Structural and functional implications of SLC13A3 and SLC9A6 mutations: an in silico approach to understanding intellectual disability.

Background: Intellectual disability (ID) is a condition that varies widely in both its clinical presentation and its genetic underpinnings. It significantly impacts patients' learning capacities and lowers their IQ below 70. The solute carrier (SLC) family is the most abundant class of transmembrane transporters and is responsible for the translocation of various substances across cell membranes, including nutrients, ions, metabolites, and medicines.

Biosynthesis and Characterization of Calcium Oxide Nanoparticles from Fruit Extracts; Their Biocompatibility and Bioactivities.

Modern nanotechnology encompasses every field of life. Nowadays, phytochemically fabricated nanoparticles are being widely studied for their bioactivities and biosafety. The present research studied the synthesis, characterization, stability, biocompatibility, and in vitro bioactivities of calcium oxide nanoparticles (CaONPs).

Multicriteria group decision making for COVID-19 testing facility based on picture cubic fuzzy aggregation information.

The information aggregation of cubic fuzzy numbers and picture fuzzy numbers have played an important role in decision making. This paper introduces a novel approach to address the problem of testing facility of COVID-19 under picture cubic fuzzy environment. As the picture cubic fuzzy set is a generalized fuzzy structure to handle more uncertainty and ambiguity in decision making problems We discuss its various properties.

Assessment of musculoskeletal disorders among cricketers playing in domestic clubs of Lahore.

Objective: To assess musculoskeletal disorders among male cricketers in an urban centre.

Methods: The cross-sectional study was conducted from October to November 2020 in Lahore, Pakistan, and comprised male cricket players aged 10-25 years playing in four domestic clubs. Data was collected about musculoskeletal disorders experienced during the preceding 12 months using the Extended Nordic Musculoskeletal Questionnaire.

Rational Design of Novel Inhibitors of α-Glucosidase: An Application of Quantitative Structure Activity Relationship and Structure-Based Virtual Screening.

α-Glucosidase is considered a prime drug target for Diabetes Mellitus and its inhibitors are used to delay carbohydrate digestion for the treatment of diabetes mellitus. With the aim to design α-glucosidase inhibitors with novel chemical scaffolds, three folds ligand and structure based virtual screening was applied. Initially linear quantitative structure activity relationship (QSAR) model was developed by a molecular operating environment (MOE) using a training set of thirty-two known inhibitors, which showed good correlation coefficient (r = 0.

tailoring the morphology of In(OH)nanostructures via surfactants during anodization and their transformation into InOnanoparticles.

The present work reports the effect of various surfactants on the morphology of In(OH)nanostructures prepared via anodization. In-sheets were anodized in an environmentally benign electrolyte containing a small quantity of CTAB, CTAC, and PDDA surfactants at room temperature. The produced nanostructures were characterized using XRD, HRTEM, SAED, and EDAX.

The distribution of Aedes aegypti (diptera, culicidae) in eight selected parks of Lahore, using oviposition traps during rainy season.

Objective: To investigate the seasonal distribution of immature habitat of Aedes aegypti mosquito species and its association with environmental and climatic conditions.

Methods: This descriptive study was conducted in eight parks in Lahore, Pakistan, over three years from 2011 to 2013.A total of 2,496 ovitraps were placed in environmentally different conditions near water channels, thick vegetation cover/shades, clean/unclean sites and places where there was lot of human activity.

Sero-surveillance of dengue in the city Lahore, Pakistan.

Objective: To conduct sero-surveillance of dengue cases, and to find out the demographic and socio-economic status of dengue patients.

Methods: This community-based, cross-sectional, descriptive study was conducted at the Institute of Public Health, Lahore, Pakistan, from July to December each year in 2011, 2012 and 2013, and comprised patients suspected to have dengue. Blood samples of dengue patients in five randomly selected union councils of the 10 towns of the city were subjected to the dengue test.

Predicting dengue outbreak in the metropolitan city Lahore, Pakistan, using dengue vector indices and selected climatological variables as predictors.

Objective: Dengue viruses have rapidly spread in Southeast Asia, particularly in Pakistan, during the last few years, so the present study was undertaken to formulate a model for predicting dengue outbreak.

Methodology: A panel data using STRATA statistical software was employed to determine the effects of entomological indices, Per Man Hour Density (PMHD), Minimum Infection Rate (MIR) and selected climatic variables on dengue patients by using Fixed Effects (FE) and Random Effects (RE) models.

Results: Results showed that R2 value, reflecting fitness of model was 0.

Dietary Exposure and Natural Occurrence of Total Aflatoxins in Basmati Rice of Pakistan.

This study presents the assessment of total aflatoxins (TAFs) in basmati rice (brown, 1,081; white, 1,170) collected from different areas of Punjab, Pakistan, during 2010 to 2015. Due to the carcinogenicity of TAFs, daily dietary exposure is also evaluated based on rice consumption survey data. Methodology was standardized by matrix spike recoveries at four fortification levels (0.