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Global Brain Health Institute[Affiliation] Publications | LitMetric

1,305 results match your criteria: "Global Brain Health Institute[Affiliation]"

Article Synopsis
  • Poor affect recognition is an early indicator of frontotemporal dementia (FTD), and this study used the Comprehensive Affect Testing System (CATS-A) to assess emotional dysfunction in FTD patients compared to healthy controls.
  • The study involved 139 FTD patients of various subtypes and tested them alongside 116 healthy controls, measuring their Affective Recognition Quotient (ARQ) to evaluate emotional recognition accuracy.
  • Results showed that the CATS-A effectively differentiated between FTD patients and healthy controls with high accuracy (AUC 0.89) and had robust internal reliability, suggesting it's a valuable clinical tool for assessing emotional dysfunction in FTD.
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Background: Physical function deficits and frailty are commonly reported in people experiencing homelessness and addiction. Typically, geriatric, or general physical performance measures are employed to evaluate these constructs.

Objectives And Setting: We aimed to investigate the feasibility of a broad test battery to evaluate physical functioning and frailty in a non-geriatric community-based population of people experiencing homelessness and addiction.

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This study addresses the urgent need for culturally sensitive cognitive assessments in Egypt by validating an adapted version of Harmonized Cognitive Assessment Protocol (HCAP) to the Egyptian context. This version is to be used as a part of the Egyptian Aging Survey (AL-SEHA). We enrolled 300 participants aged 55 + from diverse backgrounds and meticulously adapted the HCAP for Egypt's linguistic and cultural context.

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Article Synopsis
  • - Brain Age Gap is related to dementia in older adults, but its link to dementia risk-factors and cognitive performance in middle-aged individuals is less explored.
  • - A study involving 552 cognitively healthy middle-aged participants showed that brain age gap correlates with factors like hypertension and alcohol intake, but not with genetic risk factors (like the APOE ε4 allele) or cognitive performance.
  • - Findings suggest that addressing modifiable risk factors may help in developing therapies to prevent dementia in middle-aged populations.
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Background: COVID-19-related restrictions led to an increase in overall loneliness and social isolation. Before the pandemic, care partners reported higher levels of loneliness and higher loneliness prevalence compared to non-care partners. Because of the spread and severity of the infections, and the access to support spread, we expect a different impact of the COVID-19 pandemic on LATAM care partners.

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Introduction: A growing literature has shown that exposure to adverse life events during childhood or adolescence is associated with the presence of psychotic-like experiences (PLEs), which is in turn associated with the risk of psychotic outcomes. Ruminative thinking, i.e.

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Article Synopsis
  • Individuals with subjective cognitive decline (SCD) face a higher risk of developing dementia, and the GINGER initiative presents a multicomponent lifestyle intervention approach that includes exercise as a key component for prevention and management.
  • The exercise protocol designed for GINGER targets adults over 55 with SCD and involves a structured program of aerobic, strengthening, balance, and dual-task exercises, delivered three times a week, both in group sessions and at home.
  • The implementation of this exercise protocol was found to be feasible and reliable, showing good adherence and user satisfaction, along with notable improvements in physical health outcomes among participants.
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Effects of training protocols on dancers' balance: A systematic review.

J Bodyw Mov Ther

October 2024

Department of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande Do Sul, Rio Grande do Sul, Brazil; Atlantic Fellow for Equity in Brain, Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland. Electronic address:

Background: Balance is an essential skill for dancers, it helps reduce the risk of injury, and is related to quality of performance. This systematic review aims to investigate the effects of training protocols on the balance of dancers when compared to control groups.

Methods: Interventional studies, published until January 2023, assessing balance in all levels of ballet, modern, and contemporary dancers were identified in the PubMed, Cochrane, Lilacs, Scielo, Embase, and SPORTDiscus databases.

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Multimodal investigations of structural and functional brain alterations in anorexia and bulimia nervosa and their relationships to psychopathology.

Biol Psychiatry

November 2024

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. Electronic address:

Article Synopsis
  • This study uses multi-modal MRI to investigate neurobiological differences between anorexia nervosa (AN) and bulimia nervosa (BN), revealing structural and functional brain changes linked to these eating disorders.
  • Key findings include reduced gray matter volume in specific brain regions (like the orbitofrontal cortex) and decreased cortical thickness, particularly in anorexia patients, which are associated with impulsivity and cognitive restraint regarding eating behaviors.
  • The results suggest that these brain changes affect reward processing and contribute to the persistence of eating disorder symptoms, highlighting potential targets for future treatment interventions.
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Hearing impairment alters the sound input received by the human auditory system, reducing speech comprehension in noisy multi-talker auditory scenes. Despite such difficulties, neural signals were shown to encode the attended speech envelope more reliably than the envelope of ignored sounds, reflecting the intention of listeners with hearing impairment (HI). This result raises an important question: What speech-processing stage could reflect the difficulty in attentional selection, if not envelope tracking? Here, we use scalp electroencephalography (EEG) to test the hypothesis that the neural encoding of phonological information (i.

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Article Synopsis
  • Latin America's genetic diversity offers a unique opportunity to study Alzheimer's disease (AD) and frontotemporal dementia (FTD), with a focus on identifying related genetic variations.
  • The study involved 2,162 participants from six countries who underwent extensive genomic sequencing and analysis to detect genetic factors linked to these dementias.
  • Results highlighted a mix of American, African, and European ancestries, discovered 17 pathogenic variants, and revealed specific genetic variations tied to AD and FTD inheritance patterns in affected families.
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Purpose: To develop a series of infographics providing persons with traumatic brain injury (TBI) and their circle of care with evidence-based information on sex and gender topics in TBI.

Materials And Methods: We employed an iterative participatory design engaging knowledge users, scientists, and experts in brain injury and patient education. To inform infographic content, we conducted an information needs assessment with knowledge users through semi-structured interviews and referred to our previously published evidence syntheses on TBI topics.

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Article Synopsis
  • The study examines how aging affects cerebral blood flow (CBF) in older adults by investigating changes in brain structure and partial volume effects due to brain atrophy.
  • Findings show that while there is a general decline in global gray-matter CBF as people age, some specific brain regions may actually experience increases in CBF after correcting for partial volume effects.
  • The results highlight that although age-related reductions in CBF are evident, regional differences in blood flow are more accurately captured when accounting for partial volume effects in brain imaging.
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Socio-cognitive research on bilinguals points to a moral foreign-language effect (MFLE), with more utilitarian choices (e.g., sacrificing someone to save more people) for moral dilemmas presented in the second language (L2) relative to the first language.

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Introduction: Collaborative dementia care models with care navigation, including the Care Ecosystem, improve outcomes for persons living with dementia (PLWDs) and their caregivers. The effects of continuous care over long periods have not been studied.

Methods: In this randomized clinical trial with 456 PLWD-caregiver dyads with high caregiver burden, we evaluated the cumulative 5-year treatment effect on PLWD quality of life, health care utilization, caregiver depression, self-efficacy, and burden.

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Article Synopsis
  • - Individuals caring for those with neurodevelopmental and neurocognitive disorders in Bangladesh, India, and Pakistan face significant psychosocial stress, especially amplified during the COVID-19 pandemic due to high care demands and lack of support.
  • - A study involving 245 informal carers identified three main coping styles: religiosity in Pakistan, viewing caregiving as a life path in Bangladesh, and self-care strategies in India, highlighting variations in coping mechanisms based on cultural context.
  • - The research emphasizes the urgent need for supportive resources to improve the well-being of both caregivers and those they care for, ensuring better care standards overall.
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Previous studies identified individual-level socioeconomic factors as key determinants of cognitive health. This study investigated the effect of area-based socioeconomic deprivation on cognitive outcomes in midlife to early late-life New Zealanders without cognitive impairment at baseline. Data stemmed from a subsample of the New Zealand Health, Work and Retirement Study, a cohort study on ageing, who completed face-to-face interviews and were reassessed two years later.

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Article Synopsis
  • * A study utilizing the Adolescent Brain Cognitive Development cohort revealed seven genomic regions where gene-environment interactions affect gray matter volume, tied to metabolic and inflammatory processes, as well as synaptic plasticity.
  • * The analysis highlighted that socioeconomic status, rather than family environment, plays a crucial role in how maternal education influences genetic effects on neurodevelopment, offering insights into the biological and social mechanisms involved.
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Article Synopsis
  • * The paper emphasizes the importance of addressing disparities like ageism and stigma, especially for minoritized communities, while providing examples of how PPI can be integrated throughout the research process.
  • * Recommendations for researchers include fostering collaborative relationships with communities, starting partnerships early, and ensuring that factors like choice, respect, and inclusion are prioritized.
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Frontotemporal dementia (FTD) is one of the leading causes of young-onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure.

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Sex differences in work-related traumatic brain injury: a concurrent mixed methods study employing the person-environment-occupation model.

Brain Inj

November 2024

Department of Occupational Sciences & Occupational Therapy, Rehabilitation Sciences Institute, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.

Background: Work-related traumatic brain injury (wrTBI) is considered a critical injury that can be prevented. Few studies have integrated clinical data and workers' injury narratives to inform sex-specific wrTBI prevention.

Objective: To examine sex differences in pre-injury factors and provide recommendations for primary prevention of wrTBI.

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Article Synopsis
  • - Research indicates that 12 lifestyle factors could account for up to 40% of dementia cases, but how these factors affect individuals specifically is unclear.
  • - Traditional ethical principles like beneficence and autonomy don't definitively guide whether to share these risk factors with cognitively unimpaired people in research.
  • - The authors propose evaluating the sharing of modifiable risk factors based on how changes in behavior and lifestyle can improve current brain health, rather than just predicting future dementia risk.
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