Investigating the effects of remdesivir on corrected QT interval in patients with severe COVID-19 disease: a historical cohort study.

Background: There is little information about the risk of drug-induced QT prolongation by remdesivir as the most important FDA approved anti COVID-19 drug. Prolongation of corrected QT interval (QTc) is considered as an indicator of an unfavorable outcome which may ultimately induce torsade de pointes and provoke ventricular fibrillation. The aim of this study was to determine the effects of remdesivir on QTc in patients with severe COVID 19 disease.

Combination of Serologic Tests and Sputum Culture Results as the Best Diagnostic Method of Infection in Cystic Fibrosis Patients.

Background: One of the most common reasons for mortality in patients with cystic fibrosis (CF) is lung infections, among which () infection has the largest share. Diagnosis of can be assessed by various methods such as sputum culture results and IgG antibody level via measuring the specific anti- antibodies. This study aimed to select the best predictive technique in the diagnosis of in CF patients through spirometry, sputum culture, and serum IgG antibody levels.

The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity.

Coronavirus Disease 2019 [COVID-19], caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], has rapidly evolved into a global health emergency. Neopterin [NPT], produced by macrophages when stimulated with interferon [IFN-]gamma, is an essential cytokine in the antiviral immune response. NPT has been used as a marker for the early assessment of disease severity in different diseases.

Outcomes of Temporary Hemi-Epiphysiodesis Using a New Device for The Treatment of Pediatric Valgus Knee Deformity: a Preliminary Report.

Background: This study aimed to evaluate the efficacy of hemi-epiphysiodesis using a new device (X-plate) for the correction of genu valgum.

Methods: In total, 22 children with a total of 34 pathologic knee valgus deformities underwent the procedure and were followed up 25.3 months on average.

COVID-19 in Children with Congenital Heart Diseases: A Multicenter Case Series from Iran.

Background: Promptly discovering and counteracting COVID-19 is critical as it could have catastrophic effects. As an asymptomatic group, children are highly susceptible to be misdiagnosed, especially those suffering from underlying diseases. Furthermore, discriminating the direct effects of the virus from those of the underlying diseases can pose a dilemma to physicians.

Bidirectional association between COVID-19 and the environment: A systematic review.

The global crisis caused by SARS-CoV-2 (COVID-19) affected economics, social affairs, and the environment, not to mention public health. It is estimated that near 82% of the SARS-CoV-2 genome is similar to the severe acute respiratory syndrome. The purpose of the review is to highlight how the virus is impacted by the environment and how the virus has impacted the environment.

Role of the potassium channels in vasorelaxant effect of asafoetida essential oil.

Objective: In a previous work, we showed that asafoetida essential oil (AEO), from oleo-gum resin of L. from the Apiaceae family, has a vasodilatory effect. This effect was both endothelium-dependent and endothelium-independent.

Bioavailability of rectal acetaminophen in children following anorectal surgery.

Background: Acetaminophen is widely used as an analgesic and antipyretic agent in pediatrics. Although bioavailability of rectal acetaminophen is unpredictable, rectal route is a usual and acceptable method of prescription. Major anorectal surgery may alter the normal structure of the surgical site, especially the vascular elements and the normal connections between port and systemic vessels.

Pre-operative hormone stimulation in hypospadias repair: A facilitator or a confounder.

Introduction: Preoperative hormone stimulation (PHS) is popular in hypospadias reconstructive surgery. While still controversial, it is performed to have a more developed gross anatomy of the glans and penis for improvement of the surgical condition and outcome.

Objective: In this study we assessed morphometric and histologic effects of pre-operative testosterone therapy on the penis and prepuce in patients with hypospadias.

microRNAs involved in T-cell development, selection, activation, and hemostasis.

MicroRNAs (miRNAs) characterized by small, noncoding RNAs have a fundamental role in the regulation of gene expression at the post-transcriptional level. Additionally, miRNAs have recently been identified as potential regulators of various genes involved in the pathogenesis of the autoimmune and inflammatory disease. So far, the interaction between miRNAs and T lymphocytes in the immune response as a new and significant topic has not been emphasized substantially.

17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines.

Aging effects in energy balance in all tissues and organs, including the cardiovascular. The risk of cardiovascular disease is drastically higher in postmenopausal women than in premenopausal women. Estrogen plays an important role in the cardiac function and body's metabolism.

Antifungal Activity of ZnO Nanoparticles and Nystatin and Downregulation of SAP1-3 Genes Expression in Fluconazole-Resistant Isolates from Vulvovaginal Candidiasis.

Purpose: Antifungal resistance and virulence properties of ( are growing health problems worldwide. The present study aims to investigate the effect of Zinc Oxide (ZnO) nanoparticles and Nystatin on SAP1-3 genes expression in isolates of females with Vulvovaginal Candidiasis (VVC) isolated from Sayad Shirazi Obstetrics and Gynecology Hospital in Northeastern Iran during 2017-2018.

Patients And Methods: In this descriptive-analytic study, vaginal samples were collected from 280 VVC women.

The Effect of Education on Blind Women's Empowerment in Reproductive Health: a Quasi-experimental Survey.

As blind women have usually been known as a group at risk, they should be necessarily considered to a larger extent in health consulting programs. Therefore, the present survey was aimed to investigate blind women empowerment toward sexual and reproductive health care. A quasi-experimental study was conducted on all 26 blind women covered by the Blind Society in the Azerbaijan province.

Zinc Oxide Nanoparticles Inhibition of Initial Adhesion and ALS1 and ALS3 Gene Expression in Candida albicans Strains from Urinary Tract Infections.

Objective: The aim of this study was to evaluate effects of zinc oxide nanoparticles (ZnO-np) on initiation adhesion and agglutinin-like sequence (ALS) 1 and ALS3 gene expression, which is the first cell surface protein known to be, required for biofilm formation in 125 Candida albicans (C. albicans) from urinary tract infections (UTIs).

Methods: In this descriptive-analytic study, Candida UTIs was cultured from 280 women admitted in hospital Sayad Shirazi, in Northeastern Iran in the 2018 year.

Interaction between stewardship and social health insurances: A comparative and document analysis.

Social health insurances provide protection to access affordable coverage of services and stewardships of health system need to intervene to fulfill these objectives. This study conducted to assess interaction between stewardship and social health insurances. This qualitative study conducted in two phases as comparative study and document analysis in 2018.

The effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat hearts.

Objective: Previous studies reported that asafetida from Linn. species and its essential oil (AEO) have antioxidant effects. In the present study, the effect of AEO was evaluated on ischemic-reperfusion injury in isolated rat hearts.

Investigation of the Effect of Hypnotic Anesthesia on Nerve Conduction Velocity (NCV).

Background: Hypnosis is a psychological method used for treatment of different types of disorders and illnesses. This technique is also used in surgical interventions. Many studies proved the efficacy of hypnosis in medical treatment.

Best Practice for Prolonged Fever in Primary Care Setting: Close Follow-Up or Empiric Antibiotic Therapy?

The management of prolonged fever in low-socioeconomic-status areas by primary care providers such as general practitioners is challenging. Given the endemic nature of many infectious diseases, physicians typically start empirical antibiotic therapy following a limited diagnostic workup including serologic examinations. Herein, we report the case of a young male patient with prolonged fever and arthralgia initially diagnosed with and treated for brucellosis but with a confirmed diagnosis of systemic lupus erythematosus on follow-up.

Bullous Fixed Drug Eruption Following Ibuprofen Ingestion.

Fixed drug eruption (FDE) is a drug reaction involving skin and less commonly mucosal membranes. The common manifestation is localized well-demarcated patches or plaques appeared following receiving of a culprit drug. When re-exposure occurs, the rashes will appear at areas involved in previous episodes.

Vasodilatory effect of asafoetida essential oil on rat aorta rings: The role of nitric oxide, prostacyclin, and calcium channels.

Background: Asafoetida is an oleo-gum resin mainly obtained from Ferula assa-foetida L. species in the apiaceae family. Previous studies have shown that it has antispasmodic effects on rat's and pig's ileums.

Frequency and Risk Factors of Penicillin and Amoxicillin Allergy in Suspected Patients with Drug Allergy.

Background: Unconfirmed beta-lactam allergy is a significant public health problem because of the limitations it imposes in drug selection. In this study, we aimed to evaluate patients referred for beta-lactam allergy to determine the frequency of confirmed beta-lactam allergy and identify some risk factors.

Methods: In a prospective cohort study, all referred patients to Immunology, Asthma and Allergy Research Institute in Tehran University of Medical Sciences (between 2007 - 2009) who suspected to have beta-lactam allergy were entered into this study based on having the inclusion criteria.

AZDAST the new horizon in antimicrobial synergism detection.

The attempts via introducing many methods have been conducted to select the best antibiotic combination in the treatment of seriously ill patients. Operational or interpretational complexity or time-consuming along with sufficient accuracy led to postpone routine clinical use of these tests until today, despite the urgent need for them. By this study and proposed method, selection of the best double antibiotic synergistic combination against resistant pathogen is simply same as Kirby-Bauer antibiotic susceptibility test.

CD20-targeting in B-cell malignancies: novel prospects for antibodies and combination therapies.

Expression of CD20 antigen by the most of transformed B cells is believed to be the driving force for targeting this molecule by using anti-CD20 monoclonal antibodies. While it is true that most lymphoma/leukemia patients can be cured, these regimens are limited by the emergence of treatment resistance. Based on these observations, development of anti-CD20 monoclonal antibodies and combination therapies have been recently proposed, in particular with the aim to optimize the cytotoxic activity.

Involvement of Mu Opioid Receptor Signaling in the Protective Effect of Opioid against 6-Hydroxydopamine-Induced SH-SY5Y Human Neuroblastoma Cells Apoptosis.

Introduction: The neuroprotective role of opioid morphine against 6-hydroxydopamine-induced cell death has been demonstrated. However, the exact mechanism(s) underlying such neuroprotection, especially the role of subtype receptors, has not yet been fully clarified.

Methods: Here, we investigated the effects of different opioid agonists on 6-OHDA-induced neurotoxicity in human neuroblastoma SH-SY5Y cell line as an in vitro model of Parkinson's disease.

STAT3 is Overactivated in Gastric Cancer Stem-Like Cells.

Objective: Gastric cancer (GC) is widely associated with chronic inflammation. The pro inflammatory microenvironment provides conditions that disrupt stem/progenitor cell proliferation and differentiation. The signal transducer and activator of transcrip- tion-3 (STAT3) signaling pathway is involved in inflammation and also contributes to the maintenance of embryonic stem cell (ESCs) pluripotency.