2,542 results match your criteria: "Govt. Medical College & S.S.G.Hospital[Affiliation]"

Background: Choosing an appropriate course of treatment for midface fracture can be challenging due to the variable presentations of midfacial fractures and concurrent orbital floor injuries.

Objectives: To evaluate complications of midface fracture including the orbital floor.

Materials And Methods: It was a cross-sectional study carried out on 456 patients diagnosed with midface fracture, including the orbital floor, clinically and radiographically.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to explore the connection between lip and tongue print patterns and blood types among participants.
  • A total of 154 individuals (103 females and 51 males) participated in the research after consenting to the study's objectives.
  • Although the research identified gender differences in lip and tongue patterns related to blood groups, no statistically significant links were found between these variables.
View Article and Find Full Text PDF

Introduction: Orthodontic treatment can alter the oral environment, leading to plaque accumulation and changes in microbial colonization. This study aimed to assess microbiological changes in 10 to 16-year-old children undergoing fixed orthodontic treatment.

Methodology: The study included children aged 10-16 years, with one group wearing fixed orthodontic appliances and a control group without brackets.

View Article and Find Full Text PDF

Current Challenges of Vaccination in Fish Health Management.

Animals (Basel)

September 2024

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.

Article Synopsis
  • - Vaccination is crucial for the health management of all animals, particularly in inland aquaculture, to prevent diseases in fish broodstocks and enhance healthy seed production.
  • - In 2020, aquaculture produced 90.3 million tons of fish, but there was a 4% decline in inland aquaculture production compared to 2018, highlighting the impact of infectious diseases that resulted in significant financial losses.
  • - Innovative vaccination methods, such as using autogenous vaccines and incorporating vaccines in fish feed, are being explored to improve effectiveness and reduce reliance on antibiotics, ultimately aiming to minimize environmental contamination.
View Article and Find Full Text PDF

Upper tract urothelial carcinoma (UTUC) is a rare and aggressive malignancy with a poor prognosis. The accurate prediction of survival and recurrence in UTUC is crucial for effective risk stratification and guiding therapeutic decisions. Models combining radiomics and clinicopathological data features derived from computed tomographic urograms (CTUs) can be a way to predict survival and recurrence in UTUC.

View Article and Find Full Text PDF

Objective: We described mortality and loss to follow-up (LTFU) in children and adolescents who were under care for more than 5 years following initiation of antiretroviral therapy (ART).

Methods: Patients were followed from 5 years after ART until the earlier of their 25th birthday, last visit, death, or LTFU. We used Cox regression to assess predictors of mortality and competing risk regression to assess factors associated with LTFU.

View Article and Find Full Text PDF
Article Synopsis
  • A study investigated the effectiveness of individualized homeopathic medicinal products (IHMPs) compared to placebos for improving health-related quality of life in individuals suffering from post-COVID-19 conditions, with up to 80% of infected individuals experiencing ongoing symptoms.* -
  • Conducted at a medical college in India, the trial involved 60 participants divided into two groups: one receiving IHMPs plus care and the other receiving placebos plus care. The study tracked health outcomes over three months using established assessment tools.* -
  • Results showed that IHMPs significantly outperformed placebos in reducing post-COVID-19 symptoms, with notable improvements in both primary and secondary outcome measures, suggesting promise for homeopathic treatments in future
View Article and Find Full Text PDF

Background: Obesity is rising globally. Normal weight obesity (NWO) and normal weight central obesity (NWCO) despite normal BMI pose added metabolic risks. Limited data on these phenotypes among Indian doctors merits investigation.

View Article and Find Full Text PDF

Objectives: Available literature highlights the effectiveness of Acupuncture or Acupressure on the Spleen 6 acupoint ( or SP-6) for pain management in primary dysmenorrhea (PD). The objective of the current systematic review and meta-analysis is to provide an updated assessment of available randomized and non-randomized controlled trials and to compare the effectiveness of acupressure and acupuncture stimulation of among patients with PD.

Methods: We conducted a comprehensive literature search on various electronic databases including Embase, PubMed, and the Cochrane Library from January 1990 to March 2023 to identify the comparative studies (randomized and non-randomized controlled trials) that assessed the effects of acupressure or acupuncture on the acupoint in patients with PD.

View Article and Find Full Text PDF

Harnessing PROTACs to combat H5N1 influenza: A new frontier in viral destruction.

J Med Virol

September 2024

Department of Physics, Bernal Institute and Limerick Digital Cancer Research Centre (LDCRC), University of Limerick, Castletroy, Ireland.

H5N1, a highly pathogenic avian influenza virus, poses an ongoing and significant threat to global public health, primarily due to its potential to cause severe respiratory illness and high mortality rates in humans. Despite extensive efforts in vaccination and antiviral therapy, H5N1 continues to exhibit high mutation rates, resulting in recurrent outbreaks and the emergence of drug-resistant strains. Traditional antiviral therapies, such as neuraminidase inhibitors and M2 ion channel blockers, have demonstrated limited efficacy, necessitating the exploration of innovative therapeutic strategies.

View Article and Find Full Text PDF

In the past few decades, super-specialization has gained popularity in many medical disciplines. It provides professionals with a sturdy platform for advanced research and helps to deliver focused and extensive care in the fields of trauma and critical care, which can translate into good clinical outcomes for patients. Although this drift may bring about novel research opportunities, it may limit the number of doctors attending to the basic healthcare needs of the population.

View Article and Find Full Text PDF

The current study explored HPV prevalence and age variation in cervical samples of different cytological categories and HPV types from women seeking gynecological care in Tripura, northeast India. Pap smears, cervical tissues, and HPV/DNA specimens were collected from gynecological outpatient departments (OPD) or in-house patients and were screened for HPV16, HPV18, and other HPV types by PCR. Finally, logistic regression was performed to find the association between epidemiologic factors and HPV infection in women of different cytological grades.

View Article and Find Full Text PDF

Nanotechnology-assisted combination drug delivery: a progressive approach for the treatment of acute myeloid leukemia.

Ther Deliv

October 2024

Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences & Research (DIPSAR), Delhi Pharmaceutical Sciences & Research University, Pushp Vihar, Govt. of NCT of Delhi, New Delhi, 110017, India.

Acute myeloid leukemia (AML), a heterogeneous hematopoietic cancer prevalent in adults, has been a leading cause of leukemia-associated deaths for decades. Despite advancements in understanding its pathology and pharmacological targets, therapeutic strategies have seen minimal change. The standard treatment, combining cytarabine and anthracycline, has persisted, accompanied by challenges such as pharmacokinetic issues and non-specific drug delivery, leading to severe side effects.

View Article and Find Full Text PDF

Background And Objectives: Cervical cancer global burden is highly skewed towards poor countries primarily due to lack of awareness, poor screening, and low uptake of prophylactic vaccines. The purpose of our study is to educate and raise awareness among young girls and women about the importance of cervical screening and HPV vaccination.

Materials And Methods: The present study, conducted from January 2023 to December 2023, focused on students, teachers, housewives, and healthcare professionals in the Jammu region to assess their awareness of cervical cancer and the HPV vaccine.

View Article and Find Full Text PDF

Coumarins as versatile therapeutic phytomolecules: A systematic review.

Phytomedicine

November 2024

Department of Chemistry, University of Allahabad, Prayagraj (Allahabad) 211002, India; Department of Chemistry, G. R. P. B. Degree College, P. R. S. University, Prayagraj (Allahabad) 211010, India. Electronic address:

Article Synopsis
  • - Coumarins are small compounds found in many natural products and drugs, known for their diverse biological activities and significant pharmacological potential.
  • - This study reviews the role of coumarins in modern drug discovery, highlighting their therapeutic effects and mechanisms of action against various diseases, including cancer and neurodegenerative disorders.
  • - The findings emphasize the importance of natural coumarins in medicinal chemistry, pointing to their varied biological effects and urging more research to leverage their potential in drug development.
View Article and Find Full Text PDF

Poliovirus on the rise in Pakistan amidst unprecedented floods and COVID-19 pandemic: An urgent concern.

Health Sci Rep

September 2024

Department of Research The Medical Research Circle Goma Democratic Republic of Congo.

Background: Poliomyelitis is always a great concern in Pakistan and is a public health emergency. COVID-19 and recent floods have increased the challenge.

Aim: This article highlights the situation of polio in Pakistan and also recommends several steps to eradicate the disease as early as possible.

View Article and Find Full Text PDF

Background: Infections with Soil-transmitted Helminths (STHs) impact about 24% of the global population. A disproportionate number of individuals, particularly those from low socioeconomic backgrounds, live in emerging nations. In India, between the ages of one and fourteen, almost 220 million children are susceptible to intestinal worm infestations caused by parasites.

View Article and Find Full Text PDF

Background: Localized cutaneous leishmaniasis (LCL) is a chronic ulcerating disease. A literature review identified inconsistencies in clinical trials. The aims of this study were to reach a consensus on the most important domains to measure when assessing LCL, agree on parameters to measure the domains, and develop a tool representing a Core Outcome Set (COS), for use in clinical assessment of LCL.

View Article and Find Full Text PDF

The present paper is a comprehensive study on the optimization of ultrasonic assisted extraction and characterization of valued components from the newly developed garlic cultivar NARC-G1. The response surface methodology was employed to optimize the extraction time, solvent-to-solid ratio and extraction temperature, for optimal total phenolic contents (TPC), DPPH radical scavenging activity, α-amylase inhibition, and α-glucosidase inhibition. Under the optimized conditions (23 min extraction time, 60 °C temperature, and 39 : 1 solvent-to-solute ratio) the optimal TPC (13.

View Article and Find Full Text PDF