6 results match your criteria: "Glenn Biggs Institute of Alzheimer's and Neurodegenerative Diseases[Affiliation]"
Immune system-wide Mendelian randomization and triangulation analyses support autoimmunity as a modifiable component in dementia-causing diseases.
Nat Aging
October 2022
Department of Epidemiology and Public Health, University College London, London, UK.
Article Synopsis
- Immune system and blood-brain barrier dysfunction may play a role in developing Alzheimer's and other dementias, but the specific causal mechanisms are still unclear.
- Researchers conducted a Mendelian randomization study involving 1,827 related biomarkers, identifying 127 potential causal risk factors linked to amyloid-β, tau, and autoimmunity.
- Results from analyses suggest that treatment with anti-inflammatory methotrexate could reduce the risk of Alzheimer's in high-risk individuals, indicating that autoimmunity could be a modifiable factor in dementia-related diseases.
An Interprofessional Skills Workshop to Teach Family Caregivers of People Living with Dementia to Provide Complex Care.
J Interprof Educ Pract
March 2022
School of Nursing, Glenn Biggs Institute of Alzheimer's and Neurodegenerative Diseases, UT Heath, San Antonio, Antonio, San Antonio, Texas.
The purpose of this study was to evaluate the acceptability of and satisfaction with an interprofessional educational workshop to teach family caregivers of persons living with dementia to provide complex care. The workshop was developed by a team that included nursing, occupational therapy, speech-language pathology, nutrition and dental hygiene. Caregivers who attended the workshop completed an evaluation to describe their satisfaction and acceptability using a Likert-type scale, as well as open ended comments about their learning needs and feedback about the workshop.
View Article and Find Full Text PDFHerpes Labialis, Chlamydophila pneumoniae, Helicobacter pylori, and Cytomegalovirus Infections and Risk of Dementia: The Framingham Heart Study.
J Alzheimers Dis
September 2021
Glenn Biggs Institute of Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA.
Background: An association between chronic infectious diseases and development of dementia has been suspected for decades, based on the finding of pathogens in postmortem brain tissue and on serological evidence. However, questions remain regarding confounders, reverse causality, and how accurate, reproducible and generalizable those findings are.
Objective: Investigate whether exposure to Herpes simplex (manifested as herpes labialis), Chlamydophila pneumoniae (C.
Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study.
Neurology
November 2018
From the Division of Endocrinology, Diabetes and Hypertension (J.B.E.-T.), Brigham and Women's Hospital/Harvard Medical School, Boston; National Heart, Lung, and Blood Institute (J.B.E.-T., S.C.C., J.J.H., A.S.B., R.S.V., S.S.), Framingham Heart Study, MA; Department of Neurology (S.C.C., J.J.H., A.S.B., S.S.) and Sections of Preventive Medicine and Epidemiology (R.S.V.) and Cardiology (R.S.V.), Department of Medicine, Boston University School of Medicine; Departments of Biostatistics (J.J.H., A.S.B.) and Epidemiology (R.S.V.), Boston University School of Public Health, MA; Department of Neurology (P.M., C.S.D.), University of California, Davis, Sacramento; and Glenn Biggs Institute of Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio.
Objective: To assess the association of early morning serum cortisol with cognitive performance and brain structural integrity in community-dwelling young and middle-aged adults without dementia.
Methods: We evaluated dementia-free Framingham Heart Study (generation 3) participants (mean age 48.5 years, 46.
Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association.
Am J Respir Crit Care Med
March 2019
12 Center for Omics Discovery and Epidemiology, Behavioral Health Research Division, and.
Rationale: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have anti-inflammatory properties that could benefit adults with comprised pulmonary health.
Objective: To investigate n-3 PUFA associations with spirometric measures of pulmonary function tests (PFTs) and determine underlying genetic susceptibility.
Methods: Associations of n-3 PUFA biomarkers (α-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid [DPA], and docosahexaenoic acid [DHA]) were evaluated with PFTs (FEV, FVC, and FEV/FVC) in meta-analyses across seven cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (N = 16,134 of European or African ancestry).
Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies.
Alzheimers Dement
June 2018
Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Translational Epidemiology, Faculty Science, Leiden University, Leiden, The Netherlands. Electronic address:
Introduction: Identifying circulating metabolites that are associated with cognition and dementia may improve our understanding of the pathogenesis of dementia and provide crucial readouts for preventive and therapeutic interventions.
Methods: We studied 299 metabolites in relation to cognition (general cognitive ability) in two discovery cohorts (N total = 5658). Metabolites significantly associated with cognition after adjusting for multiple testing were replicated in four independent cohorts (N total = 6652), and the associations with dementia and Alzheimer's disease (N = 25,872) and lifestyle factors (N = 5168) were examined.