3 results match your criteria: "Global Brain Health Institute University of California San Francisco California USA.[Affiliation]"
Objective: The rise in dementia prevalence, particularly in lower- and middle-income countries (LMIC), places a significant burden on healthcare systems. However, comprehensive data on dementia hospital admissions are scarce.
Methods: We analyzed admission rates for dementia, cost of hospital admissions, lengths of hospital stay, and in-hospital deaths in 2010 and 2019 in Brazil.
Comorbid neuropathology and atypical presentation of Alzheimer's disease.
Alzheimers Dement (Amst)
July 2024
Introduction: Alzheimer's disease (AD) neuropathological changes present with amnestic and nonamnestic (atypical) syndromes. The contribution of comorbid neuropathology as a substratum of atypical expression of AD remains under investigated.
Methods: We examined whether atypical AD exhibited increased comorbid neuropathology compared to typical AD and if such neuropathologies contributed to the accelerated clinical decline in atypical AD.
Article Synopsis
- Asymptomatic and mildly symptomatic individuals with a genetic predisposition to Alzheimer's disease are prime candidates for trials to delay dementia onset, with brain atrophy serving as a key early indicator of risk.
- A dementia risk score was developed using gray-matter volumes from 231 participants, demonstrating a high accuracy (96.4%) in distinguishing between asymptomatic and demented individuals, and effectively predicting dementia onset within two years.
- These individualized risk scores could aid in determining trial eligibility and tailoring participants for prevention studies, enhancing the effectiveness of future research efforts.