4 results match your criteria: "Golisano Children's Hospital and University of Rochester Medical Center[Affiliation]"
Sphingolipid classes and the interrelationship with pediatric asthma and asthma risk factors.
Allergy
February 2024
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Article Synopsis
- The study investigates the link between sphingolipid metabolism and childhood asthma, focusing on how different classes of sphingolipids interact with asthma risk factors.
- Researchers analyzed blood samples from nearly 1,000 children to explore associations between sphingolipids, asthma, and specific risk factors like genetic markers, vitamin D levels, and gut health.
- The findings indicate that while overall sphingolipid levels correlate with asthma, specific subclasses (like ceramides) have distinct roles, with some linked to increased asthma risk factors rather than the disease itself.
Elevated third trimester corticosteroid levels are associated with fewer offspring infections.
Sci Rep
June 2023
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA.
Respiratory infections are a leading cause of morbidity and mortality in early life, and recurrent infections increase the risk of developing chronic diseases. The maternal environment during pregnancy can impact offspring health, but the factors leading to increased infection proneness have not been well characterized during this period. Steroids have been implicated in respiratory health outcomes and may similarly influence infection susceptibility.
View Article and Find Full Text PDFReduced Steroid Metabolites Identify Infection-Prone Children in Two Independent Pre-Birth Cohorts.
Metabolites
November 2022
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Recurrent respiratory infections are a leading cause of morbidity and mortality in early life, but there is no broadly accepted means to identify infection-prone children during this highly vulnerable period. In this study, we investigated associations between steroid metabolites and incident respiratory infections in two pre-birth cohorts to identify novel metabolomic signatures of early infection proneness. Children from the Vitamin D Antenatal Asthma Reduction Trial and the Copenhagen Prospective Studies on Asthma in Childhood were included, and profiling was performed on plasma samples collected at ages 1 and 6 years.
View Article and Find Full Text PDFBeyond obesity: The complex relationship between early growth trajectories and later lung function.
J Allergy Clin Immunol
September 2021
Division of Pediatric Pulmonary Medicine, Department of Pediatrics, Golisano Children's Hospital and University of Rochester Medical Center, Rochester, NY. Electronic address: