2,534 results match your criteria: "Govt. Medical College &Rajindra Hospital[Affiliation]"
Heliyon
November 2024
Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, Kerala, India.
Early-onset colorectal cancer (EOCRC), recognized as a distinct subgroup with an increased incidence over the past two decades, characterized by its aggressive nature and potentially unique molecular factors that differentiate it from traditional colorectal cancer (CRC). In this study, we investigated differentially expressed genes in a young-CRC patient using paired-end mRNA-sequencing. Validation of target genes through qRT-PCR highlighted a significant increase in SERPINA3 levels in EOCRC, representing a novel finding.
View Article and Find Full Text PDFExplore (NY)
November 2024
Dept. of Community Medicine, D. N. De Homoeopathic Medical College and Hospital, Govt. of West Bengal, 12, Gobinda Khatick Road, Tangra, Kolkata 700046, West Bengal, India. Electronic address:
Context: Nocturnal enuresis (NE) is a very common problem in childhood. The prevalence rate varies from 3.5% to 56.
View Article and Find Full Text PDFSci Rep
November 2024
Faculty of Production and Power Engineering, University of Agriculture in Krakow, Balicka 116B, 30-149, Krakow, Poland.
Indian J Psychol Med
October 2024
Dept. of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India.
Indian J Psychol Med
June 2024
Dept. of Psychiatry, Jalpaiguri Govt. Medical College, Jalpaiguri, West Bengal, India.
Indian J Otolaryngol Head Neck Surg
December 2024
Department of Surgical Oncology, Madras Medical College, Rajiv Gandhi Govt. General Hospital, Chennai, Tamil Nadu India.
Marginal mandibulectomy is indicated for oral cavity squamous cell carcinomas that involve floor of mouth, abut or minimally erode the mandible without gross invasion. Successful outcomes after Marginal mandibulectomy is predicated on accurate patient selection and appropriate adjuvant treatment based on specific host and tumor characteristics. To study the onclogical outcomes in terms of loco-regional recurrence free survival and disease specific survival of marginal mandibulectomy done for oral squamous cell carcinomas.
View Article and Find Full Text PDFWorld Neurosurg
December 2024
Department of Neurosurgery, Neurosurgery Clinic, Birjung, Nepal.
Pain Manag
September 2024
Department of Clinical Development & Medical Affairs, Hetero Labs Limited, Hyderabad, India.
Aim: Polmacoxib, a new COX-2 inhibitor with carbonic anhydrase (CA) inhibitory action, is expected to help minimize the adverse effects associated with other NSAIDs, like GI (gastrointestinal) and CV (cardiovascular) system- related issues. The comparative efficacy and safety of polmacoxib 2 mg (manufactured by Hetero Labs Limited) versus celecoxib 200 mg (manufactured by Hetero Labs Limited) were assessed in this randomized, double-anonymous, clinical study in Indian adult patients diagnosed with idiopathic osteoarthritis (OA) of the.
Patients & Methodology: 18 years and older patients of either sex, clinically and radiographically diagnosed idiopathic knee or hip OA were randomized to receive either polmacoxib or celecoxib in a 1:1 ratio.
ChemMedChem
November 2024
Department of Zoology, Uluberia College, University of Calcutta, Uluberia, Howrah, 711315, India.
Here, we present a pleiotropic nanomedicine-a smart, functionalized redox buffering nanoparticle-that may be used to treat hematological diseases, associated splenic hyperplasia, and issues related to restricted erythropoiesis. With a diameter of 5-7 nm, the spherical nanomaterial is made of manganese oxide and citrate. Here, we have produced the novel nanomaterial and, using cutting-edge electron microscopic and spectroscopic techniques, extensively assessed its redox buffering potential in vitro with its structural integrity.
View Article and Find Full Text PDFSci Rep
November 2024
Principal, Govt Nursing College, Lady Reading Hospital, Peshawar, Pakistan.
The escalating challenge of antimicrobial resistance necessitates the development of novel antibacterial agents. In this study, a series of five vanillin Schiff bases (SB-1 to SB-5) were synthesized from vanillin and various aromatic amines. The chemical structures of these compounds were characterized using Thin Layer Chromatography (TLC), Fourier Transform Infrared Spectroscopy (FT-IR), proton nuclear magnetic resonance ( -NMR), carbon-13 NMR ( -NMR), and mass spectrometry techniques.
View Article and Find Full Text PDFIran J Microbiol
October 2024
Department of Microbiology, Govt Medical College, Ernakulam, Kerala, India.
Background And Objectives: Coagulase-negative-Staphylococci (CoNS) are important etiological agent of bacteraemia in newborn babies. Methicillin resistant CoNS infections have only limited treatment options. The antimicrobial susceptibility pattern of Methicillin Resistant CoNS isolates from newborn blood cultures was studied with special reference to MICs of Vancomycin and Teicoplanin.
View Article and Find Full Text PDFInd Psychiatry J
August 2024
Department of Community Medicine, Shri M P Shah Govt Medical College, Jamnagar, Gujarat, India.
Background: Internet addiction (IA) and gaming disorder (IGD) are emerging public health concerns among youth. Sluggish cognitive tempo (SCT)/cognitive disengagement syndrome has been linked with risky online behaviors, but the literature on medical students is limited.
Aim: To determine associations between SCT, IA, and IGD in Indian medical undergraduates.
Front Psychiatry
October 2024
Department of Community Medicine, Government Medical College, Jammu, Jammu and Kashmir, India.
Mov Disord Clin Pract
November 2024
CSIR Institute of Genomics and Integrative Biology, New Delhi, India.
Background: Wilson's disease (WD) results from pathogenic ATP7B gene variations, causing copper accumulation mainly in the liver, brain, and kidneys.
Objectives: In India, despite studies on ATP7B variants, WD often goes undiagnosed, with the prevalence, carrier rate, and mutation spectrum remaining unknown.
Methods: A multicenter study examined genetic variations in WD among individuals of Indian origin via whole exome sequencing.
Drug Metab Pers Ther
November 2024
Department of Moalajat, School of Unani Medical Education & Research, Jamia Hamdard, New Delhi, India.
Objectives: Urinary tract infection (UTI) is one of the most frequent reasons for prescribing antibiotics. implicated in 75-90 % cases of UTI is becoming increasingly resistant to antibiotics. Finding alternative therapeutic agent for this infection is critical, for which herbal drugs may be an option.
View Article and Find Full Text PDFChem Biodivers
November 2024
Green Chemistry Laboratory, Organic Chemistry Division, Department of Chemistry, Aligarh Muslim University, Aligarh, 202002, India.
This study explores new anti-inflammatory agents by synthesizing pyrazoline-pyridine hybrids with N-butylsulfonated covalent organic framework (COF-SOH) as a recyclable catalyst, achieving excellent yields in just one minute. The protocol was successfully scaled up to a multi-gram scale, highlighting its robustness and efficiency, and it operates without the need for column chromatography. Among the synthesized hybrids, compound 5d, a pyrazoline-pyridine hybrid bearing an indole moiety, emerged as a potent anti-inflammatory and antioxidant agent.
View Article and Find Full Text PDFClin Rev Allergy Immunol
December 2024
Grenoble Alpes University, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, National Reference Center for Angioedema (CREAK), CHU Grenoble Alpes, TIMC, Grenoble, France.
Long-term prophylaxis (LTP) has been shown to reduce the frequency of hereditary angioedema (HAE) attacks; however, attacks occurring in patients receiving LTP have not been well characterized. The objective of this systematic review was to evaluate the proportion of type I/II HAE (HAE-C1INH) patients who experience attacks while receiving LTP, the characteristics of these attacks, and associated on-demand therapy use. A systematic search was conducted in PubMed to identify studies reporting LTP use with plasma-derived C1 inhibitor (pdC1INH), lanadelumab, berotralstat, androgens, or antifibrinolytics in patients with HAE-C1INH.
View Article and Find Full Text PDFPhotodermatol Photoimmunol Photomed
November 2024
Department of Nuclear Medicine, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India.
Background: Mitochondria could be an important target for ultraviolet radiation (UVR)-induced skin damage. Therefore, protecting mitochondria using mitochondria-targeted antioxidants may protect skin from UV-induced photodamage.
Methods: In the present study, UVR-induced skin damage model was developed by irradiating male Wistar rats with UVB at a dose of 120 mJ/cm, twice a week for a period of 5 weeks.
One Health
December 2024
Population, Policy and Practice Department, UCL Great Ormond Street Institute of Child Health, 30 Guildford Street, London WC1N 1EH, UK.
Background: Slum communities face health risks influenced by environmental, human, and animal health factors, particularly antimicrobial resistance (AMR). Tailored, community-driven solutions are needed to address these multifactorial health determinants. This study explores One Health challenges in urban slums using a Patient and Public Involvement (PPI) approach.
View Article and Find Full Text PDFChem Biodivers
November 2024
Department of Chemistry, Govt. Raza P.G. College, (M.J.P Rohil Khand University, Bareilly), Rampur, 244901, UP, India.
Herein, the synthesis, anti-cancer evaluation, and in silico studies of a series of 1,2,4-oxadiazole compounds (8-15) are disclosed. The synthesized molecules were tested in vitro for anti-cancer activity against MCF-7, MDA-MB-231, HeLa, Ishikawa cell lines and human embryonic kidney (HEK-293) cell lines. Among the synthesized compounds, 9 and 15 exhibited significant cytotoxicity, with IC values of 7.
View Article and Find Full Text PDFJ Infect Public Health
December 2024
Scientist-G & Director, ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
Background: In July 2021, the Alappuzha district in Kerala, India, reported an unexpected number of acute gastroenteritis (772) cases (Outbreak A). On October 10, 2021, a university in Wayanad, Kerala, reported 25 acute gastroenteritis cases (Outbreak B). We described both the outbreaks and determined the agent, source and risk factors.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
November 2024
Department of Chemistry, Veer Surendra Sai University of Technology, Burla, Sambalpur, Odisha, 768018, India.
The binding interactions between bovine serum albumin (BSA) and three pyridine derivatives, i.e., 2-(5-bromopyridin-3-yl) acetic acid (L1), 3-bromo-5-nitropyridine (L2) and 2-chloro-4-nitropyridine (L3), have been carried out using UV-Vis and fluorescence spectroscopic methods.
View Article and Find Full Text PDFJ Cutan Med Surg
October 2024
Division of Pediatric Dermatology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Rosacea is a chronic inflammatory skin condition that affects over 5% of individuals worldwide. Its clinical presentation is characterized by an array of features, including erythema, papules and pustules, phymatous changes, telangiectasia, and ocular manifestations. Specifically, the multifaceted manifestation of erythema varies widely in intensity and distribution.
View Article and Find Full Text PDFSci Rep
October 2024
Department of Physiology, Govt. Medical College, Ratlam, Madhya Pradesh, India.
Obesity is associated with dysfunctional electrocardiographic and cardiac autonomic parameters, which may lead to increased cardiovascular morbidity. Novel electrocardiographic repolarization markers such as Tpeak-Tend (Tpe) interval have not yet been deeply studied in obese patients. We aimed to investigate the association between ventricular repolarization parameters and heart rate variability (HRV) and how they are affected by changes occurring in the cardiac autonomic nervous system.
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