66 results match your criteria: "Global Center for Evidence Synthesis[Affiliation]"

Mystery flu-like outbreak raises another alarm in Congo: The next disease X?

New Microbes New Infect

February 2025

Department of Paediatrics, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, 411018, Maharashtra, India.

View Article and Find Full Text PDF

Background: Diabetes mellitus presents significant public health challenges worldwide. While its prevalence and management in the general population have been extensively studied, comprehensive research on diabetes among incarcerated individuals is lacking. This study aims to conduct a systematic review and -analysis to determine the prevalence of diabetes within the prison population.

View Article and Find Full Text PDF

Background: Cardiovascular diseases (CVD) are leading contributors to global morbidity and mortality, significantly influenced by non-optimal temperatures. This study projects the impact of temperature fluctuations on CVD through 2050, considering environmental and climate changes.

Methods: Using Global Burden of Disease (GBD) study data, we analysed age-standardized death rates (ASDR) and disability-adjusted life years (ASR DALYs) related to non-optimal temperatures.

View Article and Find Full Text PDF

Background: The rapid rise of non-communicable diseases, particularly type 2 diabetes mellitus (T2DM), poses a significant global public health challenge, with South Asia experiencing an increasingly severe burden. This study aimed to analyse historical trends of T2DM across South Asia from 1990 to 2021 and forecast incidence through 2031.

Research Design And Methods: We carried out analysis based on the data from the 2021 Global burden of disease study.

View Article and Find Full Text PDF

Background: Neurological disorders are a major global health concern, especially in BRICS nations (Brazil, Russia, India, China, South Africa), where demographic and socio-economic changes have amplified their impact. This study evaluates trends in incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALYs) associated with neurological diseases in these countries from 1990 to 2021, focusing on sex disparities and key risk factors.

Methods: Data were obtained from the Global Burden of Disease (GBD) 2021 database.

View Article and Find Full Text PDF

Objectives: The objectives of this study were to analyze trends in prostate cancer incidence, incidence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021 via data from the Global Burden of Disease (GBD) study in South Asia. Additionally, the study projects future prostate cancer incidence rates up to 2031 to inform public health interventions in South Asia.

Methods: Data covering South Asian countries such as Bangladesh, Bhutan, India, Nepal, and Pakistan were obtained from the GBD 2021 portal.

View Article and Find Full Text PDF

Understanding current trends and incidence projections of prostate cancer in India: A comprehensive analysis of national and regional data from the global burden of disease study (1990 -2021).

Cancer Epidemiol

February 2025

University Center for Research and Development, Chandigarh University, Mohali, Punjab 140413, India; Medical Laboratories Techniques Department, AL-Mustaqbal University, Hillah, Babil 51001, Iraq. Electronic address:

Background: The study aims to explore the burden and trends of prostate cancer (PC) in India at the state level from 1990 to 2021, using data from the Global Burden of Disease (GBD) 2021 study.

Methods: The health metrics including age-standardised incidence rates (ASIR), prevalence rates (ASPR), disability-adjusted life years (ASDR), and mortality rates (ASMR) per 100,000 for PC were analysed across Indian states and union territories. Join point regression analysis was employed to identify significant changes in these metrics over time.

View Article and Find Full Text PDF
Article Synopsis
  • The outbreak of Monkeypox (Mpox), especially the clade 1b variant, has become a significant global health issue, particularly in Africa, which is experiencing ongoing epidemics that require urgent attention and study.
  • This research analyzes data from the most affected African countries, using time series techniques to predict Mpox trends and assess the growth in new cases from August 2023 to August 2024.
  • Results indicate a worrying upward trend in Mpox cases, with projections suggesting nearly 6,923 cumulative cases in about 65 weeks, highlighting the need for ongoing monitoring and tailored public health responses to manage the outbreak effectively.
View Article and Find Full Text PDF
Article Synopsis
  • West Nile Virus (WNV) poses a significant global health risk, expanding into new regions due to climate change enhancing mosquito activity, leading to year-round virus transmission.
  • Recent advancements in genomic technologies have improved understanding of WNV's behavior and potential treatment options, yet the lack of an approved vaccine means management relies heavily on supportive care for severe cases.
  • There is a pressing need for innovative vector control methods and adaptive public health strategies that integrate research, policy, and community efforts to effectively combat WNV's evolving challenges.
View Article and Find Full Text PDF

Reversible cerebral vasoconstriction syndrome (RCVS) is a rare neurological disorder characterized by transient constriction and dilation of cerebral arteries, leading to severe headaches and neurological deficits. This case report describes a 41-year-old woman with chronic anemia, acute chronic kidney disease, type 2 diabetes mellitus, and rheumatoid arthritis who developed RCVS following transfusion of packed red blood cells (PRBCs). She experienced sudden-onset seizures and a thunderclap headache 5 days post-transfusion.

View Article and Find Full Text PDF

Association of celiac disease and myocardial infarction: a systematic review and meta-analysis.

BMC Cardiovasc Disord

November 2024

Global Health and Infectious Diseases Control Institute, Nasarawa State University, Keffi, Nigeria.

Article Synopsis
  • Celiac disease (CD) is an autoimmune disorder linked to gluten intolerance that may affect cardiovascular health, with some studies suggesting a connection to myocardial infarction (MI), although results have been inconsistent.* -
  • A systematic review and meta-analysis of 8 studies were conducted to evaluate the risk of MI in adults with CD, using data from databases like PubMed and Web of Science, analyzed with R software.* -
  • The analysis found no significant association between CD and MI, but indicated high variability in study results, suggesting a need for more research on larger, more uniform samples to clarify potential cardiovascular risks for CD patients.*
View Article and Find Full Text PDF

Tuberculosis in South Asia: A regional analysis of burden, progress, and future projections using the global burden of disease (1990-2021).

J Clin Tuberc Other Mycobact Dis

December 2024

Unit of Immunology and Chronic Disease, Institute of Environmental Medicine, Karolinska Institutet, 17177 Stockholm, Sweden.

Article Synopsis
  • Tuberculosis (TB) remains a significant public health crisis in South Asia, with varied progress among countries in reducing incidence and mortality rates from 1990 to 2021.
  • The study used data from the Global Burden of Disease (GBD) and identified notable declines in TB indicators, particularly in Bangladesh and Bhutan, while India, Pakistan, and Nepal still face high burdens.
  • Future projections suggest continued decline in TB rates, but targeted interventions are essential, especially in nations with inadequate progress, to meet WHO goals by 2035.
View Article and Find Full Text PDF

Chandipura virus: A looming threat to children in India.

New Microbes New Infect

December 2024

Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

View Article and Find Full Text PDF

Murine typhus: an underappreciated influence on human disease transmission dynamics.

Infect Dis (Lond)

January 2025

Department of Paediatrics, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.

Murine typhus, a vector-borne illness transmitted by fleas and caused by , presents significant public health challenges globally. Despite its impact, it often remains underrecognized in health systems. This disease is characterized by non-specific symptoms such as fever, rash, and severe complications in cases involving neurological or multi-organ involvement.

View Article and Find Full Text PDF

The silent spread: why we need increased awareness of Crimean-Congo haemorrhagic fever.

Infect Dis (Lond)

January 2025

Department of Paediatrics, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.

Crimean-Congo Hemorrhagic Fever (CCHF) presents significant global health challenges, highlighted by its sporadic nature and high fatality rates. The manuscript emphasizes the disease's tendency to be under-recognized and the diagnostic challenges it poses, often mimicking other illnesses and leading to frequent misdiagnosis. There is a noted absence of robust diagnostic tools, specific treatments, or vaccines, leaving only supportive care generally available.

View Article and Find Full Text PDF