Does knowledge impact adherence?: correlation between HIV-infected pregnant women's knowledge of WHO-recommended PMTCT guidelines and their adherence to the PMTCT program in India.

WHO's 2013 PMTCT guidelines recommended lifelong antiretroviral therapy (ART) for HIV-infected pregnant and breastfeeding women, exclusive breastfeeding (EBF), nevirapine prophylaxis (NVP) and early infant diagnosis (EID) for HIV-exposed-breastfed infants. We examined the association between knowledge and adherence to these guidelines among 550 HIV-infected pregnant women in Maharashtra, India. Knowledge of PMTCT guidelines was assessed using a structured-questionnaire during enrollment.

Interbreed variation of dairy cow milk in terms of specific proteome and lipidome for establishing criteria of milk selection.

Background: Ruminant milk is a very complex table food and naturally encrypted with different components possessing various health-promoting characteristics.

Aim: In the present study, we focused on breed-wise compositional difference in milk including various components and release of fatty acids and peptides during digestion.

Methods: First, milk samples were analysed using lactoscan LW milk analyser, MALDI-TOF and gas chromatography.

Undergraduate psychiatry CBME curriculum revision: The process and the way ahead.

Nationa Medical Commission (NMC) had recently undertook the revision of Undergraduate CBME curriculum. the Authors were involved in Psychiatry curriculum revision. In this paper, authors explain the process of revision, the rationale behind the changes made and make specific suggestions for the better implementation of the revised curriculum.

Exploring prospects, hurdles, and road ahead for generative artificial intelligence in orthopedic education and training.

Generative Artificial Intelligence (AI), characterized by its ability to generate diverse forms of content including text, images, video and audio, has revolutionized many fields, including medical education. Generative AI leverages machine learning to create diverse content, enabling personalized learning, enhancing resource accessibility, and facilitating interactive case studies. This narrative review explores the integration of generative artificial intelligence (AI) into orthopedic education and training, highlighting its potential, current challenges, and future trajectory.

Synthetic MRI derived relaxometry parameters: a new insight into characterization of ring enhancing lesions of brain.

Background And Purpose: Synthetic MRI utilizes the quantitative relaxometry parameters to generate multiple contrast images through a single acquisition. We tried to explore the utility of synthetic MRI derived relaxometry parameters in evaluation of ring enhancing lesions of brain.

Materials And Methods: This was a prospective study.

Prevalence of self-reported symptoms of reproductive tract infections and promoting an awareness of reproductive health among adolescent girls through education approach in Kumbakonam rural region of Tamil Nadu state.

Introduction: Adolescent females in India particularly from rural areas indicate sparse sexual and reproductive health (SRH) information and are at risk of unfavourable sexual and reproductive health outcomes.

Objectives: The study was primarily intended to assess the effect of structured interventional education on awareness and practices of school-going adolescent girls about sexual and reproductive health.

Methods: This was an interventional study comprising of interactive strategies, namely peer-led approach, flipped learning, skit, scenario-based discussion and puppetry.

Remission of type 2 diabetes mellitus: Emerging concepts and proposed diagnostic criteria.

The remission of type 2 diabetes mellitus (T2DM) is a topic that has been widely discussed recently, and it gives new hope for people with T2DM. Achievement of normal blood glucose levels or levels below the diagnostic threshold for T2DM without pharmacotherapy among people with T2DM after metabolic surgery and carbohydrate or calorie-restricted diet paved the way for more enthusiastic research in this area. There is a lot of confusion regarding the appropriate terminology and definition of remission of T2DM.

Health literacy and tobacco cessation among hypertensive individuals: A mixed method study.

Background: Hypertension and tobacco addiction are two major public health challenges in India that frequently coexist. About 30% of Indian adults have hypertension, while over one-fourth use some form of tobacco. So, the present study aimed to determine the prevalence and patterns of tobacco consumption and identify associated socio-demographic factors among hypertensive patients in urban India and also further explored patient perspectives regarding tobacco use through qualitative interviews.

Comparing skills-based and lecture-based education on female adolescents' knowledge, attitudes, and practices regarding menstrual health in puberty: A quasi-experimental study.

Background: Improving the health knowledge, attitudes, and practices (KAP) of female adolescents during puberty is essential for their well-being, empowerment, and prospects. To compare the effects of skills-based versus lecture-based education on KAP regarding menstrual health among adolescent girls in Gujarat, India.

Materials And Methods: A quasi-experimental study with 100 girls aged 12-16 years assigned to skills-based (n = 50) or lecture-based (n = 50) 8-week puberty education programs.

A prospective, multicentre study evaluating safety and efficacy of a fixed dose combination of Remogliflozin etabonate, Vildagliptin, and Metformin in Indian patients with type 2 diabetes mellitus (Triad-RMV).

Aims: The ICMR INDIAB-17 study revealed a diabetes prevalence of 11.4% in India, emphasizing the need for effective treatment for glycemic control. A Phase IV study was conducted to evaluate the safety and efficacy of a Fixed Dose Combination (FDC) of Remogliflozin, Metformin and Vildagliptin (RMV) in Type 2 Diabetes Mellitus (T2DM) patients uncontrolled on Metformin plus SGLT2 inhibitor or Metformin plus DPP4 inhibitor dual therapy.

Comparison of efficacy and safety between palonosetron and ondansetron to prevent postoperative nausea and vomiting in patients undergoing laparoscopic surgery: a systematic review and meta-analysis.

Purpose: Postoperative nausea and vomiting (PONV) is a prevalent and distressing complication, especially in laparoscopic surgeries. This review compares the efficacy and safety of palonosetron and ondansetron in preventing PONV after laparoscopic surgery.

Methods: A systematic review was conducted in PubMed, Google Scholar, Semantic Scholar, and Cochrane Library to identify comparative studies that reported the efficacy (nausea and vomiting) at three postoperative time points T1 (0-2 hours), T2 (2-6 hours), T3 (6-24 hours) and safety (incidence of adverse effects).

Association of oral cancer site with addiction and sociodemographic characteristics: A cross-sectional study conducted at a tertiary health centre.

Introduction: In contemporary epidemic scenarios, oral cancer ranks the top 3 cancer types afflicting the Indian population. The primary risk factors include alcohol consumption, tobacco usage in various forms, such as cigarettes and smokeless tobacco, betelnut chewing, and infection with the human papillomavirus. This article submitted in preprint in medRxiv on 20 February 2024.

Antimicrobial resistance genes and associated mobile genetic elements in Escherichia coli from human, animal and environment.

The global rise of antimicrobial resistance (AMR) poses a significant threat to human health. The environment plays an essential role in transmission of antimicrobial resistance genes (ARGs) between human and animal. Bacterial communities harbour diverse ARGs, carried by mobile genetic elements (MGEs) like plasmids and insertion sequences (ISs).

Decoding early-onset of colorectal cancer: Insights into SERPINA3 expression patterns.

Early-onset colorectal cancer (EOCRC), recognized as a distinct subgroup with an increased incidence over the past two decades, characterized by its aggressive nature and potentially unique molecular factors that differentiate it from traditional colorectal cancer (CRC). In this study, we investigated differentially expressed genes in a young-CRC patient using paired-end mRNA-sequencing. Validation of target genes through qRT-PCR highlighted a significant increase in SERPINA3 levels in EOCRC, representing a novel finding.

MIC trends of vancomycin and teicoplanin among methicillin resistant CoNS isolates from new born blood cultures in a tertiary care centre in Southern India.

Background And Objectives: Coagulase-negative-Staphylococci (CoNS) are important etiological agent of bacteraemia in newborn babies. Methicillin resistant CoNS infections have only limited treatment options. The antimicrobial susceptibility pattern of Methicillin Resistant CoNS isolates from newborn blood cultures was studied with special reference to MICs of Vancomycin and Teicoplanin.

Associations between cognitive disengagement syndrome, Internet addiction, and Internet gaming disorder among medical students - A cross-sectional study.

Background: Internet addiction (IA) and gaming disorder (IGD) are emerging public health concerns among youth. Sluggish cognitive tempo (SCT)/cognitive disengagement syndrome has been linked with risky online behaviors, but the literature on medical students is limited.

Aim: To determine associations between SCT, IA, and IGD in Indian medical undergraduates.

The Genomic Landscape of Wilson Disease in a Pan India Disease Cohort and Population-Scale Data.

Background: Wilson's disease (WD) results from pathogenic ATP7B gene variations, causing copper accumulation mainly in the liver, brain, and kidneys.

Objectives: In India, despite studies on ATP7B variants, WD often goes undiagnosed, with the prevalence, carrier rate, and mutation spectrum remaining unknown.

Methods: A multicenter study examined genetic variations in WD among individuals of Indian origin via whole exome sequencing.

Analysis of ventricular repolarization parameters and heart rate variability in obesity: a comparative study.

Obesity is associated with dysfunctional electrocardiographic and cardiac autonomic parameters, which may lead to increased cardiovascular morbidity. Novel electrocardiographic repolarization markers such as Tpeak-Tend (Tpe) interval have not yet been deeply studied in obese patients. We aimed to investigate the association between ventricular repolarization parameters and heart rate variability (HRV) and how they are affected by changes occurring in the cardiac autonomic nervous system.

Hypersensitive reaction due to ferric carboxymaltose in a post-partum mother experienced in a tertiary care hospital in West Bengal, India: A case report.

Iron deficiency anaemia (IDA) is highly associated with insufficient nutrition, chronic renal failure and congestive heart failure. Post-partum anaemia is also very common with a high mortality rate. Ferric carboxymaltose (FCM) is a non-dextran third-generation intravenous (IV)-iron preparation.