1,122 results match your criteria: "Goiter Nontoxic"
Causal effects of thyroid volume change on thyroid disease: a Mendelian randomization study.
Gland Surg
November 2024
Department of Gastrointestinal Gland Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Background: Observational studies have suggested an association between thyroid volume changes and thyroid disease, but the causal relationship and direction of these effects remain unclear. This study employs a two-sample Mendelian randomization (MR) approach to assess the effect of thyroid volume on clinically common benign and malignant thyroid diseases.
Methods: Summary data from genome-wide association studies (GWAS) were utilized for secondary data analysis to investigate the link between thyroid volume and disease.
Total Thyroidectomy Versus Partial Thyroidectomy for Non-Toxic Multinodular Goiter: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Indian J Surg Oncol
December 2024
Otolaryngology-Head and Neck Surgery, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Ministry of the National Guard Health Affairs, Jeddah, Kingdom of Saudi Arabia.
Unlabelled: Thyroid follicular nodular disease (non-toxic multinodular goiter), the commonest thyroid disorder, can be managed with different surgical methods, including total thyroidectomy (TT), near-total thyroidectomy (NTT), subtotal thyroidectomy (STT), and Dunhill operation (DO). This systematic review and meta-analysis aimed to provide an update on the role of TT versus NTT, STT, or DO in MNG concerning goiter recurrence, thyroid cancer incidence, and reported complications. We conducted a systematic literature search in Medline, EMBASE, and CENTRAL.
View Article and Find Full Text PDFA Comprehensive Mendelian Randomization Study Investigating Multiple Exposures and Outcomes: Focusing on Nontoxic Goitre and Type 2 Diabetes Mellitus.
Clin Endocrinol (Oxf)
November 2024
School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China.
Article Synopsis
Nodule-specific NRF2-targeted upregulation in patients with KEAP1 mutations and familial nontoxic multinodular goiter.
J Clin Endocrinol Metab
October 2024
Center for Excellence in Thyroid Care, Kuma Hospital, Kobe, Japan.
Article Synopsis
- KEAP1 is a protein that usually promotes the degradation of NRF2, a factor that helps cells respond to oxidative stress, but mutations in KEAP1 can lead to diseases like familial multinodular goiter.
- This study analyzed 39 patients with this goiter, identifying five with specific KEAP1 mutations that did not correlate with any other mutations related to goiter.
- Results showed that these mutations led to increased activity of NRF2, causing thyroid hyperplasia and a protective response against oxidative stress, indicated by the upregulation of antioxidant and detoxification genes.
Analyzing Comorbidity Patterns in Patients With Thyroid Disease Using Large-Scale Electronic Medical Records: Network-Based Retrospective Observational Study.
Interact J Med Res
October 2024
Department of Nuclear Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Article Synopsis
- Thyroid disease (TD) is a significant global health issue, but the patterns of comorbidities associated with it are not well understood.
- * This study used real-world health data to analyze the comorbidity patterns in adult patients with TD, focusing on various subgroups by sex, age, and type of disease.
- * Findings showed that comorbidities are prevalent and complex in TD patients, with factors like age and disease type influencing the number and type of comorbid conditions.
Uncovering a Causal Connection between Gut Microbiota and Six Thyroid Diseases: A Two-Sample Mendelian Randomization Study.
Biology (Basel)
September 2024
School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Article Synopsis
- Recent research links gut microbiota (GM) to thyroid diseases (TDs), but the causal relationships are not fully understood.
- A two-sample Mendelian randomization analysis using genome-wide association study data identified 32 microbial taxa associated with six different TDs, with some providing protective effects and others raising risks.
- The study concludes that specific gut microbiota are causally related to thyroid diseases, paving the way for future investigations and potential new treatments.
Incidental Thyroid Malignancy in Surgical Patients With Benign Thyroid Disease.
J Surg Res
October 2024
Division of Endocrine Surgery, DeWitt Daughtry Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida.
Article Synopsis
- The study investigates the rising rate of incidental thyroid malignancy (ITM) found in patients undergoing surgery for benign thyroid disease (BTD) without preoperative concerns about cancer.
- An analysis of 2,528 patients revealed that 22.9% had ITM, with the majority being women and having a mean BMI of 29.6.
- The findings suggest a significant association between higher BMI and the occurrence of ITM, indicating that patients with higher BMI and BTD may need closer monitoring.
The Coexistence of Occult (Latent) Thyroid Cancer and Multinodular Goiter After Total Thyroidectomy: A Retrospective Study.
Cureus
June 2024
Second Surgical Department, 424 General Military Hospital, Thessaloniki, GRC.
Article Synopsis
- Multinodular goiter (MNG) is a common thyroid condition with multiple nodules, often benign but sometimes harboring latent cancer, necessitating thorough investigation and management.* -
- A study of 412 patients who underwent total thyroidectomy revealed that 14.02% had concealed thyroid carcinoma within MNG, predominantly of the papillary type.* -
- The findings highlight the need for careful evaluation of patients with MNG due to the potential for malignancy, particularly in cases that may also involve other thyroid disorders like Hashimoto's thyroiditis.*
Establishing and Monitoring an Effective Management of Benign Nontoxic Multinodular Goitre in Kuwait "Utilizing Two Different Dose Levels of Recombinant Human TSH in Combination with Radioactive Iodine".
Gulf J Oncolog
May 2024
Department of Endocrinology, Adan Hospital, Ministry of Health, Kuwait.
Introduction: rhTSH-assisted radioiodine therapy of multinodular goiter is not fully known and only a few studies, with a limited number of patients have evaluated the effect of rhTSH assisted radioiodine therapy beyond 1 year. Though there is an effective and safe management of benign non-toxic MNG available, it is not applicable to all patient categories in Kuwait covering the impact of the past environmental events (Gulf War) and the genetic relation. The proposed project aims to address those points raised, that is exclusive to the Kuwait population.
View Article and Find Full Text PDF[Topical Use of Cannabis in Inflammatory Diseases in patients of the IPS Salud Social in Barranquilla, Colombia].
Rev Alerg Mex
February 2024
Centro de Investigación e Innovación en Salud, Previsalud, Salud Social IPS, Barranquilla, Colombia.
Article Synopsis
- The study aimed to explore the use of topical cannabis as a pain relief method for patients with various inflammatory diseases at Salud Social I.P.S from May to July 2023.
- A total of 23 patients with conditions like arthritis, goiter, and carpal tunnel syndrome were analyzed, and results showed that most experienced pain relief after two months.
- While the study supports the analgesic properties of cannabis, it emphasizes the need for more research to thoroughly understand its effects and benefits in treating inflammatory diseases.
Effect of thyroid hormone replacement therapy on mortality rate in patients undergoing total or hemithyroidectomy for benign multinodular goitre.
BJS Open
January 2024
Department of Clinical Sciences-Lund, Lund University, Sweden.
Background: Thyroid surgery for benign non-toxic nodular goitre is a common endocrine surgical procedure. It is not known whether thyroid hormone replacement therapy following surgery for benign thyroid disease influences mortality or morbidity rates.
Methods: A retrospective observational study was conducted using national registries in Sweden.
Tracheomalacia following a total thyroidectomy in a patient with a large non-toxic goiter: A case report.
Int J Surg Case Rep
March 2024
Surgery Department, Medical Faculty of Universitas Sebelas Maret, Dr. Moewardi Hospital, Surakarta, Indonesia.
Introduction: Nontoxic nodular goiter is one of the most prevalent thyroid conditions worldwide. Thyroidectomy for large goiters has a relatively high risk of postoperative airway obstruction, with tracheomalacia being one of the potential complications.
Case Report: A 61-year-old woman complained of a lump in her neck for 45 years.
Retrospective Diagnosis of Ca Thyroid on Thyroid Pertechnetate Scan -A part of Routine Post Thyroidectomy Work up For Nontoxic Multi Nodular Goiter.
J Pak Med Assoc
January 2024
Department of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore.
Article Synopsis
- Unsuspected thyroid cancer can be found in multinodular goiter (MNG) with a malignancy risk of 7-9%.
- Fine needle aspiration (FNAc) is used if there are suspicious ultrasound findings, and benign results usually don't require surgery unless there are pressure symptoms or cosmetic issues.
- The case presented involves a patient who unexpectedly had papillary thyroid cancer detected during a thyroid scan.
Predictive factors for the outcome of radioiodine therapy in patients with benign thyroid diseases.
Nuklearmedizin
April 2024
Department of Nuclear Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany.
Article Synopsis
Phospholipase C-γ as a Potential Therapeutic Target for Graves' Orbitopathy.
Endocrinol Metab (Seoul)
December 2023
Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.
Article Synopsis
- Phospholipase C-γ (PLC-γ) is important for immune responses and is linked to inflammatory disorders; this study focused on its role in Graves' orbitopathy (GO) and tested a specific inhibitor, U73122.
- The researchers found that PLCG1 and PLCG2 were expressed more in GO tissues compared to normal ones, and that U73122 effectively reduced inflammation markers in GO fibroblasts and normal fibroblasts.
- The study concludes that inhibiting PLC-γ with U73122 may lower inflammatory responses and suggests PLC-γ as a potential therapeutic target for treating Graves' orbitopathy.
Borderline personality disorder and thyroid diseases: a Mendelian randomization study.
Front Endocrinol (Lausanne)
October 2023
Department of Thyropathy, Sunsimiao Hospital, Beijing University of Chinese Medicine, Tongchuan, Shanxi, China.
Article Synopsis
- - The study investigated the potential causal relationship between borderline personality disorder (BPD) and four thyroid diseases using a method called Mendelian randomization analysis.
- - Results indicated that individuals with BPD are 1.13 times more likely to develop non-toxic single thyroid nodules, but no significant link was found between BPD and other thyroid conditions like hyperthyroidism or hypothyroidism.
- - The findings suggest that monitoring thyroid health is important for patients with BPD, but more research is needed to explore connections between other mental illnesses and thyroid diseases.
Management of a Long-Standing Huge Goiter During a Humanitarian Mission: A Case Report.
Cureus
May 2023
Plastic Surgery Department, University of Pittsburgh School of Medicine, Los Angeles, USA.
Article Synopsis
- * A case report details a 50-year-old woman with a giant goiter that developed over 30 years, treated during a humanitarian mission with a total thyroidectomy.
- * The successful surgery demonstrates that effective management of giant goiters is possible even in areas with limited medical resources.
Novel pathogenic variant of in an adolescent with multinodular goiter, ovarian Sertoli-Leydig cell tumor and pineal parenchymal tumor of intermediate differentiation.
J Pediatr Endocrinol Metab
August 2023
Master of Science, Endocrinology Department, Hospital de Especialidades, UMAE CMN Siglo XXI, IMSS, Avenida Cuauhtémoc N. 330 Colonia Doctores. C.P. 06720, Mexico City, Mexico.
Article Synopsis
- A 13-year-old girl exhibited symptoms of a non-toxic multinodular goiter and developed an ovarian Sertoli-Leydig cell tumor, alongside a pineal parenchymal tumor.
- Next-generation sequencing identified a new pathogenic variant in the DICER1 gene, specifically a germline mutation (exon 16, c2488del [pGlu830Serfs*2]).
- This case highlights that mutations in the DICER1 gene can lead to a genetic predisposition for various types of tumors, ranging from benign to malignant, throughout a person's life.
Total vs less than total thyroidectomy for benign multinodular non-toxic goiter: an updated systematic review and meta-analysis.
Langenbecks Arch Surg
May 2023
Department of PSM and Biostatistics, Rama Medical College, Kanpur, India.
Article Synopsis
- - A recent meta-analysis examined the outcomes of total thyroidectomy (TT) versus less than total thyroidectomy (LTT) in treating benign multinodular non-toxic goiter, utilizing data from five randomized controlled trials (RCTs).
- - TT showed a lower recurrence rate for goiter compared to LTT, but adverse events like nerve damage and permanent parathyroid issues were similar in both groups, except for temporary hypoparathyroidism being more common with TT.
- - The analysis highlighted concerns about bias in the studies reviewed and concluded there was no definitive advantage or disadvantage of TT over LTT concerning recurrence and re-operation rates, with overall evidence quality rated as low to moderate.
Background: There has recently been an increase in the incidental histological diagnosis of papillary thyroid microcarcinoma (I-PTMC), that varies from 3.5% in autopsies studies, to 5.2% in thyroid specimens from thyroid surgery, up to 9.
View Article and Find Full Text PDFComparison of surgical completeness in patients operated on conventional open total thyroidectomy (OT) or trans-axillary robot-assisted total thyroidectomy (RATT) by a single axillary approach.
Updates Surg
August 2023
Department of Surgical, Medical, Molecular Pathology and Critical Area, Endocrine Surgery Unit, Pisa University Hospital, Via Paradisa 2, Edificio 30 E, 56100, Pisa, Italy.
Article Synopsis
- Trans-axillary robot-assisted total thyroidectomy (RATT) is gaining worldwide acceptance, but its effectiveness compared to traditional open thyroidectomy (OT) is still under review.
- A study involving 100 patients with various thyroid conditions revealed no significant differences in surgical completeness or post-operative thyroid remnants between RATT and OT methods.
- Both procedures showed equal effectiveness in achieving surgical completeness, indicating that RATT is a viable alternative to OT without increasing complication rates.
Simple nontoxic goiter in the portrayal of Saints: a magnificent representation in one piece of art.
J Endocrinol Invest
December 2023
Department of Endocrinology and Internal Medicine, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.
Article Synopsis
- Warthin-like papillary thyroid carcinoma is a rare type of thyroid cancer that has a very positive prognosis and is often found alongside lymphocytic thyroiditis.
- Its diagnosis is usually straightforward due to its distinct histological characteristics, which do not typically require additional chemical tests.
- A case study presented involves a 56-year-old woman with a non-toxic multinodular goiter, where histological examination revealed the presence of this uncommon cancer variant.
[Evaluation of the nanosize and stability of aqueous dispersions of iodinecontaining conjugates based on carriers of plant origin, promising for iodine enrichment of foods].
Vopr Pitan
January 2023
K.G. Razumovsky Moscow State University of Technologies and Management (FCU), Research Center "Food Technologies", 453850, Meleuz, Meleuzovsky district, Russian Federation.
Article Synopsis
- * Recent advancements include creating these compounds using natural polymers like pectin, casein, and inulin, along with potential new sources such as Stevia rebaudiana glycosides.
- * The research aims to validate the formation of an iodine-glycoside conjugate and evaluate its stability in aqueous dispersions compared to iodine compounds with natural polymer carriers using spectroscopy and nanostructural analysis.