[Ultrasound-guided synovial biopsy].

A 47-year-old female presented with arthritis in the left hand's PIP III. Her symptoms were negative for connective tissue disease or spondyloarthritis, but she had HIV and hepatitis B. Initial tests showed no systemic inflammation or abnormal antibodies, and radiology revealed no bony changes.

Ultrasonographic Evaluation of Urate Crystal Deposition in Tendons With Gout Patients.

Objective: To use ultrasound technology to assess the deposition of urate crystals in the common lower limb tendons of patients with gout, providing additional imaging information for the management of these patients.

Methods: High-frequency ultrasound was retrospectively used to evaluate urate crystal deposition in common lower limb tendons-quadriceps, patellar, and Achilles-in patients with gouty arthritis. Comparative statistical analysis was conducted among asymptomatic hyperuricemia patients and healthy individuals during the same period.

Optimized vector for functional expression of the human bitter taste receptor TAS2R14 in HEK293 cells.

Bitter is one of the five basic taste qualities, along with salty, sour, sweet and umami, used by mammals to access the quality of their food and orient their eating behaviour. Bitter taste detection prevents the ingestion of food potentially contaminated by bitter-tasting toxins. Bitter taste perception is mediated by a family of G protein-coupled receptors (GPCRs) called TAS2Rs.

A 6-year-old girl with gout: a case report and another unusual presentation.

Background: Gout is the most common inflammatory arthritis in adults, and although gout has been trending younger in recent years, children with gout before the age of 10 years are still rare cases, especially asymptomatic children with gout, making gout in children easy to misdiagnose. This study aimed to describe the clinical characteristics, laboratory tests, imaging findings, and treatment outcomes of a 6-year-old girl with gout.

Case Description: This case presents a detailed report of a 6-year-old girl diagnosed with primary gout, a condition that is exceedingly rare in pediatric patients, especially those asymptomatic.

Polarised light scanner for digital pathology.

Digital pathology is rapidly transforming diagnostic pathology by allowing remote work and integration of artificial intelligence solutions. Nevertheless, certain technical issues remain to be resolved. Notably, digital images captured by conventional scanners cannot be subjected to polarised light analysis [1].

Preclinical gout is common in the patient with stage 3-5 chronic kidney disease. Relevance of musculoskeletal ultrasound.

Background: One in 10 patients with hyperuricemia may develop gout over time, with urate deposition sometimes asymptomatic. Recent reviews and guidelines support ultrasound (US) to assess asymptomatic hyperuricemic (AH) patients to detect gout lesions, showing double contour (DC) and tophus the highest specificities and positive predictive values. Hyperuricemia and gout are common in chronic kidney disease (CKD), especially with glomerular filtration rate (GFR) <60, and both are associated with worse prognosis, although treatment of AH in CKD is not yet recommended in all guidelines.

A Mathematical Model for Wind Velocity Field Reconstruction and Visualization Taking into Account the Topography Influence.

In this paper, we propose a global modelling for vector field approximation from a given finite set of vectors (corresponding to the wind velocity field or marine currents). In the modelling, we propose using the minimization on a Hilbert space of an energy functional that includes a fidelity criterion to the data and a smoothing term. We discretize the continuous problem using a finite elements method.

An observational study of ultrasound semiquantitative scoring for predicting the risk of gout flare.

Objective: An observational study was conducted to determine whether semiquantitative scoring of ultrasound signs of gout predicted flare over 12 months.

Methods: Gout patients were enrolled consecutively in this 12-month prospective observational single-center study. Ultrasound evaluation and clinical assessment were performed at baseline.

Enhancing Gout Diagnosis with Deep Learning in Dual-energy Computed Tomography: A Retrospective Analysis of Crystal and Artifact Differentiation.

Objectives: To evaluate whether the application of deep learning (DL) could achieve high diagnostic accuracy in differentiating between green colour coding, indicative of tophi, and clumpy artifacts observed in dual-energy computed tomography (DECT) scans.

Methods: A comprehensive analysis of 18 704 regions of interest (ROIs) extracted from green foci in DECT scans obtained from 47 patients with gout and 27 gout-free controls was performed. The ROIs were categorized into three size groups: small, medium, and large.

Performance of novel multiparametric second-generation dual-layer spectral detector CT in gouty arthritis.

Objectives: This study aimed to compare the performance of different dual-energy computed tomography (DECT) technologies in detecting monosodium urate (MSU) crystals and evaluate the potential clinical value of novel second-generation dual-layer spectral detector CT (dlDECT) in gouty arthritis.

Methods: Using data collected from a tertiary hospital, we examined the diagnostic accuracy of different DECT technologies for the diagnosis of MSU. We used two standards: (1) demonstration of MSU crystals in synovial fluid (gold) and (2) 2015 ACR/EULAR gout classification criteria (silver).

Imaging methods in monitoring gout - a pictorial essay.

We present a pictorial essay based on the case of a 52-year-old man suffering from chronic gout, who was followed up for seven years. During this period of time, radiographs, ultrasonography, and dualenergy computed tomography were performed several times, revealing severe progression of gout. This was most likely due to the lack of patient compliance.

Material decomposition approaches for monosodium urate (MSU) quantification in gouty arthritis: a (bio)phantom study.

Background: Dual-energy computed tomography (DECT) is a noninvasive diagnostic tool for gouty arthritis. This study aimed to compare two postprocessing techniques for monosodium urate (MSU) detection: conventional two-material decomposition and material map-based decomposition.

Methods: A raster phantom and an ex vivo biophantom, embedded with four different MSU concentrations, were scanned in two high-end CT scanners.

[Gout - clinical presentation].

Gout is a common form of inflammation, characterized by sudden, severe attacks of pain, swelling, redness and tenderness. The diagnosis is based on the typical clinical pattern, but the definitive diagnosis requires the identification of urat crystals in the joint fluid or in ultrasound or DECT. The differential diagnosis includes always infection or other crystal arthropathies, in atypical presentation also other forms of arthritis, e.

Hyperuricemia suppresses lumican, exacerbating adverse remodeling after myocardial infarction by promoting fibroblast phenotype transition.

Background: Hyperuricemia is independently associated with a poor prognosis in patients with myocardial infarction (MI). Furthermore, MI induces activation of the repair response in local fibroblasts, resulting in extracellular matrix accumulation that generates a stable fibrotic scar in the infarcted area. However, researchers have not determined whether hyperuricemia affects fibroblast activation and its involvement in postinfarction cardiac remodeling.