free intervals and liver metastasis, highlighting the importance of timely and effective treatment strategies.
  • - New approaches such as neoadjuvant chemotherapy and targeted therapies are changing the role of surgery from just palliative care to potentially curative, while advancements in reconstructive techniques are enhancing patients' quality of life.
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Takayasu's Arteritis: A Special Case Report and Review of the Literature.

Medicina (Kaunas)

March 2024

1st Surgery Department-Cardiac Surgery, "Gr. T. Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.

: Takayasu's arteritis is a rare type of vasculitis with severe complications like stroke, ischemic heart disease, pulmonary hypertension, secondary hypertension, and aneurysms. Diagnosis is achieved using clinical and angiographic criteria. Treatment is medical and surgical, but unfortunately, the outcome is limited.

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Wolf-Parkinson-White (WPW) syndrome is a disorder characterized by the presence of at least one accessory pathway (AP) that can predispose people to atrial/ventricular tachyarrhythmias and even sudden cardiac death. It is the second most common cause of paroxysmal supraventricular tachycardia in most parts of the world, affecting about 0.1-0.

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Statins are a class of medications primarily used in adults to lower cholesterol levels and reduce the risk of cardiovascular events. However, the use of statins in children is generally limited and carefully considered despite the well-documented anti-inflammatory, anti-angiogenic, and pro-apoptotic effects, as well as their effect on cell signaling pathways. These multifaceted effects, known as pleiotropic effects, encompass enhancements in endothelial function, a significant reduction in oxidative stress, the stabilization of atherosclerotic plaques, immunomodulation, the inhibition of vascular smooth muscle proliferation, an influence on bone metabolism, anti-inflammatory properties, antithrombotic effects, and a diminished risk of dementia.

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Atypical polypoid adenomyoma (APAM) is a rare polypoid benign tumor of the uterus that causes irregular vaginal bleeding in women of reproductive age. It has the potential for malignant transformation, but it does not metastasize. APAM may coexist with endometrial hyperplasia and adenocarcinoma, usually leading to misdiagnosis.

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Introduction: Neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and pallets-to-lymphocyte ratio (PLR) are currently validated as cheap and accessible biomarkers in different types of solid tumors, including head and neck cancers (HNC).

The Purpose Of The Study: To evaluate the possible purposes and biomarker value of NLR, PLR, and MLR recorded pre-treatment (radiotherapy/chemotherapy) in HNC.

Materials And Methods: From 190 patients with HNC included in the oncology records in the oncology outpatient clinic of the Craiova County Emergency Hospital (from January 2002 to December 2022), 39 cases met the inclusion criteria (squamous cell carcinoma and the possibility to calculate the pre-treatment (chemotherapy/radiotherapy) value of NLR, PLR, and MLR.

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A new approach to explore the correlation between declarative memory and anxiety in animal models of schizophrenia and microplastic pollution.

Behav Brain Res

February 2024

Doctoral School of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University of Iasi, Carol I Bd., 20A, 700505 Iasi, Romania; Academy of Romanian Scientists, Splaiul Independentei no. 54, sector 5, 050094 Bucharest, Romania; Center of Biomedical Research, Romanian Academy, Carol I Bd., No 8, 010071 Iasi, Romania.

The discovery of new detrimental effects associated with microplastic pollution is ever-growing and reaching alarming rates worldwide, as it is linked to numerous disorders such as lung diseases, gastrointestinal problems, and cancer. However, a less explored issue is their impact on mental health, more precisely schizophrenia, even though several studies have shown the presence of microplastics in air, water, soil, and even food, thus making them a significant part of our daily dietary intake. It is also well known that declarative memory and anxiety levels are impaired in schizophrenia.

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Non-alcoholic fatty liver disease (NAFLD) has gained attention in the last few years due to its increasing prevalence worldwide becoming a global epidemic. The increasing incidence of NAFLD and the concurrent increase in the number of hepatocellular carcinoma (HCC) cases at a global level is a matter of concern. HCC has several risk factors, of which NAFLD and its associated metabolic disturbances-type 2 diabetes mellitus, obesity, and dyslipidemia-are of great interest due to their accelerating rise in incidence worldwide.

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Spinal disorders cover a broad spectrum of pathologies and are among the most prevalent medical conditions. The management of these health issues was noted to be increasingly based on surgical interventions. Spinal fixation devices are often employed to improve surgery outcomes, increasing spinal stability, restoring structural integrity, and ensuring functionality.

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In terms of production technology, metal-ceramic systems for dental restorations comply with a concrete algorithm, the efficiency of which is always dependent on the applications for which they are intended. The first stage involves obtaining metal support, followed by firing the ceramic on the surface of the metal to meet the list of functional and aesthetic requirements of a future restoration. The compatibility of the two materials-the metal component and the ceramic component-must be ensured in several respects: chemical compatibility, thermo-chemical compatibility, and mechanical compatibility.

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Evaluation of sexual dimorphism is a crucial concern for anthropologists, forensic scientists, and archaeologists. Teeth have been used as an alternative tool to determine sex in forensic anthropology. However, it is necessary to use data specific to a particular population, as different populations exhibit varying degrees of sexual dimorphism.

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Leukotrienes are important icosanoids group involved in a lot of normal and pathological states. Montelukast (MK) is a selective cysteinyl leukotriene receptor (Cys LT1) antagonist. Purpose.

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