851 results match your criteria: "Gonadotropin-Releasing Hormone Deficiency in Adults"
Luteinizing hormone profiles during ovarian stimulation in assisted reproductive treatment.
Front Endocrinol (Lausanne)
December 2024
Leuven University Fertility Center, Department of Gynecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium.
Introduction: Few data is available on the natural course of luteinizing hormone (LH) during ovarian stimulation, but it has been suggested that 'oversuppressed' LH could decrease fertility outcomes. Our aim with this study is to evaluate the changes in LH depending on the used stimulation protocol to better define LH oversuppressioin.
Methods: Patients undergoing oocyte retrieval in a tertiary fertility center between 01-01-2015 and 30-09-2020 after stimulation with a short-agonist (SA) or antagonist (A) protocol were included.
Dual trigger or hCG alone: A retrospective analysis on patients with diminished ovarian reserve under in vitro fertilization and embryo transfer (IVF-ET) treatment.
Eur J Obstet Gynecol Reprod Biol
November 2024
Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China. Electronic address:
Article Synopsis
- The study looked at how effective two different methods of triggering ovulation are for women with fewer eggs (DOR) during in vitro fertilization (IVF).
- Researchers compared a dual-trigger method (using two medications) to a single method (using just one medication) to see if it made any difference in getting better results.
- The results showed that using both methods didn't provide any better outcomes for getting eggs or successful pregnancies than just using the single method alone.
Diagnosis of Kallmann Syndrome in a Young Adult Male.
Cureus
August 2024
Radiodiagnosis, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth,Pimpri, Pune, IND.
Article Synopsis
- * A young adult male with anosmia since childhood exhibited signs of incomplete sexual development and underwent imaging tests, which revealed missing olfactory bulbs and small testes.
- * The MRI played a key role in diagnosing Kallmann syndrome by showing typical brain and hormonal characteristics, while the anterior pituitary appeared normal.
Disorder-Not CHARGE Syndrome-Presenting as Isolated Cochleovestibular Dysfunction.
Genes (Basel)
May 2024
Department of Head and Skin, Faculty of Medicine and Health Sciences, Ghent University Hospital, 9000 Ghent, Belgium.
CHARGE syndrome, characterized by a distinct set of clinical features, has been linked primarily to mutations in the gene. Initially defined by specific clinical criteria, including coloboma, heart defects, choanal atresia, delayed growth, and ear anomalies, CHARGE syndrome's diagnostic spectrum has broadened since the identification of . Variants in this gene exhibit considerable phenotypic variability, leading to the adoption of the term " disorder" to encompass a wider range of associated symptoms.
View Article and Find Full Text PDFHypopituitarism with secondary adrenocortical insufficiency and arginine vasopressin deficiency due to hypophysitis after COVID-19 vaccination: a case report.
BMC Endocr Disord
May 2024
Department of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakaecho, Itabashi-Ku, Tokyo, 173-0015, Japan.
Article Synopsis
- - A case study describes an 83-year-old woman who developed hypopituitarism and hormone deficiencies after receiving her fourth COVID-19 vaccine dose, showing rare side effects associated with vaccination.
- - She was admitted to the emergency department with difficulty moving and low consciousness, leading to findings of swelling in the brain and abnormally low cortisol levels, indicating adrenal insufficiency and other hormonal imbalances.
- - Treatment with medications like prednisolone and levothyroxine improved her condition, but her case highlights a unique instance of severe hormonal disruption linked to a COVID-19 vaccine.
The modern management of uterine fibroids-related abnormal uterine bleeding.
Fertil Steril
July 2024
Département de Gynécologie, Obstétrique et Médecine de la Reproduction, Faculté de Santé, Faculté de Médicine Paris Centre, Centre Hospitalier Universitaire (CHU), Université Paris-Cité, Paris, France.
Article Synopsis
- * Treatment options include medical therapies (like pain relievers and hormonal treatments) and surgical procedures (ranging from myomectomy to hysterectomy), but few drugs are specifically approved for treating UFs themselves, instead mostly focusing on symptom relief.
- * Management of iron deficiency and anemia is crucial, especially for those experiencing heavy bleeding, and treatment choices should involve discussions between patients and healthcare providers about personal goals, including fertility and uterine preservation.
The influence of body composition on the response to dynamic stimulation of the endocrine pituitary-testis axis.
Int J Obes (Lond)
September 2024
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Article Synopsis
- The study explores how body composition, particularly body mass index (BMI), affects the pituitary-testis axis in men, which is important for understanding testosterone levels.
- Findings show that higher BMI is linked to lower basal levels of luteinizing hormone (LH) and testosterone, indicating potential hormonal dysfunction in men with obesity.
- However, responses to dynamic hormone stimulation tests were less affected by BMI, suggesting that while basal hormone levels are significantly impacted by obesity, the body's ability to produce hormones in response to stimulation remains relatively stable.
Novel insights into minipuberty and GnRH: Implications on neurodevelopment, cognition, and COVID-19 therapeutics.
J Neuroendocrinol
October 2024
Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR_S1172, Lille, France.
Article Synopsis
- - The first 1000 days of life are crucial for brain and overall development, with a phenomenon called minipuberty influencing the hypothalamic-pituitary-gonadal (HPG) axis and reproductive health in humans and other mammals.
- - Recent studies suggest that minipuberty affects not only reproductive functions but also cognitive and sensory maturation, with specific roles of nitric oxide (NO) being identified in this process; cognitive deficits in conditions like Down syndrome may stem from a decline in GnRH production linked to minipuberty.
- - The impact of COVID-19 on GnRH production raises concerns about possible long-term effects on neurodevelopment, as GnRH neurons may be vulnerable to SARS-CoV-2, leading
High Population Frequency of p.Q106R in Malta: An Evaluation of Fertility and Hormone Profiles in Heterozygotes.
J Endocr Soc
January 2024
Department of Applied Biomedical Science, Faculty of Health Sciences, University of Malta, Msida, MSD 2080, Malta.
Article Synopsis
- The p.Q106R variant of the gonadotropin-releasing hormone receptor is linked to idiopathic hypogonadotropic hypogonadism (IHH) and was found at a significantly higher frequency in Maltese newborns compared to the global average.
- A study analyzed hormone levels and fertility data from 739 men and 239 women and identified 43 heterozygotes for the p.Q106R variant.
- The findings indicate that p.Q106R heterozygotes do not show abnormal hormone levels or fertility issues, suggesting that additional genetic factors may contribute to IHH in these individuals, and highlighting the variant’s likely founder status in Malta.
A novel mutation in gene in an Indian case with Gordon Holmes syndrome.
BMJ Case Rep
November 2023
Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.
Article Synopsis
- * Gordon Holmes syndrome, first described in 1908, is characterized by ataxia combined with hypogonadism and is linked to mutations in genes responsible for the ubiquitin-proteasome system.
- * The case report focuses on a 30-year-old male who exhibits symptoms like progressive ataxia, hypogonadotropic hypogonadism, cataracts, and brain abnormalities, ultimately revealing a mutation that confirms the diagnosis of Gordon Holmes syndrome.
Case Report: Multiple prolactinomas in a young man with Kallmann syndrome and familial hypocalciuric hypercalcemia.
Front Endocrinol (Lausanne)
November 2023
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Article Synopsis
A case of delayed postoperative bleeding after excision of endometrial polyp using resectoscope in an infertile woman with von Willebrand disease:a case report and literature review.
Fukushima J Med Sci
November 2023
Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine.
Article Synopsis
- Von Willebrand disease (VWD) is a bleeding disorder linked to issues with the von Willebrand factor, which is important for blood clotting.
- A case study focused on a 39-year-old woman with type 2A VWD who experienced delayed bleeding after surgery for endometrial polyps.
- Despite short-term treatment with VWF concentrate before and after surgery to prevent bleeding, the patient faced rebleeding on postoperative day 6, highlighting the need for careful monitoring and potential extended treatment.
Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death.
EBioMedicine
October 2023
Univ. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S 1172, DistAlz, Lille, France. Electronic address:
Article Synopsis
- Recent research links loss of gonadotropin-releasing hormone (GnRH) to cognitive decline, suggesting a similar mechanism may underlie neurological symptoms in post-COVID patients.
- Investigations revealed persistent low testosterone levels in some men post-COVID could indicate hypothalamic impact, connecting hormonal changes to cognitive issues.
- Dysfunction of GnRH neurons and certain brain cells due to SARS-CoV-2 could lead to reproductive, metabolic, and mental health problems, potentially increasing risks for neurological disorders across all ages.
Gonadotropin-Releasing Hormone Agonist Therapy and Longitudinal Bone Mineral Density in Congenital Adrenal Hyperplasia.
J Clin Endocrinol Metab
January 2024
The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892-1932, USA.
Article Synopsis
- Children with congenital adrenal hyperplasia (CAH) are at risk for early puberty, and Gonadotropin-releasing hormone analog (GnRHa) is commonly used to manage this condition despite concerns about bone mineral density (BMD).
- A study was conducted with 61 patients with classic CAH, comparing BMD outcomes between those treated with GnRHa and those who were not, finding no significant differences in BMD at adult height.
- While GnRHa treatment did not negatively impact BMD, there was a noted overall decrease in BMD as patients aged, which may be linked to long-term glucocorticoid use, but the treatment positively influenced height outcomes.
Pulmonary benign metastasizing leiomyoma in patients aged 45 years and younger: clinical features and novelty in treatment.
BMC Pulm Med
May 2023
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, National Clinical Research Center for Obstetric & Gynecologic Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Shuai Fu Yuan, Dong Cheng District, Beijing, China.
Article Synopsis
- Pulmonary benign metastasizing leiomyoma (PBML) is the most common extrauterine spread of uterine leiomyoma and is believed to be hormone-dependent, with limited studies focusing on younger women with this condition.
- In a review of 65 cases of PBML in women aged 45 and younger, findings showed that the median age at diagnosis was 39, with most cases presenting as bilateral solid lesions and a significant portion being treated with anti-estrogen therapies.
- Patients who had curative surgery combined with anti-estrogen treatment experienced better outcomes, while some patients benefited from sirolimus, which succeeded in managing symptoms without affecting hormone levels.
Successful pregnancy and delivery after ovulation induction therapy in a woman with congenital hypogonadotropic hypogonadism: a case report.
BMC Pregnancy Childbirth
May 2023
Department of Human Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, China.
Article Synopsis
- Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder that causes delayed puberty and infertility due to a lack of gonadotropin-releasing hormone; treatment often involves hormone therapy, particularly gonadotropins in females.* -
- The article presents a case study of a 29-year-old woman diagnosed with CHH, who underwent multiple cycles of gonadotropin therapy and successfully became pregnant, eventually delivering healthy twin girls via cesarean section.* -
- The findings emphasize the importance of early diagnosis and effective hormone replacement therapy for improving fertility outcomes in females with CHH.*
GNRHR-related central hypogonadism with spontaneous recovery - case report.
Ital J Pediatr
November 2022
Department of Pediatric Endocrinology, Diabetes and Metabolism, University Medical Centre Ljubljana, University Children's Hospital, Ljubljana, Slovenia.
Article Synopsis
- Congenital hypogonadotropic hypogonadism (CHH) is a genetic condition that leads to incomplete puberty and infertility due to insufficient gonadotropin secretion, often linked to mutations in the GNRHR gene.
- A case study of a 19-year-old male showed that after treatment with testosterone, he experienced unexpected spontaneous puberty and improvements in hormone levels two years after stopping the treatment.
- Genetic testing is important to differentiate CHH from similar conditions, as patients can sometimes recover naturally without ongoing hormone therapy.
Adult height of children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
J Formos Med Assoc
February 2023
Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
Article Synopsis
Article Synopsis
- Acute intermittent porphyria (AIP) is a genetic disorder that affects heme production in the liver and can lead to severe abdominal pain attacks that are hard to manage for some patients.* -
- A 20-year-old woman with recurrent AIP attacks did not improve with standard treatments, but showed significant relief after receiving a year-long treatment with gonadotropin-releasing hormone analogues and estrogen.* -
- The treatment resulted in the woman not experiencing any acute attacks and achieving long-term remission, suggesting this combination could be effective for menstrual-related AIP cases.*
Adult Height of Patients with SHOX Haploinsufficiency with or without GH Therapy: A Real-World Single-Center Study.
Horm Res Paediatr
August 2022
Unidade de Endocrinologia Genetica, Laboratorio de Endocrinologia Celular e Molecular LIM/25, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
Introduction: Isolated SHOX haploinsufficiency is a common monogenic cause of short stature. Few studies compare untreated and rhGH-treated patients up to adult height (AH). Our study highlights a growth pattern from childhood to AH in patients with SHOX haploinsufficiency and analyzes the real-world effectiveness of rhGH alone or plus GnRH analog (GnRHa).
View Article and Find Full Text PDFTreatment of congenital adrenal hyperplasia and Klinefelter Syndrome with central precocious puberty: a case report.
Transl Pediatr
February 2022
Department of Endocrinology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Article Synopsis
- * The boy was found to have high levels of gonadotropins and androgens, and his KS diagnosis was confirmed through karyotype analysis, marking the 7th documented case of this dual condition.
- * The patient underwent hormone therapies (GnRHa and rhGH) aimed at enhancing his growth potential, as his predicted adult height improved significantly; however, the possibility of future hypogonadism due to KS remains a concern.
Biallelic PROKR2 variants and congenital hypogonadotropic hypogonadism: a case report and a literature review.
Endocr J
July 2022
Department of Pediatrics, Keio University School of Medicine, Tokyo 160-8582, Japan.
Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder that causes gonadotropin-releasing hormone (GnRH) deficiency and sexual immaturity. CHH may accompany an abnormal sense of smell (Kallmann syndrome, KS) or no such manifestation (normosmic-CHH). This unusual combination of manifestations is explained by the fact that GnRH neurons originate in the olfactory placode and migrate to the forebrain during embryogenesis.
View Article and Find Full Text PDFWhole-Exome Sequencing Identified a Novel Mutation in RNF216 in a Family with Gordon Holmes Syndrome.
J Mol Neurosci
April 2022
Department of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Article Synopsis
- * A new mutation in the RNF216 gene, specifically p.E650X, has been identified in a patient who exhibited symptoms like speech difficulties, balance issues, cognitive decline, and azoospermia at 28 years old.
- * The study enhances understanding of the genetic basis of GHS and broadens the knowledge of RNF216 mutations across different ethnic groups.