It's noisy out there! A review of denoising techniques in cryo-electron tomography.

Cryo-electron tomography is the only technique that can provide sub-nanometer resolved images of cell regions or even whole cells, without the need of labeling or staining methods. Technological advances over the past decade in electron microscope stability, cameras, stage precision and software have resulted in faster acquisition speeds and considerably improved resolution. In pursuit of even better image resolution, researchers seek to reduce noise - a crucial factor affecting the reliability of the tomogram interpretation and ultimately limiting the achieved resolution.