Drug-likeness analysis, in silico ADMET profiling of compounds in (Jacq.) Cogn, and antibacterial activity of the plant extract.

Plants are a treasure trove of bioactive compounds. (Jacq.) Cogn.

Phenolate-thiazole based reversible "turn-on" chemosensor for the selective detection of carbonate anion: X-ray crystallography, DFT/TDFT, and cell study.

A new phenolate-thiazole derivative (L) has been synthesized and structurally characterized.The chemo-sensing activity of L is detected by the naked eye for the aqueous carbonate anion in the pH range of 4 to 8. The selective 'turn-on' fluorescence occurs through the formation of a stable intermediate L∙CO(1) following the PET mechanism.

Transcriptomic profile in carbendazim-induced developmental defects in zebrafish (Danio rerio) embryos/larvae.

Carbendazim is a widely used fungicide to protect agricultural and horticultural crops against a wide array of fungal species. Published reports have shown that the wide usage of carbendazim resulted in reprotoxicity, carcinogenicity, immunotoxicity, and developmental toxicity in mammalian models. However, studies related to the developmental toxicity of carbendazim in aquatic organisms are not clear.

Synthesis of substituted 2H-Chromenes via Pd-catalyzed C-H activation and thermal cyclization.

A proficient approach has been developed for the synthesis of substituted 2H-chromenes from C1-substituted glucal. The key step of our synthetic methodology was C-H activation in propylene carbonate solvent followed by 6π-electrocyclization aromatization in ethylene glycol as greener substitutes to toxic aprotic solvents, to obtain 2H-chromenes in a stepwise manner. The application of the developed methodology was further explored with the synthesis of a small library of substituted 2H-chromenes in good yields.

Comparative study on the mutation spectrum of L-MYC and C-MYC genes of blood cfDNA in patients with ovarian cancer and healthy females.

Background: This study aimed at detecting the mutations of L-MYC and C-MYC genes in ovarian cancer (OC) patients and healthy female volunteers using cell-free DNA (cfDNA).

Methods: We evaluated cfDNA of 50 OC patients with different stages (I-IV) and 50 age-matched healthy female volunteers (controls) in order to access mutations in exon-1 of L-MYC (198 bp) and exon-3 of C-MYC (165 bp) genes using Sanger sequencing.

Results: The total mutations reported were 43 and 7 in exon-1 of L-MYC and exon-3 of C-MYC genes, respective.

COVID and depression among stratified population groups: a narrative review.

The Covid-19 pandemic has impacted and infiltrated every aspect of our lives. Successive lockdowns, social distancing measures, and reduction in economic activity have developed a new way of living and, in many cases, tend to lead to depression. The initial strict lockdown for about 3 months and eventually for a few more months has imposed greater challenges on children and adolescents in terms of psychological problems and psychiatric disorders.

-Glycopyranosyl aldehydes: emerging chiral synthons in organic synthesis.

Herein, we have summarized the vast array of synthetic processes that have been developed for the synthesis of -glycopyranosyl aldehydes and diverse -glycoconjugates derived from them by covering the literature reported from 1979 to 2023. Notwithstanding its challenging chemistry, -glycosides are considered stable pharmacophores and are used as important bioactive molecules. The discussed synthetic methodologies to access -glycopyranosyl aldehydes take advantage of seven key intermediates, allene, thiazole, dithiane, cyanide, alkene, and nitromethane.

Eco-friendly green synthesis of silver nanoparticles from leaf extract and their antimicrobial, antioxidant, anticancer and photocatalytic degradation activity.

The present research work, green synthesis of silver nanoparticles (Ag NPs) was synthesized from silver ions using the reducing and capping agents of leaf extract. Initially, UV-vis spectrophotometry absorption of the Surface Plasmon Resonance centre at 450 nm was confirmed the formation of Ag NPs. Preliminary phytochemical and FT-IR analysis indicate the identification of secondary metabolised flavonoids that act as the reducing and capping agent of the synthesized Ag NPs.

Facile green synthesis, analysis, in vitro antidiabetic and antimicrobial activity of ZnO macropores.

Rapid increase in population and development in industry causes many problems such as microbial contaminations and chronic diseases such as diabetes. Materials synthesized at nanoscale are novel antidiabetic and antimicrobial agents. ZnO nanoparticles with macropores characteristics are synthesized by green methods.

Comparative study of TNF-α and vitamin D reveals a significant role of TNF-α in NSCLC in an ethnically conserved vitamin D deficient population.

Growing evidence has implicated tumor necrosis factor-alpha (TNF-α) as an important regulator of the tumor microenvironment. Moreover, various molecular epidemiological studies have proposed vitamin D deficiency to be a mediator of cancer progression. Here we comparatively analyzed the role of TNF-α and vitamin D in non-small cell lung cancer (NSCLC) in an ethnically conserved vitamin D deficient population.

Correction: Diastereoselective synthesis of glycopyrans 1,2-annulated with dioxazinanes from 1,2-anhydrosugars and -substituted nitrones.

Correction for 'Diastereoselective synthesis of glycopyrans 1,2-annulated with dioxazinanes from 1,2-anhydrosugars and -substituted nitrones' by Ajaz Ahmed , , 2022, , 1436-1443, DOI: 10.1039/d1ob02310a.

Viscoelastic and smart swelling disposition of Carboxymethylcellulose based hydrogels substantiated by Gemini surfactant and in-vitro encapsulation and controlled release of Quercetin.

CMC-SA-12-E2-12 hydrogels were prepared from Carboxymethylcellulose (CMC), succinic acid (SA) (biocompatible cross-linker) and Ethane-1,2-diyl-bis(N, N-dimethyl-N-dodecylammoniumacetoxy) (referred as 12-E2-12) (0.0006, 0.0015, 0.

Instigating the Anticancer Activity of New Pyridine-Thiazole-Based Co(III), Mn(II), and Ni(II) Complexes: Synthesis, Structure, DFT, Docking, and MD Simulation Studies.

The perchlorate salt of (4-(4-methoxy phenyl)-2-(2-(1-pyridine-2-yl)ethylidene)hydrazinyl)thiazole () and its metal perchlorate derivatives, namely, [Co()]ClO (), [Mn()](ClO) (), and [Ni()](ClO) (), have been synthesized and characterized through single X-ray crystallography and spectroscopic methods. The ligand crystallizes in a space group 2/ in a nearly planar structure. The overall geometry of the complex salts is described as a distorted octahedron with a MN chromophore.

Corrigendum to "Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review".

[This corrects the article DOI: 10.1155/2017/1716701.].

Diastereoselective synthesis of glycopyrans 1,2-annulated with dioxazinanes from 1,2-anhydrosugars and -substituted nitrones.

1,2-Annulated pyranose sugars fused with six membered rings have emerged as an important class of carbohydrates with wide biological and synthetic utility. We now describe zinc chloride catalyzed one pot diastereoselective synthesis of sugar fused dioxazinanes from 1,2-anhydro sugars and -substituted aromatic nitrones. Various aromatic nitrones with different substituents undergo the reaction smoothly.

Kernel Estimation of Cumulative Residual Tsallis Entropy and Its Dynamic Version under -Mixing Dependent Data.

Tsallis introduced a non-logarithmic generalization of Shannon entropy, namely Tsallis entropy, which is non-extensive. Sati and Gupta proposed cumulative residual information based on this non-extensive entropy measure, namely cumulative residual Tsallis entropy (CRTE), and its dynamic version, namely dynamic cumulative residual Tsallis entropy (DCRTE). In the present paper, we propose non-parametric kernel type estimators for CRTE and DCRTE where the considered observations exhibit an ρ-mixing dependence condition.

Comparative Study of Different Methods of Synthesis and Their Effect on the Thermomechanical Properties of a Halogenated Epoxy-Based Flame-Retardant Resin.

The work presented in this paper deals with the comparative synthesis of diglycidyl ether-based tetrabromobisphenol-A(TBBPA) using both conventional and nonconventional methods in order to explore materials for better industrial applications with respect to effective yield, cost, and time consideration. The conventional method involved the polycondensation of TBBPA and epichlorohydrin in the presence of an alkali catalyst. The nonconventional routes adopted for the synthesis of the material involved ultrasonication, microwave irradiation, and UV light exposure.

Photocatalytic functionalizations of alkynes.

Visible light mediated functionalizations have significantly expanded the scope of alkynes by unraveling new mechanistic pathways and enabling their transformation to diverse structural entities. The photoredox reactions on alkynes rely on their innate capability to generate myriad carbon-centred radicals single electron transfer (SET), thereby, allowing the introduction of new radical precursors. Moreover, an array of methods have been developed facilitating transformations such as vicinal or -difunctionalization, annulation, cycloaddition and oxidative reactions to construct numerous key building blocks of natural and pharmaceutically important molecules.

A minireview of 1,2,3-triazole hybrids with O-heterocycles as leads in medicinal chemistry.

Over the past few decades, the dynamic progress in the synthesis and screening of heterocyclic compounds against various targets has made a significant contribution in the field of medicinal chemistry. Among the wide array of heterocyclic compounds, triazole moiety has attracted the attention of researchers owing to its vast therapeutic potential and easy preparation via copper and ruthenium-catalyzed azide-alkyne cycloaddition reactions. Triazole skeletons are found as major structural components in a different class of drugs possessing diverse pharmacological profiles including anti-cancer, anti-bacterial, anti-fungal, anti-viral, anti-oxidant, anti-inflammatory, anti-diabetic, anti-tubercular, and anti-depressant among various others.

Synthesis of New Naphthyl Aceto Hydrazone-Based Metal Complexes: Micellar Interactions, DNA Binding, Antimicrobial, and Cancer Inhibition Studies.

In the present study, naphthyl acetohydrazide (HL) ligand was prepared and used for the synthesis of new six amorphous transition metal (Co(II), Ni(II), Cu(II), Zn(II), Pb(II), Cd(II)) complexes. All the compounds were characterized by elemental analysis, UV-vis, FT-IR, H- and C-NMR, and Matrix-Assisted Laser Desorption Ionization (MALDI). The solubilization study was carried out by estimating the interaction between the metal complexes with surfactants viz.

Green synthesis of Copper Oxide/Carbon nanocomposites using the leaf extract of Nees, their characterization and antimicrobial activity.

Copper Oxide/Carbon (CuO/C) nanocomposites were developed through the green method using the leaf extract of at room temperature. Here, the leaf extract serves as a capping agent, reducing agent and a source of carbon for the formation of nanocomposites. As we know, this is the first article on the synthesis of CuO/C nanocomposites using this leaf extract.