258 results match your criteria: "Gonda Brain Research Center[Affiliation]"

Common ground (CG)-a pragmatic capability that reflects the construction of shared meaning by two interlocutors during conversation-is widely accepted as crucial for effective communication, but its exploration has been limited in the context of children's peer-to-peer interaction. Specifically, this study aimed to explore CG differences between typically developing (TD) and autistic populations, CG's developmental trajectories, as well as the link between CG and motor coordination skills during peer interactions. Study participants included 148 children (6-16 years), comparing 64 TD and 84 autistic children across three age levels.

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New Vistas for the Relationship between Empathy and Political Ideology.

eNeuro

November 2024

Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo 02150, Finland

The study of ideological asymmetries in empathy has consistently yielded inconclusive findings. Yet, until recently these inconsistencies relied exclusively on self-reports, which are known to be prone to biases and inaccuracies when evaluating empathy levels. Very recently, we reported ideological asymmetries in cognitive-affective empathy while relying on neuroimaging for the first time to address this question.

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Article Synopsis
  • Metastatic disease is a major cause of cancer-related deaths, yet its tumor microenvironment is not well understood due to technical challenges in studying it.
  • This research created a comprehensive map of 67 tumor biopsies from 60 metastatic breast cancer patients, using advanced techniques like single-cell RNA sequencing and various spatial expression assays to analyze tumor characteristics.
  • Key findings included identifying different macrophage spatial patterns, three phenotypes of epithelial-to-mesenchymal transition, and gene expression linked to T cell presence or absence, highlighting the study's potential for clinical insights.
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The Body Knows Better: Sensorimotor signals reveal the interplay between implicit and explicit Sense of Agency in the human mind.

Cognition

January 2025

School of Psychological Sciences, University of Haifa, Haifa, Israel; Department of Cognitive Sciences University of Haifa, Haifa, Israel; The Integrated Brain and Behavior Research Center (IBBRC), University of Haifa, Haifa, Israel. Electronic address:

Sense of Agency (SoA) is the feeling of control over our actions. SoA has been suggested to arise from both implicit sensorimotor integration as well as higher-level decision processes. SoA is typically measured by collecting participants' subjective judgments, conflating both implicit and explicit processing.

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Caregiving plays a critical role in children's cognitive, emotional, and psychological well-being. In the current longitudinal study, we investigated the enduring effects of early maternal behavior on processes of interbrain synchrony in adolescence. Mother-infant naturalistic interactions were filmed when infants were 3-4 months old and interactions were coded for maternal sensitivity and intrusiveness with the Coding Interactive Behavior Manual.

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Article Synopsis
  • Psychological interventions can effectively alter mental perspectives, particularly in the context of intergroup conflicts, by addressing negative attitudes toward outgroups.
  • The study utilized magnetoencephalography to objectively measure changes in neural alignment before and after a paradoxical thinking intervention, focusing on auditory narratives related to the Israeli-Palestinian conflict.
  • Results showed significant increased neural alignment in participants after the intervention, suggesting a potential shift in mental perspective, highlighting the importance of neuroimaging in assessing the effectiveness of such interventions.
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Disfluencies as a Window into Pragmatic Skills in Russian-Hebrew Bilingual Autistic and Non-Autistic Children.

J Autism Dev Disord

September 2024

The Department of English Literature and Linguistics and the Gonda Brain Research Center, Bar-Ilan University, Ramat Gan, 5290002, Israel.

There is little research on the production of speech disfluencies such as silent pauses, repetitions, self-corrections, and filled pauses (e.g., eh, em) in monolingual autistic children, and there is no data on this crucial part of speech production in bilingual autistic children.

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Single-trial detection of auditory cues from the rat brain using memristors.

Sci Adv

September 2024

Centre for Electronics Frontiers, Institute for Integrated Micro and Nano Systems, School of Engineering, The University of Edinburgh, Edinburgh, UK.

Implantable devices hold the potential to address conditions currently lacking effective treatments, such as drug-resistant neural impairments and prosthetic control. Medical devices need to be biologically compatible while providing enhanced performance metrics of low-power consumption, high accuracy, small size, and minimal latency to enable ongoing intervention in brain function. Here, we demonstrate a memristor-based processing system for single-trial detection of behaviorally meaningful brain signals within a timeframe that supports real-time closed-loop intervention.

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Case Conceptualization in Clinical Practice and Training.

Clin Psychol Eur

April 2024

Department of Psychology and the Gonda Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel.

Case conceptualization is central to the success of the therapeutic process. However, integrative case conceptualization research has lagged behind research on integrating therapeutic intervention techniques. A successful case conceptualization provides (a) a dynamic, context-sensitive, yet parsimonious model of the client's functioning; (b) relevant treatment targets and associated assessment procedures; and (c) a treatment plan including intervention phases and potential obstacles.

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Can repetitive mechanical motion cause structural damage to axons?

Front Mol Neurosci

June 2024

Faculty of Engineering, Bar Ilan Institute of Nanotechnologies and Advanced Materials, Gonda Brain Research Center, Bar Ilan University, Ramat Gan, Israel.

Biological structures have evolved to very efficiently generate, transmit, and withstand mechanical forces. These biological examples have inspired mechanical engineers for centuries and led to the development of critical insights and concepts. However, progress in mechanical engineering also raises new questions about biological structures.

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Major depressive disorder (MDD) stands as a significant cause of disability globally. Cannabidiolic Acid-Methyl Ester (CBDA-ME) (EPM-301, HU-580), a derivative of Cannabidiol, demonstrates immediate antidepressant-like effects, yet it has undergone only minimal evaluation in psychopharmacology. Our goal was to investigate the behavioral and potential molecular mechanisms associated with the chronic oral administration of this compound in the Wistar Kyoto (WKY) genetic model of treatment-resistant depression.

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Many people, and particularly individuals with Attention Deficit (Hyperactivity) Disorder (AD(H)D), find it difficult to maintain attention during classroom learning. However, traditional paradigms used to evaluate attention do not capture the complexity and dynamic nature of real-life classrooms. Using a novel Virtual Reality platform, coupled with measurement of neural activity, eye-gaze and skin conductance, here we studied the neurophysiological manifestations of attention and distractibility, under realistic learning conditions.

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Timely goal-oriented behavior is essential for survival and is shaped by experience. In this paper, a multileveled approach was employed, ranging from the polymorphic level through thermodynamic molecular, cellular, intracellular, extracellular, non-neuronal organelles and electrophysiological waves, attesting for signal variability. By adopting Boltzmann's theorem as a thermodynamic conceptualization of brain work, we found deviations from excitation-inhibition balance and wave decoupling, leading to wider signal variability in affective disorders compared to healthy individuals.

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Article Synopsis
  • Parenting a child with a chronic illness involves various challenges but can also lead to personal growth, known as post-traumatic growth (PTG).
  • A systematic review of 34 studies with over 5,000 parents found that PTG was common among these parents, but it was not linked to psychological distress.
  • The analysis showed that PTG was positively associated with social support and resilience, especially in parents of children with psychiatric illnesses, highlighting the need for awareness of these factors in clinical settings.
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Mother-infant interactions form a strong basis for emotion regulation development in infants. These interactions can be affected by various factors, including maternal postnatal anxiety. Electroencephalography (EEG) hyperscanning allows for simultaneous assessment of mother-infant brain-to-behavior association during stressful events, such as the still-face paradigm (SFP).

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Texting has become one of the most prevalent ways to interact socially, particularly among youth; however, the effects of text messaging on social brain functioning are unknown. Guided by the biobehavioral synchrony frame, this pre-registered study utilized hyperscanning EEG to evaluate interbrain synchrony during face-to-face versus texting interactions. Participants included 65 mother-adolescent dyads observed during face-to-face conversation compared to texting from different rooms.

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Skin epidermal keratinocyte p53 induces food uptake upon UV exposure.

Front Behav Neurosci

December 2023

Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Article Synopsis
  • The study examines how UVB radiation affects appetite stimulation through the activation of the p53 protein in epidermal keratinocytes, the skin's primary cells.
  • Findings suggest that daily exposure to UVB increases food intake in mice, dependent on the presence of p53, with mice lacking p53 showing reduced appetite.
  • The research highlights the role of p53 in producing β-endorphin, linking UVB exposure to changes in appetite and anxiety behaviors, which may have potential implications for treating related disorders.
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This Special Issue represents a continuation of our previous Special Issue entitled "Endocannabinoids, Cannabinoids and Psychiatry: Biological Mechanisms" [...

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Background: The debate regarding diagnostic classification systems in psychiatry (categorial dimensional systems) has essential implications for the diagnosis, prevention and treatment of stress reactions. We previously found a unique pattern of stress reaction in a study executed during the coronavirus disease 2019 pandemic using large representative samples in two countries, and termed it the Complex Stress Reaction Syndrome (CSRS).

Aim: To investigate CSRS, Type A (psychiatric symptoms, spanning anxiety, depression, stress symptoms, and post-traumatic stress disorder (PTSD)), with or without long-coronavirus disease (COVID) residuals (CSRS, Type B, neuropsychiatric symptoms spanning cognitive deficits and fatigue, excluding systemic symptoms).

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Background: Deep-learning is widely used for lesion classification. However, in the clinic patient data often has missing images.

Purpose: To evaluate the use of generated, duplicate and empty(black) images for replacing missing MRI data in AI brain tumor classification tasks.

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In a birth, death, and diffusion process, the extinction-survival transition occurs when the average net growth rate is zero. For instance, in the presence of normally distributed time-varying stochastic growth rates with no autocorrelation, the transition indeed occurs at zero net growth rates. In contrast, if the growth rates are constant in time, a large enough variance in the growth rate will systematically ensure the survival of the global population even in a small system and, more importantly, even with a negative net growth rate.

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Spectral and phase-coherence correlates of impaired auditory mismatch negativity (MMN) in schizophrenia: A MEG study.

Schizophr Res

November 2023

Department of Child and Adolescent Psychiatry, Charité-Universitätsmedizin Berlin, Augustenburgerplatz 1, 13353 Berlin, Germany; Institute of Neuroscience and Psychology, University of Glasgow, 58 Hillhead Street, G12 8QB Glasgow, Scotland, United Kingdom of Great Britain and Northern Ireland. Electronic address:

Background: Reduced auditory mismatch negativity (MMN) is robustly impaired in schizophrenia. However, mechanisms underlying dysfunctional MMN generation remain incompletely understood. This study aimed to examine the role of evoked spectral power and phase-coherence towards deviance detection and its impairments in schizophrenia.

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Cognitive control, which has been localized to the right inferior frontal gyrus (rIFG) based on functional imaging and brain lesion studies, is impaired in patients with ADHD. The present study aims to investigate whether transcranial direct current stimulation (tDCS) over the rIFG might improve cognitive control in ADHD subjects. We hypothesized poorer performance in a cognitive control task, but not in a control language task, in the ADHD subjects.

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Priming group identities affects children's resource distribution among groups.

Child Dev

March 2024

Department of Psychology and Gonda Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel.

The present research investigated the effect of ethnic-national identity on intergroup attitudes among Israeli children. Between 2019 and 2020, 136 Arab Muslim and 136 Jewish 5- and 10-year-olds (boys and girls) participated in one of four ethnic-national identity conditions: ingroup, outgroup, common identity, and control. In each condition, participants were described a city whose residents were defined according to the condition.

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