Bayesian Borrowing With Multiple Heterogeneous Historical Studies Using Order Restricted Normalized Power Prior.

The recent U.S. Food and Drug Administration guidance on complex innovative trial designs acknowledges the use of Bayesian strategies to incorporate historical information based on clinical expertise and data similarity.

The Presence of Two Distinct Lineages of the Foot-And-Mouth Disease Virus Type A in Russia in 2013-2014 Has Significant Implications for the Epidemiology of the Virus in the Region.

Molecular surveillance of FMD epidemiology is a fundamental tool for advancing our understanding of virus biology, monitoring virus evolution, and guiding vaccine design. The accessibility of genetic data will facilitate a more comprehensive delineation of FMDV phylogeny on a global scale. In this study, we investigated the FMDV strains circulating in Russia during the 2013-2014 period in geographically distant regions utilizing whole genome sequencing followed by maximum-likelihood phylogenetic reconstruction of whole genome and VP1 gene sequences.

Peptides as Versatile Regulators in Cancer Immunotherapy: Recent Advances, Challenges, and Future Prospects.

The emergence of effective immunotherapies has revolutionized therapies for many types of cancer. However, current immunotherapy has limited efficacy in certain patient populations and displays therapeutic resistance after a period of treatment. To address these challenges, a growing number of immunotherapy drugs have been investigated in clinical and preclinical applications.

Global Transcriptomic Analysis of Inbred Lines Reveal Candidate Genes for Response to Maize Lethal Necrosis.

Maize lethal necrosis (MLN) is a significant threat to food security in Sub-Saharan Africa (SSA), with limited commercial inbred lines displaying tolerance. This study analyzed the transcriptomes of four commercially used maize inbred lines and a non-adapted inbred line, all with varying response levels to MLN. RNA-Seq revealed differentially expressed genes in response to infection by maize chlorotic mottle virus (MCMV) and sugarcane mosaic virus (SCMV), the causative agents of MLN.

Cellulose-Based Aerogels for Environmentally Sustainable Applications: A Review of the Production, Modification, and Sorption of Environmental Contaminants.

Environmental pollution, stemming from the disposal of contaminants, poses severe threats to ecosystems and human health. The emergence of a new class of pollutants, termed emerging contaminants (ECs), in soil, water, and air has raised global concerns, aligning with the UN 2030 Agenda's Sustainable Development Goals. Aerogels, three-dimensional structures with high porosity and low density, offer promise in addressing this issue.

HIV Drug Resistance Profile in Clients Experiencing Treatment Failure After the Transition to a Dolutegravir-Based First-Line Antiretroviral Treatment Regimen in Mozambique.

Real-world data on HIV drug resistance (HIVDR) after transitioning to tenofovir disoproxil fumarate/lamivudine/dolutegravir (TLD) are limited. We assessed HIVDR rates and patterns in clients with virological failure (VF) after switching from an NNRTI-based regimen to TLD. A cross-sectional study was conducted in Gaza, Mozambique (August 2021-February 2022), including adults on first-line ART for ≥12 months who transitioned to TLD and had unsuppressed viral load (VL) ≥ 1000 copies/mL six months post-transition.

Spatial Characterization of Woody Species Diversity in Tropical Savannas Using GEDI and Optical Data.

Developing the capacity to monitor species diversity worldwide is of great importance in halting biodiversity loss. To this end, remote sensing plays a unique role. In this study, we evaluate the potential of Global Ecosystem Dynamics Investigation (GEDI) data, combined with conventional satellite optical imagery and climate reanalysis data, to predict in situ alpha diversity (Species richness, Simpson index, and Shannon index) among tree species.

Seed Protein Content Estimation with Bench-Top Hyperspectral Imaging and Attentive Convolutional Neural Network Models.

Wheat is a globally cultivated cereal crop with substantial protein content present in its seeds. This research aimed to develop robust methods for predicting seed protein concentration in wheat seeds using bench-top hyperspectral imaging in the visible, near-infrared (VNIR), and shortwave infrared (SWIR) regions. To fully utilize the spectral and texture features of the full VNIR and SWIR spectral domains, a computer-vision-aided image co-registration methodology was implemented to seamlessly align the VNIR and SWIR bands.

Non-Intrusive Monitoring of Vital Signs in the Lower Limbs Using Optical Sensors.

Invisible health monitoring is currently a topic of global interest within the scientific community. Sensorization of everyday objects can provide valuable health information without requiring any changes in people's routines. In this work, a feasibility study of photoplethysmography (PPG) acquisition in the lower limbs for continuous and real-time monitoring of the vital signs, including heart rate (HR) and respiratory rate (RR), is presented.

Plasma Endothelin-1 Levels: Non-Predictors of Alzheimer's Disease Reveal Age Correlation in African American Women.

Alzheimer's disease (AD) and related dementias (ADRD) disproportionately impact racial and ethnic minorities. Contributing biological factors that explain this disparity have been elusive. Moreover, non-invasive biomarkers for early detection of AD are needed.

Dysmenorrhea Among Women Living in Saudi Arabia: Prevalence, Determinants, and Impact.

Dysmenorrhea, or painful menstruation, is one of the most prevalent conditions among adolescents and young females globally, significantly affecting academic performance, quality of life, and social interactions. Despite its high prevalence, dysmenorrhea has been rarely investigated in Saudi Arabia, resulting in a scarcity of national data. This study aimed to evaluate the prevalence, severity, and determinants of dysmenorrhea among females in Saudi Arabia.

Developmental Proteomics Reveals the Dynamic Expression Profile of Global Proteins of (Parthenogenesis).

is used as an experimental animal model for the study of three-host ticks due to its special life cycle and easy maintenance in the laboratory and in its reproduction. The life cycle of goes through a tightly regulated life cycle to adapt to the changing host and environment, and these stages of transition are also accompanied by proteome changes in the body. Here, we used the isobaric tags for a relative and absolute quantification (iTRAQ) technique to systematically describe and analyze the dynamic expression of the protein and the molecular basis of the proteome of in seven differential developmental stages (eggs, unfed larvae, engorged larvae, unfed nymphs, engorged nymphs unfed adults, and engorged adults).

Evaluating the Impact of Climate Change on the Asia Habitat Suitability of Using the MaxEnt Model.

Butterflies are highly sensitive to climate change, and , as an endangered butterfly species, is also affected by these changes. To enhance the conservation of and effectively plan its protected areas, it is crucial to understand the potential impacts of climate change on its distribution. This study utilized a MaxEnt model in combination with ArcGIS technology to predict the global potential suitable habitats of under current and future climate conditions, using the species' distribution data and relevant environmental variables.

Acute Severe Hypoxia Decreases Mitochondrial Chain Complex II Respiration in Human Peripheral Blood Mononuclear Cells.

Peripheral blood mononuclear cells' (PBMCs) mitochondrial respiration is impaired and likely involved in myocardial injury and heart failure pathophysiology, but its response to acute and severe hypoxia, often associated with such diseases, is largely unknown in humans. We therefore determined the effects of acute hypoxia on PBMC mitochondrial respiration and ROS production in healthy volunteers exposed to controlled oxygen reduction, achieving an inspired oxygen fraction of 10.5%.

In-Situ Investigation of Copepod Predators of Theronts from Fish-Farming Pond.

, a parasitic ciliate, causes "white spot disease" in freshwater fish and poses a significant threat to global freshwater aquaculture. Eliminating the free-swimming theront stage from the aquaculture environment is a critical measure for controlling infections. The natural predator of theronts in fish-farming ponds were identified using fluorescent dye-labelled live theronts and quantitative PCR; meanwhile, the zooplankton community composition in the positive ponds of detected by quantitative PCR were analyzed by eDNA metabarcoding assay.

Short-Circuit Performance Analysis of Commercial 1.7 kV SiC MOSFETs Under Varying Electrical Stress.

The short-circuit (SC) robustness of SiC MOSFETs is critical for high-power applications, yet 1.2 kV devices often struggle to meet the industry-standard SC withstand time (SCWT) under practical operating conditions. Despite growing interest in higher voltage classes, no prior study has systematically evaluated the SC performance of 1.

Modeling and Characterization of Multilayer Piezoelectric Stacks via Dynamic Stiffness Method.

Multilayer piezoelectric stacks, which are multiple layers of piezoelectric materials placed on top of each other, are widely used to achieve precise linear movement and high-force generation. In this paper, a dynamic stiffness (DS) method for the dynamic vibration analysis of multilayer piezoelectric stacks is presented. First, the general solutions for all physical quantities of the three vibration contributions (i.

A New Antibody-Cytokine Construct Targeting Natural Killer Cells: An Immunotherapeutic Approach to Chronic Lymphocytic Leukemia.

In chronic lymphocytic leukemia (CLL), natural killer (NK) cells show a dysfunctional phenotype that correlates with disease progression. Our aim was to restore NK cell functionality in CLL through a specifically targeted IL15-stimulating activity; IL15 targeting could, in fact, potentiate the activity of NK cells and reduce off-target effects. We designed and developed a cis-acting immunocytokine composed of an anti-CD56 single-chain Fragment variable (scFv) and IL15, labeled scFvB1IL15.

Varroa Volatiles Offer Chemical Cues to Honey Bees for Initial Parasitic Recognition.

Olfaction mediated by the antennae is a vital sensory modality for arthropods and could be applied as a tool in pest control. The ectoparasitic mite poses a significant threat to the health of the honey bee worldwide and has garnered global attention. To better understand the chemical ecology of this host-parasite relationship, we collected and characterized the volatile organic compounds (VOCs) from and used electroantennography (EAG) to record the responses of honey bee ( and ) antennae to the different VOCs.

Effectiveness of a Novel Liposomal Methylglyoxal-Tobramycin Formulation in Reducing Biofilm Formation and Bacterial Adhesion.

The emergence of multidrug-resistant bacteria presents a significant global health threat. Liposomal antibiotics have shown a potential to improve antibiotic delivery and efficacy. This study aimed to develop liposomes encapsulating tobramycin (TOB) and methylglyoxal (MGO) to enhance TOB activity while reducing bacterial adhesion and biofilm formation.

MDA-DETR: Enhancing Offending Animal Detection with Multi-Channel Attention and Multi-Scale Feature Aggregation.

Conflicts between humans and animals in agricultural and settlement areas have recently increased, resulting in significant resource loss and risks to human and animal lives. This growing issue presents a global challenge. This paper addresses the detection and identification of offending animals, particularly in obscured or blurry nighttime images.

Assessing Heat Resistance and Selecting Heat-Resistant Individuals of Largemouth Bass () with Tiered Thermal Exposure.

Largemouth bass (LMB, ), a commercially important farmed fish, is vulnerable to heat stress. Breeding heat-resistant LMB is highly desirable in the face of global warming. However, we still lack an efficient method to assess the heat resistance of LMB.

Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease.

The global incidence and mortality rates of alcohol-related liver disease are on the rise, reflecting a growing health concern worldwide. Alcohol-related liver disease develops due to a complex interplay of multiple reasons, including oxidative stress generated during the metabolism of ethanol, immune response activated by immunogenic substances, and subsequent inflammatory processes. Recent research highlights the gut microbiota's significant role in the progression of alcohol-related liver disease.

Explaining the Correlates of the Multi-Theory Model (MTM) of Health Behavior Change in Visual (Structural) Colorectal Cancer Screening Examinations.

Colorectal cancer (CRC) ranks third in terms of global cancer prevalence and is the second most common cause of cancer-related mortality. Although CRC rates are decreasing in the United States, inequalities still exist despite the effectiveness of invasive screening methods, such as colonoscopy, flexible sigmoidoscopy, and computed tomography (CT) colonography in detecting colorectal cancer. Many current interventions promoting CRC screening do not utilize a modern theory-based approach, which has led to the low utilization of these screening methods.

Strategic Responses to Employee Well-Being Issues in VUCA (Volatile, Uncertain, Complex, and Ambiguous) Conditions: Expanding the JD-R (Job Demands-Resources) Model with Job Crafting.

Current work environments, driven by globalization, demographic changes, and digitalization, demand substantial adaptation, which leads to decreased employee well-being. While occupational psychology research has identified supportive mechanisms, it often lacks a deepened understanding of how interventions function. This study aims to analyze the impacts of VUCA contexts and leadership behavior on job crafting, focusing on white-collar workers.