3,824 results match your criteria: "Glasgow Caledonian University.[Affiliation]"

' (HTSAL) was a mass media campaign on drug-related death prevention which ran in Scotland from August 2021 to January 2022. It aimed to increase awareness of how to respond to an opioid overdose, and the uptake of take-home naloxone (THN). The objective of this study was to determine the reach and engagement with the campaign.

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Dysregulation of lipid metabolism in the liver of Tspo knockout mice.

Biochim Biophys Acta Mol Cell Biol Lipids

January 2025

Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow G4 0BA, United Kingdom; Department of Vision Science, Glasgow Caledonian University, Glasgow G4 0BA, United Kingdom. Electronic address:

Article Synopsis
  • The translocator protein (TSPO) is located in the outer mitochondrial membrane and affects lipid metabolism and mitochondrial function.
  • In experiments comparing wild-type and Tspo knockout mouse livers, KO mice showed increased levels of cholesterol, triglycerides, and phospholipids, alongside downregulated genes involved in cholesterol homeostasis.
  • Analysis revealed that the KO mice had altered protein expression networks, indicating TSPO's role in lipid metabolism, detoxifying reactive oxygen species, and influencing mitochondrial signaling pathways.
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Monitoring patient safety in high-risk mental health environments is a challenge for clinical staff. There has been a recent increase in the adoption of contactless sensing solutions for remote patient monitoring. mmWave radar is a technology that has high potential in this field due it its low cost and protection of privacy; however, it is prone to multipath reflections and other sources of environmental noise.

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Background: Despite the observed associations of personality traits with levels of moderate-to-vigorous physical activity (MVPA) and sedentary behavior (SB), studies exploring whether the personality profiles differ in terms of the pattern of accumulation of physical behavior are lacking. The aim of this study was to identify adults' personality profiles and to characterize and investigate how these profiles differ in physical behavior.

Methods: The study utilized the longitudinal data of the participants of the Jyväskylä Longitudinal Study of Personality and Social Development (n = 141-307).

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Background: Reduced walking ability, especially decreased gait speed, is one of the most common and disabling impairments reported by people with multiple sclerosis (MS). Considering the impact of muscle strength on walking ability, resistance training may have the potential to improve walking speed in MS. Therefore, this systematic review and meta-analysis aims to evaluate the effect of lower limb resistance training on walking speed in people with MS.

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Understanding the mental health of LGBTQIA+ communities in Western Countries: what can nurses do to help?

Evid Based Nurs

September 2024

Department of Nursing and Community Health and ReaCH (Research Center for Health), School of Health and Life Sciences, Glasgow Caledonian University (GCU), Glasgow, UK

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Article Synopsis
  • Researchers studied strokes from 1990 to 2021 to understand how many people get them and how they are affected around the world.
  • In 2021, strokes caused about 7.3 million deaths and were a major cause of health problems, especially in specific regions like Southeast Asia and Oceania.
  • There are differences in stroke risks based on where people live and their age, and some areas actually saw more strokes happening since 2015.
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Hate-motivated behavior (HMB) ranges from microaggressions to criminal acts and is a public health concern with consequences for the physical and mental well-being of individuals, families, and communities. The Hate-Motivated Behavior Checklist (HMBC) was developed with the goal of advancing the measurement of HMB perpetration. To provide insights into perpetration and victimization across the HMB continuum in Scotland, the present study sought to examine the factor structure of both the original HMBC and our adapted victimization version in a sample of adults currently living in Scotland.

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Background: Including structural determinants (e.g. criminalisation, stigma, inequitable gender norms) in dynamic HIV transmission models is important to help quantify their population-level impacts and guide implementation of effective interventions that reduce the burden of HIV and inequalities thereof.

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  • This study aimed to create a comprehensive consensus on managing myopia in children and young people across the UK and Ireland through a Delphi method involving 34 expert optometrists and ophthalmologists.
  • The panel agreed on 131 statements, emphasizing the need for parental discussions on interventions for myopia developed before age 13, publicly funded options for those at risk, and the consideration of individual hobbies and lifestyles in choosing treatment.
  • Future research is essential to better identify at-risk patients, assess the effectiveness of treatments, and adapt management strategies as new evidence arises.
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Current approaches to activity-assisted living (AAL) are complex, expensive, and intrusive, which reduces their practicality and end user acceptance. However, emerging technologies such as artificial intelligence and wireless communications offer new opportunities to enhance AAL systems. These improvements could potentially lower healthcare costs and reduce hospitalisations by enabling more effective identification, monitoring, and localisation of hazardous activities, ensuring rapid response to emergencies.

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Purpose: To explore the meaning of community reintegration and strategies for promoting community reintegration based on the lived experiences of individuals with spinal cord injury in northwest Nigeria.

Material And Methods: Using a qualitative description, we purposively recruited people with spinal cord injury residing in Kano, Nigeria. Eight focus groups were conducted to gather relevant information about the meaning and strategies for community reintegration, based on the lived experiences of the participants.

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Aims: The study aimed to synthesize evidence of daily physical activity (PA) following Behavior-change technique (BCT)-based interventions compared to any control in individuals with peripheral arterial disease/intermittent claudication (PAD/IC); and examine the relationship between BCTs and daily PA.

Methods: Systematic search of 11 databases from inception to 30/11/2022 was conducted, plus weekly email alerts of new literature until 31/8/2023. Studies comparing BCT-based interventions with any control were included.

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Article Synopsis
  • After a stroke, many people feel depressed or anxious, and this can make recovery harder.
  • A new program called HEADS: UP was created to help stroke survivors manage their feelings and improve their mental health.
  • Two studies tested this program, one in-person and one online, to see if it was easy to use and helpful for the participants.
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Implementing changing behaviour towards aerobic and strength exercise: Results of a randomised, phase I study determining the safety, feasibility, and consumer-evaluation of an online exercise program in persons with multiple sclerosis.

Contemp Clin Trials

November 2024

School of Allied Health (Exercise Science), Murdoch University, Murdoch, WA, Australia; Centre for Healthy Aging, Murdoch University, Murdoch, WA, Australia; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Murdoch, WA, Australia; Perron Institute for Neurological and Translational Science, Perth, WA, Australia. Electronic address:

Background: Many people with MS do not meet the recommended exercise regime to elicit health benefits. This study aimed to determine the feasibility, safety, acceptability, and appropriateness of an exercise intervention delivered online to persons with MS that meets current exercise recommendations and behaviour change principles.

Methods: Seventy-two participants (age: 43.

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Background: There is a growing investment in the use of co-creation, reflected by an increase in co-created products, services, and interventions. At the same time, a growing recognition of the significance of co-creators' experience can be detected but there is a gap in the aggregation of the literature with regard to experience. Therefore, the purpose of this scoping review is to uncover the breadth of existing empirical research on co-creation experience, how it has been defined and assessed, and its key emotional and psychological characteristics in the context of co-created products, services, or interventions among adults.

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Generating pooled quality control samples of volatile organic compounds.

J Breath Res

September 2024

Division of Immunology, Immunity to Infection and Respiratory Medicine; School of Biological Sciences; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Untargeted analysis of volatile organic compounds (VOCs) from exhaled breath and culture headspace are influenced by several confounding factors not represented in reference standards. In this study, we propose a method of generating pooled quality control (QC) samples for untargeted VOC studies using a split-recollection workflow with thermal desorption tubes. Sample tubes were desorbed and split from each sample and recollected onto a single tube, generating a pooled QC sample.

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Objectives: The overall aim of the current study was to quantify physical activity levels in inflammatory rheumatic diseases (IRDs) and to explore their role in fatigue.

Methods: We conducted a secondary analysis of data from the Lessening the Impact of Fatigue in IRDs (LIFT) trial of the personalized exercise program (PEP) intervention for fatigue. Participants with IRDs were recruited from 2017 to 2019 and the current analysis used fatigue, measured by the Chalder Fatigue Scale (CFS) and the Fatigue Severity Scale (FSS), and accelerometer measured physical activity data collected at baseline and at the 6-month follow-up.

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Purpose: The aim of this study is to explore the feasibility of using machine learning approaches to objectively differentiate the mobilization patterns, measured via accelerometer sensors, of patients pre- and post-intervention.

Methods: The intervention tested the implementation of a Frailty Care Bundle to improve mobilization, nutrition and cognition in older orthopedic patients. The study recruited 120 participants, a sub-group analysis was undertaken on 113 patients with accelerometer data (57 pre-intervention and 56 post-intervention), the median age was 78 years and the majority were female.

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Article Synopsis
  • To track global progress in reducing HIV incidence, a reliable evaluation method is essential since usual HIV diagnosis dates can misrepresent when the infection actually occurred.
  • A Bayesian statistical model was developed to more accurately estimate the proportions of recent and incident HIV infections in Scotland from 2015 to 2019 by incorporating various testing results and surveillance data.
  • The model found that 43.9% of diagnoses were incident infections and 21.6% were recent, particularly high among people who inject drugs, demonstrating the model's potential to enhance understanding of HIV transmission dynamics amidst data limitations.
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Objectives: To review and evaluate available literature on spectral computed tomography (SCT) bone mineral density (BMD) measurement in adult thoracolumbar vertebrae of unenhanced images compared to quantitative computed tomography (QCT), to understand its current clinical utility.

Key Findings: Keyword searches in four databases identified four cross-sectional studies which acquired an SCT BMD measurement in thoracolumbar vertebrae and compared this respectively to QCT, which were then critically appraised using the AXIS tool for cross-sectional studies. 862 vertebrae were measured between T10-S1 in 368 patients.

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Objectives: Partner notification (PN) is a key component of sexually transmitted infection control. British Association for Sexual Health and HIV guidelines now recommend partner-centred PN outcomes using a five-category partner classification (established, new, occasional, one-off, sex worker). We evaluated the reporting of partner-centred PN outcomes in two contrasting UK sexual health services.

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The Benchmarking Exercise Programme for Older People (BEPOP): Design, Results and Recommendations from The First Wave of Data Collection.

J Frailty Sarcopenia Falls

September 2024

AGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.

Objectives: The Benchmarking Exercise Programme for Older People (BEPOP) service improvement project seeks to determine and promote the exercise training characteristics associated with positive outcomes for resistance exercise for older people living with, or at risk of, sarcopenia or physical frailty.

Methods: Mixed-methods service improvement project. Ten UK National Health Service physiotherapist-led therapy services delivering exercise interventions for older people submitted anonymized data for up to 20 consecutive patients.

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