Synthesis, crystal structure, characterization and antimicrobial activities of ternary chiral mononuclear Schiff base copper(II) complexes.

[CuL(tmen)] is a sequence of four ternary mononuclear Schiff base copper(II) complexes that are derived from L-valine, suitable 5'-substituted-2'-hydroxyacetophenones (where the substituents are -Cl for L, -Me for L, -OMe for L, and -H for L), and tmen (where tmen-N,N,N',N' tetramethyl ethylenediamine). Without isolating the Schiff base ligand or producing any other intermediate products, all of the complexes were synthesised. These compounds were identified using elemental analysis, molar conductance, UV-Vis, FTIR, EPR, VSM-RT, and CD spectra.

Does knowledge impact adherence?: correlation between HIV-infected pregnant women's knowledge of WHO-recommended PMTCT guidelines and their adherence to the PMTCT program in India.

WHO's 2013 PMTCT guidelines recommended lifelong antiretroviral therapy (ART) for HIV-infected pregnant and breastfeeding women, exclusive breastfeeding (EBF), nevirapine prophylaxis (NVP) and early infant diagnosis (EID) for HIV-exposed-breastfed infants. We examined the association between knowledge and adherence to these guidelines among 550 HIV-infected pregnant women in Maharashtra, India. Knowledge of PMTCT guidelines was assessed using a structured-questionnaire during enrollment.

Interbreed variation of dairy cow milk in terms of specific proteome and lipidome for establishing criteria of milk selection.

Background: Ruminant milk is a very complex table food and naturally encrypted with different components possessing various health-promoting characteristics.

Aim: In the present study, we focused on breed-wise compositional difference in milk including various components and release of fatty acids and peptides during digestion.

Methods: First, milk samples were analysed using lactoscan LW milk analyser, MALDI-TOF and gas chromatography.

Evaluation of Gluma® and MI Varnish™ for In-Office Treatment of Dentinal Hypersensitivity: An Observational Study.

Introduction In their routine practice, dentists frequently encounter dentinal hypersensitivity, which is caused by the pulpal nerves' increased excitability due to fluid movement in the dentinal tubules. It is treated in-office using dentin desensitizers, which reduce hypersensitivity by obstructing the open tubules or desensitizing the free nerve endings present within the tubules. However, no substance or treatment plan has ever been proven to be the gold standard for the efficient treatment of dentinal hypersensitivity.

Undergraduate psychiatry CBME curriculum revision: The process and the way ahead.

Nationa Medical Commission (NMC) had recently undertook the revision of Undergraduate CBME curriculum. the Authors were involved in Psychiatry curriculum revision. In this paper, authors explain the process of revision, the rationale behind the changes made and make specific suggestions for the better implementation of the revised curriculum.

UTF1 Expression is Important for the Generation and Maintenance of Human iPSCs.

Background: Undifferentiated embryonic cell transcription factor 1 (UTF1) is predominantly expressed in pluripotent stem cells and plays a vital role in embryonic development and pluripotency maintenance. Despite its established importance in murine models, the role of UTF1 on human induced pluripotent stem cells (iPSCs) has not been comprehensively studied.

Methods: This study utilized CRISPR/Cas9 gene editing to create UTF1 knockout in human fibroblasts and iPSCs.

Forecasting cardiovascular disease mortality using artificial neural networks in Sindh, Pakistan.

Cardiovascular disease (CVD) is a leading cause of death and disability worldwide, and its incidence and prevalence are increasing in many countries. Modeling of CVD plays a crucial role in understanding the trend of CVD death cases, evaluating the effectiveness of interventions, and predicting future disease trends. This study aims to investigate the modeling and forecasting of CVD mortality, specifically in the Sindh province of Pakistan.

Measurement of natural radionuclides and health risk assessment in soil samples of the Main Central Thrust region in Garhwal Himalaya, India.

Ionizing radiation emitted from radionuclides is present everywhere in the environment. It is the main source of health hazards to the general public. The present study elaborates on the analysis of primordial radionuclides in the collected soil samples from the Main Central Thrust (MCT) region of Uttarakhand Himalaya in a grid pattern.

Dermoscopic findings in chronic venous insufficiency.

Background: Chronic venous insufficiency (CVI) causes cutaneous changes. This prospective observational study reveals dermoscopic findings in CVI.

Methods: Successive CVI patients of ≥18 years were included in the study.

Exploring prospects, hurdles, and road ahead for generative artificial intelligence in orthopedic education and training.

Generative Artificial Intelligence (AI), characterized by its ability to generate diverse forms of content including text, images, video and audio, has revolutionized many fields, including medical education. Generative AI leverages machine learning to create diverse content, enabling personalized learning, enhancing resource accessibility, and facilitating interactive case studies. This narrative review explores the integration of generative artificial intelligence (AI) into orthopedic education and training, highlighting its potential, current challenges, and future trajectory.

Synthetic MRI derived relaxometry parameters: a new insight into characterization of ring enhancing lesions of brain.

Background And Purpose: Synthetic MRI utilizes the quantitative relaxometry parameters to generate multiple contrast images through a single acquisition. We tried to explore the utility of synthetic MRI derived relaxometry parameters in evaluation of ring enhancing lesions of brain.

Materials And Methods: This was a prospective study.

To evaluate the effect of a structured training program about polycystic ovarian syndrome on the knowledge and perception of nursing students of a government nursing teaching institute in Northern India.

Background: The education levels of females have been found to aid in the early detection of polycystic ovary syndrome (PCOS). Early diagnosis and treatment are crucial in mitigating the long-term consequences of PCOS. Nursing students are poised to become the next generation of healthcare professionals, equipped with valuable knowledge that can be utilized to increase awareness among their peers and patients, particularly about this critical subject matter.

Prevalence of self-reported symptoms of reproductive tract infections and promoting an awareness of reproductive health among adolescent girls through education approach in Kumbakonam rural region of Tamil Nadu state.

Introduction: Adolescent females in India particularly from rural areas indicate sparse sexual and reproductive health (SRH) information and are at risk of unfavourable sexual and reproductive health outcomes.

Objectives: The study was primarily intended to assess the effect of structured interventional education on awareness and practices of school-going adolescent girls about sexual and reproductive health.

Methods: This was an interventional study comprising of interactive strategies, namely peer-led approach, flipped learning, skit, scenario-based discussion and puppetry.

Remission of type 2 diabetes mellitus: Emerging concepts and proposed diagnostic criteria.

The remission of type 2 diabetes mellitus (T2DM) is a topic that has been widely discussed recently, and it gives new hope for people with T2DM. Achievement of normal blood glucose levels or levels below the diagnostic threshold for T2DM without pharmacotherapy among people with T2DM after metabolic surgery and carbohydrate or calorie-restricted diet paved the way for more enthusiastic research in this area. There is a lot of confusion regarding the appropriate terminology and definition of remission of T2DM.

Health literacy and tobacco cessation among hypertensive individuals: A mixed method study.

Background: Hypertension and tobacco addiction are two major public health challenges in India that frequently coexist. About 30% of Indian adults have hypertension, while over one-fourth use some form of tobacco. So, the present study aimed to determine the prevalence and patterns of tobacco consumption and identify associated socio-demographic factors among hypertensive patients in urban India and also further explored patient perspectives regarding tobacco use through qualitative interviews.

Comparing skills-based and lecture-based education on female adolescents' knowledge, attitudes, and practices regarding menstrual health in puberty: A quasi-experimental study.

Background: Improving the health knowledge, attitudes, and practices (KAP) of female adolescents during puberty is essential for their well-being, empowerment, and prospects. To compare the effects of skills-based versus lecture-based education on KAP regarding menstrual health among adolescent girls in Gujarat, India.

Materials And Methods: A quasi-experimental study with 100 girls aged 12-16 years assigned to skills-based (n = 50) or lecture-based (n = 50) 8-week puberty education programs.

MONARCH Inventory for Causal Attribution in Homeopathy Case Reports: Explanation and Elaboration.

Background:  The Modified Naranjo Criteria for Homeopathy (MONARCH) inventory is a novel and useful tool for assessing the likelihood of a causal relationship between the homeopathic intervention and the ultimate clinical outcome.

Objectives:  To explain and elaborate on the use of the MONARCH inventory to improve its consistency of use and thereby elevate the overall quality and evidentiary value of homeopathy case reports.

Explanation And Elaboration:  Each of the 10 MONARCH inventory domains is explained and elaborated with the aid of references from published literature and hypothetical clinical situations.

Impact of maternal thyroid dysfunction on fetal and maternal outcomes in pregnancy: a prospective cohort study.

Background: Thyroid dysfunction in pregnancy can adversely impact maternal and fetal outcomes. However, the association between thyroid status and specific adverse outcomes needs clarity, especially in understudied regions.

Objective: This prospective cohort study aimed to illuminate the multifaceted associations between maternal thyroid dysfunction and feto-maternal outcomes in Gujarat, India.

A prospective, multicentre study evaluating safety and efficacy of a fixed dose combination of Remogliflozin etabonate, Vildagliptin, and Metformin in Indian patients with type 2 diabetes mellitus (Triad-RMV).

Aims: The ICMR INDIAB-17 study revealed a diabetes prevalence of 11.4% in India, emphasizing the need for effective treatment for glycemic control. A Phase IV study was conducted to evaluate the safety and efficacy of a Fixed Dose Combination (FDC) of Remogliflozin, Metformin and Vildagliptin (RMV) in Type 2 Diabetes Mellitus (T2DM) patients uncontrolled on Metformin plus SGLT2 inhibitor or Metformin plus DPP4 inhibitor dual therapy.

Exploring the antidiabetic activity of potential probiotic bacteria isolated from traditional fermented beverage.

Type 2 Diabetes continues to be one of the major public health issues worldwide without any sustainable cure. The modulation of gut microbiota is believed to be caused by probiotic bacteria and several probiotic strains have previously shown antidiabetic activity. The present study aims to isolate potential probiotic bacteria from traditionally used fermented rice beer of Assam, India and to investigate its anti-hyperglycemic effect.

Ethidium Bromide Degradation by Cold Atmospheric Plasma in Water and the Assessment of Byproduct Toxicity for Environmental Protection.

Ethidium bromide (Et-Br) is a widely used fluorescent dye in molecular biology and biotechnology laboratories for visualizing nucleic acids in agarose gel electrophoresis. However, concerns have been raised about its environmental impact and potential health risks due to its persistence and toxicity. The potential accumulation and long-term effects on the environment necessitate the removal of Et-Br from water.

Comparison of efficacy and safety between palonosetron and ondansetron to prevent postoperative nausea and vomiting in patients undergoing laparoscopic surgery: a systematic review and meta-analysis.

Purpose: Postoperative nausea and vomiting (PONV) is a prevalent and distressing complication, especially in laparoscopic surgeries. This review compares the efficacy and safety of palonosetron and ondansetron in preventing PONV after laparoscopic surgery.

Methods: A systematic review was conducted in PubMed, Google Scholar, Semantic Scholar, and Cochrane Library to identify comparative studies that reported the efficacy (nausea and vomiting) at three postoperative time points T1 (0-2 hours), T2 (2-6 hours), T3 (6-24 hours) and safety (incidence of adverse effects).

Association of oral cancer site with addiction and sociodemographic characteristics: A cross-sectional study conducted at a tertiary health centre.

Introduction: In contemporary epidemic scenarios, oral cancer ranks the top 3 cancer types afflicting the Indian population. The primary risk factors include alcohol consumption, tobacco usage in various forms, such as cigarettes and smokeless tobacco, betelnut chewing, and infection with the human papillomavirus. This article submitted in preprint in medRxiv on 20 February 2024.