759 results match your criteria: "Gout and Pseudogout"
Polarised light scanner for digital pathology.
Virchows Arch
December 2024
Institute for Pathology, Sana Klinikum Lichtenberg, Berlin, Germany.
Digital pathology is rapidly transforming diagnostic pathology by allowing remote work and integration of artificial intelligence solutions. Nevertheless, certain technical issues remain to be resolved. Notably, digital images captured by conventional scanners cannot be subjected to polarised light analysis [1].
View Article and Find Full Text PDFTenosynovitis with psammomatous calcifications: Series of 18 cases and review of the literature emphasizing a common source of expert consultation and updated differential diagnosis.
Virchows Arch
December 2024
Department of Pathology, The Johns Hopkins University School of Medicine, 401 N Broadway, Weinberg Building 2245, Baltimore, MD, 21231, USA.
Article Synopsis
- - Tenosynovitis with psammomatous calcifications (TPC) is a rare, non-cancerous condition that often affects women and is thought to result from repetitive use or trauma, commonly appearing at sites like the hands, feet, and wrists.
- - In a study involving 18 new cases, most patients presented with painful masses, and imaging often showed benign characteristics, but many of these cases were misdiagnosed as more serious conditions like gout or tumors.
- - Follow-up on patients (mostly for around 30 months) showed no local recurrences after surgical removal, highlighting the necessity for greater awareness among medical professionals regarding TPC.
Development of a deep learning model for automated detection of calcium pyrophosphate deposition in hand radiographs.
Front Med (Lausanne)
October 2024
Department of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Article Synopsis
- CPPD disease is a significant cause of arthritis that can resemble other rheumatic conditions, making accurate diagnosis crucial.
- A deep-learning algorithm was developed and tested to automatically detect CPPD features in hand radiographs, focusing specifically on certain joint areas.
- The combined model for detecting CPPD showed strong performance metrics, with a mean AUROC of 0.86 and good sensitivity and specificity, while separate models for different joint areas had varying success rates.
[Calcium pyrophosphate deposition (CPPD) disease - more than just "pseudogout"].
Ther Umsch
September 2024
Universitätsklinik für Rheumatologie und Immunologie Freiburgstrasse, Anna-Seiler Haus, Stock J 3010 Bern.
Article Synopsis
- Calcium pyrophosphate deposition (CPPD) disease, often called "pseudogout," can be mistaken for gout but is a distinct condition in rheumatology.
- Unlike gout, CPPD cannot be cured and requires symptomatic treatment instead.
- The text reviews the pathophysiology, diagnosis, and current and emerging therapeutic approaches for managing CPPD.
Management of Bone Loss After Multiple Metacarpal and Distal Row Carpal Resection Due to Osteomyelitis.
Cureus
September 2024
Orthopedic Surgery, University of Arizona College of Medicine - Phoenix, Phoenix, USA.
Atraumatic wrist pain can be due to a variety of causes including gout, pseudogout, cellulitis, arthritis flare, or infection of the joint. One important differential to rule out immediately is septic arthritis as it is considered an orthopedic emergency. Due to the rarity of septic arthritis in the wrist, there is limited data to guide diagnosis and treatment.
View Article and Find Full Text PDFNew Developments in Imaging in Crystalline Arthritis.
Rheum Dis Clin North Am
November 2024
Department of Medicine, Allergy/Immunology & Rheumatology Division, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 695, Rochester, NY 14642, USA. Electronic address:
Article Synopsis
- * Traditional diagnosis relied on joint aspiration and microscopy, but imaging techniques are now preferred and can often suffice.
- * Recommended imaging methods include ultrasound, dual-energy CT scans, and regular X-rays, which can help locate inflammation and identify crystal deposits effectively.
Activation of osmo-sensitive LRRC8 anion channels in macrophages is important for micro-crystallin joint inflammation.
Nat Commun
September 2024
Université Paris Cité, INSERM UMR-1132, Bioscar, Hôpital Lariboisière, AP-HP, Paris, France.
Article Synopsis
- Monosodium urate (MSU) and calcium pyrophosphate (CPP) micro-crystals lead to inflammation in conditions like gout and chondrocalcinosis by activating macrophages, which release cytokines like IL-1β.
- The maturation of IL-1β is driven by the NLRP3 inflammasome, which gets activated in response to these crystals.
- This activation is dependent on the LRRC8 anion channels, as they help regulate cell volume and trigger ATP release, resulting in IL-1β maturation and inflammation, demonstrating their important role in joint inflammation from crystal deposits.
Tryptophanyl tRNA synthetase is an alternative synovial biomarker for diagnosis of septic arthritis in knee joint.
Knee Surg Relat Res
September 2024
Department of Orthopaedic Surgery, Gil Medical Center, Gachon University College of Medicine, Incheon, 21565, Republic of Korea.
Article Synopsis
- The study aims to assess tryptophanyl tRNA synthetase (WRS) as a diagnostic tool for septic arthritis of the knee, comparing its effectiveness to other biomarkers in distinguishing it from other forms of arthritis.* -
- A total of 62 patients with various arthritis types were analyzed, revealing that those with septic arthritis had significantly higher levels of WRS and other inflammatory markers, with WRS showing a high specificity (87.5%) and sensitivity (83.3%).* -
- The findings suggest WRS in synovial fluid could serve as a reliable biomarker for diagnosing septic arthritis, marking the need for further testing in separate patient groups.*
Selective Dissolution of Calcium Pyrophosphate Dihydrate Crystals Using a Pyrophosphate Specific Receptor.
Chembiochem
November 2024
Pharmacology and Pharmaceutical Sciences, University of Missouri-Kansas City School of Pharmacy, 2464 Charlotte St., Kansas City, MO, 64108.
Pseudo-gout is caused by the deposition of highly insoluble calcium pyrophosphate dihydrate (CPPD) crystals in the joints of sufferers. This leads to inflammation and ultimately joint damage. The insolubility of CPPD is driven by the strong attraction of di-cationic calcium ions with tetra-anionic pyrophosphate ions.
View Article and Find Full Text PDFCost Analysis of Routine Histopathologic Evaluation of Specimens Following Total Ankle Arthroplasty.
Foot Ankle Int
October 2024
Northwell, New Hyde Park, NY, USA.
Background: Routine histopathologic examination of orthopaedic surgical specimens is a standard practice at many institutions. Previous studies have demonstrated that this practice seldom altered patient management for several orthopaedic procedures. As a result, the value of such practices has come into question.
View Article and Find Full Text PDFCalcium pyrophosphate deposition disease.
Lancet Rheumatol
November 2024
Academic Rheumatology, University of Nottingham, Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham, UK.
Article Synopsis
- - Calcium pyrophosphate deposition disease (CPPD) occurs when CPP crystals build up in joints, triggering inflammation and arthritis, particularly in older individuals over 60, and is linked to cartilage deterioration and osteoarthritis.
- - Common risk factors for CPPD include aging, past joint injuries, and certain metabolic conditions or genetic factors. Diagnosis relies on detecting CPP crystals in joint fluid and imaging techniques like X-rays and ultrasound.
- - Current treatment focuses on managing inflammation since there’s no cure for dissolving CPP crystals; options include prednisone for acute arthritis, low-dose colchicine, and potential use of biologics for stubborn cases.
Features Associated With Different Inflammatory Phenotypes of Calcium Pyrophosphate Deposition Disease: A Study Using Data From the International American College of Rheumatology/EULAR Calcium Pyrophosphate Deposition Classification Criteria Cohort.
Arthritis Rheumatol
December 2024
University of Nottingham, Nottingham, United Kingdom.
Article Synopsis
- The study aimed to analyze the disease, demographic, and imaging characteristics linked to different types of calcium pyrophosphate deposition (CPPD) disease, focusing on recurrent acute CPP crystal arthritis, chronic CPP crystal inflammatory arthritis, and crowned dens syndrome (CDS).
- Researchers utilized data from an international cohort of 618 individuals to investigate the phenotypic traits of each type of CPPD and performed multivariable logistic regression to assess associations between risk factors and inflammatory phenotypes.
- Key findings indicated that longer disease duration correlated with recurrent acute arthritis, while chronic arthritis was linked to specific joint issues and less associated with metabolic risks, and CDS was more common in males with greater joint involvement. *
Predicting Septic Arthritis in the Setting of Crystalline Arthropathy in the Native Joint Using Laboratory Data.
Iowa Orthop J
June 2024
Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Article Synopsis
- Septic arthritis is a serious condition that can be tricky to diagnose, especially when a patient also has crystal arthritis like gout or pseudogout, as their symptoms are quite similar.
- Diagnosis usually involves analyzing synovial fluid through arthrocentesis, but the presence of crystals does not exclude the possibility of septic arthritis, which is confirmed through positive cultures.
- A study found that higher total nucleated cell counts (TNC), elevated CRP levels, and a higher percentage of polymorphonuclear cells significantly increase the likelihood of a positive culture for septic arthritis, particularly in females.
Anakinra for Refractory Pseudogout in Patients with End-stage Renal Disease on Haemodialysis.
Mediterr J Rheumatol
March 2024
First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Article Synopsis
- CPPD arthritis is the second most common crystal-induced arthritis after gout and is typically treated with non-steroidal anti-inflammatory drugs or glucocorticoids.
- There is currently no effective pharmacological treatment to reduce CPPD crystal levels, making it hard to manage in chronic cases, especially for patients with end-stage renal disease.
- A study found that treating two patients with chronic CPPD arthritis and end-stage renal disease with the IL-1β receptor antagonist anakinra led to quick resolution of symptoms and allowed them to stop glucocorticoids, suggesting it may be a safe and effective treatment option.
Systematic literature review to inform the EULAR recommendations for the use of imaging in crystal-induced arthropathies in clinical practice.
Ann Rheum Dis
August 2024
Department of Rheumatology, University Hospital La Paz, IdiPaz, Madrid, Spain
Article Synopsis
Describing calcium pyrophosphate deposition: undoing the tower of Babel!
Curr Opin Rheumatol
May 2024
IRCCS Ospedale Galeazzi - Sant'Ambrogio, Rheumatology Department, Milan, Italy.
Purpose Of Review: In 1977, McCarty astutely observed, 'The variety of names suggested for the condition associated with deposits of calcium pyrophosphate dihydrate crystals is exceeded only by the variations of its clinical presentation'. Fast forward to 2024, a standardized nomenclature for calcium pyrophosphate deposition (CPPD) is still lacking. This review aims to delineate the challenges in characterizing CPPD through nomenclature and imaging.
View Article and Find Full Text PDFMiddle Ear Tophi: A Case Series of Two Unusual Lesions and a Report of Facial Weakness and Review of the Literature.
Otol Neurotol
April 2024
Department of Otolaryngology-Head and Neck Surgery, San Antonio Uniformed Services Health Education Consortium, JBSA-Fort Sam Houston, Texas.
Objective: Tophaceous lesions of the middle ear from calcium pyrophosphate deposition disease (CPPD, or pseudogout) and gout are infrequently reported. Recognizing its characteristic findings will allow clinicians to accurately narrow the differential diagnosis of bony-appearing middle ear lesions and improve management.
Patients: Two consecutive cases of tophaceous middle ear lesions presenting to a tertiary care center between January 2021 and December 2021.
2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice.
Ann Rheum Dis
May 2024
Rheumatology, IRCCS Ospedale Galeazzi-Sant'Ambrogio, Milan, Italy.
Article Synopsis
Safety and efficacy of colchicine in crystal-induced arthritis flare in 54 patients with severe chronic kidney disease.
RMD Open
January 2024
Service de Rhumatologie de Hautepierre, RESO, Centre de Référence des Maladies Autoimmunes Systémiques Rares Est Sud-Ouest, Hôpitaux universitaires de Strasbourg, Strasbourg, France
Introduction: Colchicine, commonly used in gout flare, is contraindicated in severe chronic kidney disease (CKD) (estimated glomerular filtration rate <30 mL/min). However, in this context, there are few alternatives, and colchicine use persists. We evaluated the tolerance of colchicine and its efficacy in patients with severe CKD.
View Article and Find Full Text PDFUltrasound imaging in crystal arthropathies: a pictorial review.
Reumatismo
December 2023
Department of Rheumatology, Galeazzi - Sant'Ambrogio IRCCS Hospital, Milan.
Objective: The prevalence of crystal arthropathies in the general population is rising. The purpose of this pictorial study is to describe the sonographic elements of the most prevalent crystal arthropathies by emphasizing particular sonographic findings using illustrative images and cases while considering technical details and common pitfalls.
Methods: Using established recommendations, specialists in the fields of sonography and crystal arthropathies agreed by consensus on the unique ultrasound signs associated with each of the conditions.
Non-loading versus loading low-dose colchicine in acute crystal-associated arthritis: A double-blinded randomized controlled study.
Int J Rheum Dis
December 2023
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Introduction: This study aimed to compare the efficacy of non-loading versus loading low-dose colchicine in patients with acute crystal-associated arthritis.
Materials And Methods: All in-patients who were admitted to Chiang Mai University Hospital with non-arthritis disease and developed acute crystal-associated arthritis during admission (within 48 h after arthritis onset) were invited to join this study. The patients were randomized into two groups.
Crystal Diseases of the Spine.
Semin Musculoskelet Radiol
October 2023
CHU Lille, Service de Radiologie et Imagerie Musculosquelettique, Lille, France.
Gout, calcium pyrophosphate deposition disease, and apatite calcifications, the three main crystal disorders, may involve the spine. These disorders can be completely asymptomatic or associated with various clinical symptoms, such as acute flares and more chronic manifestations. This article presents the typical and more unusual imaging features encountered in these disorders.
View Article and Find Full Text PDFJoint manifestations revealing inborn metabolic diseases in adults: a narrative review.
Orphanet J Rare Dis
August 2023
Department of Internal Medicine, University Hospital of Tours, Tours, France.
Inborn metabolic diseases (IMD) are rare conditions that can be diagnosed during adulthood. Patients with IMD may have joint symptoms and the challenge is to establish an early diagnosis in order to institute appropriate treatment and prevent irreversible damage. This review describes the joint manifestations of IMD that may be encountered in adults.
View Article and Find Full Text PDF