Biological Activities of In-House Developed Plant Extract Formulations.

The therapeutic potential of whitish glaucous sub-shrub (. ), abundantly present in southern regions of South Asia, has been neglected. The current study aimed to assess the phytochemicals and pharmacological potential of native and gemm forms of .

Insect-fungal-interactions: A detailed review on entomopathogenic fungi pathogenicity to combat insect pests.

Global food security is threatened by insect pests of economically important crops. Chemical pesticides have been used frequently for the last few decades to manage insect pests throughout the world. However, these chemicals are hazardous for human health as well as the ecosystem.

Acacia modesta attenuates MnCl2 induced hepatotoxicity, oxidative stress and hepatic inflammation in wistar rats.

Natural Plants are broadly used in treating inflammatory disorders. The current study focused on evaluating the hepato-protective and anti-inflammatory potential of A. modesta in MnCL induced hepatotoxicity and liver inflammation.

Role of religiosity, optimism, demographic characteristics and mental health problems among cancer patients.

Objective: To investigate the role of religiosity, optimism, depression, death anxiety and differences in demographic characteristics among cancer patients.

Methods: The cross-sectional study was conducted from July 2018 to July 2019 in three different hospitals of Lahore and Faisalabad, Pakistan, and comprised patients with diagnosed stage 1 and 2 cancer. Non-cancer subjects were enrolled as the control group.

Toxicological Screening of 4-Phenyl-3,4-dihydrobenzo[]quinolin-2(1)-one: A New Potential Candidate for Alzheimer's Treatment.

Toxicity studies are necessary for the development of a new drug. Naphthalene is a bicyclic molecule and is easy to derivatize. In our previous study, a derivative of naphthalene (4-phenyl,3,4-dihydrobenzoquinoline-2()one) was synthesized and reported its in vitro activity on different enzymes.

Toxicity Evaluation of the Naphthalen-2-yl 3,5-Dinitrobenzoate: A Drug Candidate for Alzheimer Disease.

The presented study was designed to probe the toxicity potential of newly identified compound naphthalen-2-yl 3,5-dinitrobenzoate (SF1). Acute, subacute toxicity and teratogenicity studies were performed as per Organization of economic cooperation and development (OECD) 425, 407, and 414 test guidelines, respectively. An oral dose of 2000 mg/kg to rats for acute toxicity.

Medicinal plants resources of Western Himalayan Palas Valley, Indus Kohistan, Pakistan: Their uses and degrees of risk of extinction.

Present study was intended with the aim to document the pre-existence traditional knowledge and ethnomedicinal uses of plant species in the Palas valley. Data were collected during 2015-2016 to explore plants resource, their utilization and documentation of the indigenous knowledge. The current study reported a total of 65 medicinal plant species of 57 genera belonging to 40 families.

Hematological and toxicological effects of aqueous leaf extract of Stevia rebaudiana Bertoni in normal rat modals.

Stevia rebaudiana Bertoni a non-caloric, safe and natural sweetener has been shown pharmaceutically important in the management of blood disorders. This study was designed to investigate hematology and safety of stevia aqueous extract through animal modeling. For this purpose, fifty albino rats were categorized into 5 groups and all the groups were received aqueous stevia extract at different dosage levels (200, 300, 400 and 500 ppm/kg b.

Screening, selection and development of apr-IBL04 for hyper production of macromolecule alkaline protease.

microbe is commonly found in soil and produces proteases on nitrogen and carbon-containing sources and increases the fertility rate by degrading nitrogenous organic materials. The present study was aimed to develop hyper producing mutant strain of for the production of proteases, to improve the process variables by the response surface methodology (RSM) under central composite design (CCD) and the production of protease by the particular mutant strain in a liquid state fermentation media. The mutation of the strain was carried out using ethidium bromide.

Mathematical modeling and experimental analysis of the efficacy of photodynamic therapy in conjunction with photo thermal therapy and PEG-coated Au-doped TiO nanostructures to target MCF-7 cancerous cells.

Some nanoscale morphologies of titanium oxide nanostructures blend with gold nanoparticles and act as satellites and targeted weapon methodologies in biomedical applications. Simultaneously, titanium oxide can play an important role when combined with gold after blending with polyethylene glycol (PEG). Our experimental approach is novel with respect to the plasmonic role of metal nanoparticles as an efficient PDT drug.

Insight of transcriptional regulators reveals the tolerance mechanism of carpet-grass (Axonopus compressus) against drought.

Background: Carpet grass [Axonopus compressus (L.)] is an important warm-season perennial grass around the world and is known for its adaptability to varied environmental conditions. However, Carpet grass lacks enough data in public data banks, which confined our comprehension of the mechanisms of environmental adaptations, gene discovery, and development of molecular markers.

ab initio study of oxygen vacancy effects on structural, electronic and thermoelectric behavior of AZrMO (A = Ba, Ca, Sr; M= Al, Cu, x = 0.25) for application of memory devices.

The structural, electronic and thermoelectric properties of AZrMO (A = Ba, Ca, Sr; M = Al, Cu, x = 0.25) without and with an oxygen vacancy (Vo) have been unveiled using the Perdew-Burke-Ernzerhof Generalized Gradient Approximation (PBE-GGA) functional along with Tran-Blaha modified Becke-Jonhson (TB-mBJ)approximation based on Density Functional Theory (DFT) in the framework of WIEN2k code for memristors applications. Moreover, isosurface charge density plots have been calculated by using Vienna ab initio Simulation Package (VASP) simulation code.

A systematic review on chromatography-based method validation for quantification of vancomycin in biological matrices.

A fully validated bioanalytical methods are prerequisite for pharmacokinetic and bioequivalence studies as well as for therapeutic drug monitoring. Due to high pharmacokinetic variability and narrow therapeutic index, vancomycin requires reliable quantification methods for therapeutic drug monitoring. To identify published chromatographic based bioanalytical methods for vancomycin in current systematic review, PubMed and ScienceDirect databases were searched.

Dopamine Alleviates Hydrocarbon Stress in Brassica oleracea through Modulation of Physio-Biochemical Attributes and Antioxidant Defense Systems.

Hydrocarbon stress has become one of the most restrictive factors for crop choice and productivity in most parts of the world. Dopamine (DA) has positively influenced the metabolic, physiological and biochemical activities besides the growth of plants under numerous abiotic stress conditions. The current study was performed to analyze the potential of DA to alleviate hydrocarbon stress and improve growth of Brassica oleracea plants.

Individualised cognitive behaviour therapy in patients of substance use disorders: three case studies.

The current study aims to investigate the effectiveness of Cognitive Behaviour Therapy (CBT) in the treatment of patients with substance use disorders. Three diagnosed patients with substance use disorders were recruited -i.e.

Effect of Venlafaxine, Pramipexole, and Valsartan on Spermatogenesis in Male Rats.

The study's aim was to explore the effect of venlafaxine, valsartan, and pramipexole on spermatogenesis. It was hypothesized that these drugs may affect the male fertility because of their long-term use in treatment of depression, hypertension, and Parkinson's diseases. Male rats were given venlafaxine, valsartan, and pramipexole at low- and high-dose levels orally once daily for 10 weeks.

Plasma Surfactant Protein-A Levels In Healthy Subjects And Chronic Obstructive Pulmonary Disease Patients.

Background: Chronic Obstructive Pulmonary Disease (COPD) is the leading cause of morbidity and mortality across the globe. Currently, there is a dearth of biomarkers which can accurately diagnose and evaluate the prognosis of the disease. Systemic Surfactant Protein- A (SP-A) levels are generally higher in smokers compared to non-smokers as well as elevated in COPD patients as compared to controls.

Locomotion of an efficient biomechanical sperm through viscoelastic medium.

Every group of microorganism utilizes a diverse mechanical strategy to propel through complex environments. These swimming problems deal with the fluid-organism interaction at micro-scales in which Reynolds number is of the order of 10. By adopting the same propulsion mechanism of so-called Taylor's sheet, here we address the biomechanical principle of swimming via different wavy surfaces.

Ab-initio prediction of the mechanical, magnetic and thermoelectric behaviour of perovskite oxides XGaO (X = Sc, Ti, Ag) using LDA+U functional: For optoelectronic devices.

The mechanical, magnetic and thermoelectric properties of spin polarized XGaO (X = Sc, Ti, Ag) perovskite oxides in cubic phase have been investigated using LDA + U functional through ab-initio study based on density functional theory (DFT) in the framework of WIEN2K simulation code. The Full Potential Linearized Augmented Plane Wave (FP-LAPW) technique along with PBE-GGA functional have been used to optimize the systems and determining exchange-correlation potential. However, in order to address on-site self-interactions error and overcome limitations of PBE-GGA functional, LDA + U has been employed because Hubbard parameter 'U' is found an appropriate remedy to consider on-site self-interactions, and to calculate improved electronic energy band gap.

A review on detection of heavy metals from aqueous media using nanomaterial-based sensors.

The extensive release of heavy metals into the natural water bodies has become globally prevalent from past few decades. Heavy metal toxicity is becoming a serious threat to human and the environment. Due to their prolonged half-life, potential accumulation in different parts of body, and non-biodegradability, metal ions are being obvious entities that can cause several hazardous health risks.

Synthesis of a Fluorescent Whitening Molecule and its Application to Wool Fibres.

Aim And Objective: Reactive dye molecules are commonly employed to dye or modify colour characteristics of wool fibres. Yellowness of wool fibres poses a challenge and here, we report synthesis of a reactive fluorescent molecule and its application to wool fibres to reduce yellowness of the wool fibre and improve its colour features.

Material And Methods: The new molecule was based upon 7-amino-4-methylcoumarin (AMC) and 2,4,6- trichloro-1,3,5-triazine (TZT).

A new approach to design 3(3-sulfamoylbenzamido) benzoic acid containing transition metal complexes: Characterization and Biological activities.

Zn, Cu, Co and Ni are biocompatible metals as they are active center of many enzymes in the human body. Incorporation of these biocompatible metals into 3-(o-Sulfamoylphenyl) carbamoylbenzoic acid (I) makes them able to prove an excellent antimicrobial agent. In the present study Ni (II), Co (II), Cu(II) and Zn (II) complexes (III-VI) were synthesized from ligand (I) derive from 3-(o-Sulfamoylphenyl) carbamoylbenzoic acid and zinc, nickel, cobalt acetate tetrahydrate/copper acetate monohydrate.

Motility effects biofilm formation in Pseudomonas aeruginosa and Enterobacter cloacae.

Chronic infections caused by gram negative bacteria are the mains reasons to have morbidity and death in patients, despite using high doses of antibiotics applied to cure diseases producing by them. This study was designed to identify the role of flagella in biofilm formation Ten pure strains were collected from our lab. Morphological variation and motility assays led us to study two strains in detail.

Quality of life before and after total knee arthroplasty in clinical settings across Lahore, Pakistan.

Knee osteoarthritis is a common disabling condition that affects a larger number of populations aged above 40 years and this habitually required knee arthroplasty to reinstate leg function, to improve the pain as well as to improve stability. The main objective of this study was to determine the health-related quality of lifestyle before and after total knee arthroplasty. This study was a cross-sectional observational study conducted at Shaukat Khanum Memorial Cancer Hospital & Research Centre, Horizon Hospital and Mayo Hospital, Lahore-Pakistan.