The role of serum biomarkers in determining systemic inflammation and cardiovascular risk in pseudoexfoliation syndrome.

Purpose: To investigate the role of hematological and atherogenic biomarkers in evaluating systemic inflammation and cardiovascular risk in patients with pseudoexfoliation syndrome.

Methods: This retrospective study included 200 patients, 90 with pseudoexfoliation (PEX) syndrome (Group 1) and 110 healthy controls (Group 2). Twelve-hour fasting blood samples were collected to measure complete blood count, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), systemic immune-inflammation index (SII) (neutrophil x platelet/lymphocyte), systemic inflammatory response index (SIRI) (neutrophil x monocyte/lymphocyte), pan-immune inflammation value (PIV) (neutrophil x platelet x monocyte/lymphocyte), C-reactive protein (CRP), uric acid, glucose, triglycerides (TG), total cholesterol, HDL, LDL, non-HDL, and triglyceride-glucose (TyG) index (Ln (TG [mg/dL] × glucose [mg/dL]/2)).

Five-Year Outcomes of Deep Sclerectomy in Pseudoexfoliation Glaucoma Compared to Primary Open-Angle Glaucoma.

: This study aimed to investigate the five-year outcomes of deep sclerectomy (DS) in patients with pseudoexfoliation glaucoma (PEXG) and primary open-angle glaucoma (POAG). : This retrospective, observational, unicentric study analyzed POAG and PEXG patients. Intraocular pressure (IOP), the number of IOP-lowering medications, peripapillary retinal nerve fiber layer (RNFL) thickness, the number of postoperative interventions, surgical success rates, and secondary surgery rates were evaluated at baseline and during follow-up appointments.

Comparison of retinal and choroidal vascular changes via optical coherence tomography angiography between Pseudoexfoliative glaucoma and Pseudoexfoliative syndrome and control group.

Background: This study aims to evaluate the differences in retinal and choroidal vasculature using optical coherence tomography angiography (OCTA) in patients with pseudoexfoliative glaucoma (PEX-G) and patients with pseudoexfoliation syndrome without glaucoma (PEX-S) and the control group.

Materials And Methods: In this cross-sectional study, 25 patients with PEX-G, 27 PEX-S cases, and 25 patients as the control group (C) were evaluated. All patients and the control group underwent macular and optic nerve head (ONH) OCTA, performed using the Optovue device.

Ahmed Glaucoma Valve Implantation in Jordan: Indications and Complications.

Aim: The main indications for Ahmed glaucoma valve (AGV) include neovascular glaucoma, congenital glaucoma, primary open angle glaucoma and patients with failed previous trabeculectomy. This article aims to investigate the complications of AGV in Jordanian glaucoma patients and to justify the main risk factors.

Methods: Retrospectively, we report 87 eyes of 83 patients who underwent AGV implantation for different indications.

Pattern of Spheroidal Degeneration of Cornea and Its Association with Other Eye Diseases at Anterior Segment Clinic in Menelik II Tertiary Referral Hospital.

Purpose: The purpose of the study was to assess the pattern of spheroidal degeneration of cornea (SDC) and its association with other eye diseases at the anterior segment clinic (ASC) in Menelik II Tertiary Referral Hospital.

Methods: A hospital-based prospective descriptive study was conducted at ASC, in Menelik II Tertiary Referral Hospital, from May 2021 to September 2022. All enrolled patients meeting the inclusion criteria were selected and assessed with a structured questionnaire.

Risk and protective factors of late in-the-bag intraocular lens dislocations - a systematic review.

Topic: This article aimed to identify and review published articles addressing risk and protective factors of late in-the-bag (ITB) intraocular lens (IOL) dislocations.

Clinical Relevance: Prevention of this complication is of great importance considering the great number of cataract cases and its vision threatening capacity.

Methods: A structured search on PubMed (MEDLINE) using both Medical Subject Headings (MeSH) and key words was conducted.

The Effect of Latanoprostene Bunod 0.024% on Optical Coherence Tomography Angiography in Newly Diagnosed Open Angle Glaucoma.

Purpose: The aim of this study was to investigate the effect of topical latanoprostene bunod 0.024% applied once daily on intraocular pressure and macular vessel density in newly diagnosed primary and pseudoexfoliative open angle glaucoma patients.

Methods: A total of 66 patients with newly diagnosed open angle glaucoma were included in this study (group 1).

Exfoliation syndrome genetics in the era of post-GWAS.

Exfoliation syndrome (XFS), or pseudoexfoliation syndrome, is considered a systemic disorder that leads to glaucoma with progressive visual field loss. A better insight into the underlying pathogenic mechanism will help diagnose the disease and prevent and slow progression. Here, we provide an overview of disease pathogenesis in the light of GWAS and multi-omics research.

Incidence of blindness in open-angle glaucoma in Sweden: a long-term follow-up study.

Background: Open-angle glaucoma (OAG) is a leading cause of irreversible blindness. There are no prospective studies on the risk of developing blindness in both eyes in individuals with definite OAG.

Methods: A total of 354 patients with newly diagnosed OAG, who had participated in four studies conducted at the Eye Department in Tierp, Sweden, from 1979 to 2006, were included in the investigation.

Evaluation of pseudoexfoliation syndrome patients with systemic immune indexes.

Purpose: The aim of this study was to investigate the level of peripheral blood systemic immune indexes in pseudoexfoliation syndrome (PXS) patients and to compare the results with healthy controls.

Methods: This study included 143 healthy controls (group 1) and 100 patients (group 2). Peripheral blood samples were collected from all participants.

Overlap syndrome: a case series and literature review of concurrent pigment dispersion and pseudoexfoliation syndromes.

Purpose Of Review: The purpose of this review is to present two cases of overlap syndrome, or concurrent pigment dispersion syndrome and pseudoexfoliation syndrome. The summary of existing literature highlights the importance of accurate diagnosis and potential treatment options of overlap syndrome.

Recent Findings: The cases describe two patients with overlap syndrome and resulting progressive glaucoma.

Clinical analysis of supraciliary effusion development following gonioscopy-assisted transluminal trabeculotomy surgery for pseudoexfoliation glaucoma.

Purpose: To investigate clinical characteristics of postoperative supraciliary effusion (SCE) development following gonioscopy-assisted transluminal trabeculotomy (GATT) in patients with pseudoexfoliation glaucoma (PEXG).

Methods: In this prospective and observational study, 64 eyes (64 patients) with PEXG were examined with spectral-domain optical coherence tomography (SD-OCT) after GATT over a 12-month follow-up. Outcomes were surgical success, intraocular pressure (IOP), best-corrected visual acuity (BCVA), number of antiglaucoma medications (AGM) and complications of the SCE (+) group with those of SCE (-) group.

Outcomes of Cataract Surgery Complicated With Zonular Dialysis: A Multicenter Comparative Study.

Purpose: To compare the visual outcomes, rate of cystoid macular edema (CME), and additional associated complications in eyes that exhibited zonular dialysis (ZD) during phacoemulsification to a reference group of uneventful phacoemulsification eyes.

Methods: A retrospective multicenter comparative database study. We pooled data from 8 United Kingdom sites between 2003 and 2015.

Postoperative Outcomes of PreserFlo MicroShunt in Patients with Exfoliation Glaucoma.

: This study aimed to evaluate the postoperative outcomes of the PreserFlo MicroShunt in Asian patients with exfoliation glaucoma. : We used the Kaplan-Meier method to analyze 29 eyes of 29 patients with exfoliation glaucoma (mean age: 80.7 ± 8.

Reverse Pupillary Block after Implantation of a Sutureless Scleral Fixation Carlevale Intraocular Lens.

Purpose: To describe the incidence, complications and management of reverse pupillary block (RPB) after implantation of Carlevale intraocular lens (IOL).

Design: Multicenter, retrospective, cross-sectional study.

Participants: Of a sample of 128 patients that had undergone Carlevale IOL implantation, 19 patients were found to present RPB.

Pseudophakic cystoid macular oedema and posterior capsular opacification rates after combined phaco-trabeculectomy vs. phaco alone.

Purpose: To assess the risk for pseudophakic cystoid macular oedema (PCME) and posterior capsular opacification (PCO) associated with combined cataract surgery and trabeculectomy compared to cataract surgery alone.

Methods: Data analysis of subjects who underwent routine cataract surgery without and with concomitant trabeculectomy at the Department of Ophthalmology, Bristol Eye Hospital, the UK, between January 2008 and December 2017. Odds ratios (ORs) for PCME between the types of surgeries were calculated using univariate and multivariate regression analysis.

Evaluation of lamina cribrosa parameters, nerve fiber thickness, and macular thickness in primary open-angle glaucoma and pseudoexfoliation glaucoma using optical coherence tomography.

Purpose: To evaluate the lamina cribrosa, retinal nerve fiber layer (RNFL), and macula in patients with primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PEXG) and healthy individuals using enhanced depth imaging (EDI) of spectral-domain optical coherence tomography (SD-OCT).

Methods: A total of 158 eyes were included in the study, comprising 58 eyes of 29 patients with POAG, 50 eyes of 25 patients with PEXG, and 50 eyes of 25 healthy individuals. The lamina cribrosa thickness (LCT) (at three locations), lamina cribrosa depth (LCD), RNFL thickness, and the macular thickness were measured using the EDI mode of the SD-OCT.

Corneal and anterior segment parameters in patients with clinically unilateral pseudoexfoliation syndrome.

Background: Pseudoexfoliation syndrome (PES) is an age-related systemic condition that predominantly affects ocular structures and is characterized by the deposition of material on the lens, ciliary body, zonules, corneal endothelium, iris, and pupillary margin. We compared the corneal endothelial morphology, anterior segment parameters, corneal densitometry, and corneal topographic characteristics between the clinically affected and apparently normal fellow eyes of patients with clinically unilateral PES.

Methods: This was a comparative, cross-sectional study of 34 patients with clinically unilateral PES.

Anterior segment parameters after trabeculectomy in pseudoexfoliation glaucoma versus primary open-angle glaucoma.

Background: The effects of trabeculectomy on anterior segment parameters have been widely investigated. However, the stabilization time for various glaucoma types after trabeculectomy remains debatable. We investigated the effect of mitomycin C-augmented trabeculectomy on ocular anterior segment parameters in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG) during short-term follow-up using the Pentacam HR.

Intraocular Pressure Response in the Untreated Contralateral Eye After Selective Laser Trabeculoplasty.

Aim: To examine the impact of selective laser trabeculoplasty (SLT) on intraocular pressure (IOP) in the untreated contralateral eye within 12 months after the procedure.

Methods: A retrospective chart review was conducted on patients with primary open-angle, normal-tension, pigmentary, or pseudoexfoliation glaucoma who received 360-degree SLT at George Washington University. Exclusion criteria included prior or subsequent laser or glaucoma surgery within 12 months of SLT, other glaucoma types, or corticosteroid use during follow-up.