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Development of an oxazole-based cleavable linker for peptides.
Bioorg Med Chem
March 2024
Department of Chemistry, University of Richmond, Gottwald Science Center B-100 138 UR Drive University of Richmond, VA 23173, United States. Electronic address:
We report the development of a new oxazole-based cleavable linker to release peptides from attached cargo. Oxazoles are stable to most reaction conditions, yet they can be rapidly cleaved in the presence of single-electron oxidants like cerium ammonium nitrate (CAN). An oxazole linker could be synthesized and attached to peptides through standard solid-phase peptide coupling reactions.
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