3 results match your criteria: "Govt. Lady Reading Hospital. Peshawar[Affiliation]"
The likelihood approach for potential role of "GABRG2 (C588T, C315T) gene polymorphisms" on the poor response to carbamazepine therapy in Pakhtun population of Pakistan.
Medicine (Baltimore)
October 2022
Dean College of Medicine, Shaqra, Riyad, Saudi Arabia.
Background: Gamma-aminobutyric acid A receptor, gamma 2 gene (GABRG2) encode the GABAA receptor which is responsible for fast neuronal inhibition. Polymorphisms in GABGR2 gene affect the clinical response of anti-epileptic drugs (AEDs). Therefore, we carried out an updated study to find the association GABRG2 gene polymorphisms with carbamazepine (CBZ) non-responsive therapy in the Pakhtun population.
View Article and Find Full Text PDFEpilepsy control with carbamazepine monotherapy from a genetic perspective.
BMC Pharmacol Toxicol
November 2018
Department of Pharmacology Institute of Basic Medical Science, Khyber Medical University, Peshawar, Khyber Pakhtunkhwa, Pakistan.
Background: Ethnicity variation is one of the main factors that may affect drug response in clinical practice. As MTHFR gene affects different transcriptome and proteome which affect the clinical response of drugs. Purpose of the current study was to observe possible variations in plasma levels of carbamazepine monotherapy and seizures' control in Pakhtun population of Khyber Pakhtunkhwa (KP) in the context of MTHFR (C677T and A1298C) gene polymorphisms.
View Article and Find Full Text PDFPrevalence of non alcoholic fatty liver and Non alcoholic Steatohepatitis in Peshawar Cantonment, Khyber Pakhtunkhwa, Pakistan.
Pak J Pharm Sci
January 2018
Department of Medicine, Govt. Lady Reading Hospital. Peshawar, Pakistan.
Article Synopsis
- The study aimed to establish the prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) among patients aged 20-65 at a military hospital in Pakistan from June 2013 to June 2014.
- Overall, the prevalence of NAFLD was found to be 47%, with 12.3% of patients diagnosed with NASH, particularly higher in Pathan individuals compared to Punjabies and Sindhies.
- Results indicated that men, diabetics, and hypertensive individuals, as well as those with higher BMI and poor exercise habits, were significantly more likely to have NAFLD and NASH.