3,341 results match your criteria: "Gifu University Graduate School[Affiliation]"
Coexistence of Spontaneous Pneumomediastinum and a Parapharyngeal Space Tumor: A Case Report of a Patient Initially Referred for Descending Necrotizing Mediastinitis.
Cureus
September 2024
Head and Neck Surgery-Otolaryngology, Ogaki Municipal Hospital, Ogaki, JPN.
Spontaneous pneumomediastinum is conventionally defined as a disease that does not result from trauma or underlying disease. In recent years, many patients have had some kind of triggering factor, such as sports or a strong cough. Herein, we report a case of mediastinal emphysema with a parapharyngeal tumor at the time of initial examination.
View Article and Find Full Text PDFThe Impact of Listening to Background Music on Inhibition Control and Prefrontal Cortical Activation in Healthy Older Adults: A Study Using Functional Near-Infrared Spectroscopy.
Cureus
September 2024
Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Chubu Neurorehabilitation Hospital, Minokamo, JPN.
Introduction Aging declines executive functions, including attentional function and inhibitory control, which is the ability to inhibit inappropriate or irrelevant responses. Certain types of background music are negatively correlated with cognitive function. The prefrontal network is correlated with task performance related to executive function.
View Article and Find Full Text PDFEffect and mechanisms of cyclophosphamide-induced ovarian toxicity on the quality of primordial follicles with respect to age at treatment initiation.
Reprod Biol
December 2024
Department of Obstetrics and Gynecology, Gifu University Hospital, Gifu 501-1194, Japan.
Chemotherapy-induced ovarian toxicity in patients with cancer significantly affects future fertility depending on the age of initiation of treatment. However, the mechanisms underlying the age-related depletion of the ovarian reserve are not well understood. We investigated the effects of chemotherapy on pre- and postpubertal ovarian reserves in a mouse model.
View Article and Find Full Text PDFCopy number variations in RNF216 and postsynaptic membrane-associated genes are associated with bipolar disorder: a case-control study in the Japanese population.
Psychiatry Clin Neurosci
January 2025
Pathophysiology of Mental Disorders, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Article Synopsis
- - The study investigates the link between rare copy number variations (CNVs) in synaptic genes and bipolar disorder (BD) in a Japanese population, using genome hybridization techniques on nearly 2,000 BD patients and 2,760 controls.
- - Results indicate a strong association between the RNF216 gene and BD, with significant findings also related to postsynaptic membrane components, suggesting these genetic factors contribute to BD risk.
- - The findings enhance understanding of BD's genetic underpinnings, highlighting the importance of CNVs in gene regions that may influence the disorder's development.
Endoscope-assisted treatment for delayed cystic radiation necrosis after stereotactic radiosurgery for metastatic brain tumors: illustrative cases.
J Neurosurg Case Lessons
October 2024
Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan.
Article Synopsis
- Cystic radiation necrosis, resulting from radiation therapy for metastatic brain tumors, can require surgical intervention when symptoms arise, making excision of necrotic tissue crucial to avoid recurrence.
- Neuroendoscopic surgery is presented as a minimally invasive technique that allows for effective treatment of these cystic formations by accessing deep brain lesions without extensive procedures.
- In two patient cases, this method successfully removed radiation necrotic tissue, leading to rapid cyst shrinkage and resolution of symptoms, demonstrating the effectiveness of endoscopic surgery for this condition.
Concomitant heparin use promotes skin graft donor site healing by basic fibroblast growth factor: A pilot prospective randomized controlled study.
Contemp Clin Trials Commun
December 2024
Department of Otolaryngology-Head and Neck Surgery, Gifu University Graduate School of Medicine, Gifu, Japan.
Owing to its mitogenic and angiogenic characteristics, the use of basic fibroblast growth factor (bFGF) to promote wound healing has been investigated. However, its clinical efficacy has fallen short of expectations due to its instability. Heparin has been reported to stabilize bFGF.
View Article and Find Full Text PDFPostoperative pathological findings and prognosis of early laryngeal and pharyngeal cancer treated with transoral surgery.
Auris Nasus Larynx
December 2024
Department of Otolaryngology-Head and Neck Surgery, Gifu University Graduate School of Medicine, Japan.
Article Synopsis
- Transoral surgery is effective for early-stage pharyngeal and laryngeal cancer, offering good local control with less invasiveness compared to external incisions, but criteria for postoperative treatment remain unclear.
- In a study of 70 patients at Gifu University Hospital, high rates of positive surgical margins were found (38.6% horizontal, 27.1% vertical), yet overall survival rates were strong, with 77.1% surviving five years post-surgery.
- Horizontal margin positivity correlated with worse outcomes, while vascular invasion wasn't significantly linked to prognosis, indicating a need for more research to establish clear postoperative treatment guidelines.
Popliteal plexus block compared with tibial nerve block on rehabilitation goals following total knee arthroplasty: a randomized non-inferiority trial.
Sci Rep
October 2024
Department of Anesthesiology and Intensive Care Medicine, Daiyukai General Hospital, 1-9-9, Sakura, Ichinomiya, Aichi, 491-8551, Japan.
Article Synopsis
- * Both techniques showed similar times to reach rehabilitation goals, with PPB at around 47.4 hours and TNB at 49.7 hours, indicating that PPB is non-inferior to TNB.
- * PPB demonstrated better preservation of foot motor strength compared to TNB, while both groups had no significant differences in pain levels or other rehabilitation metrics.
Evaluating the Safety of Stent-Assisted Endovascular Treatment for Unruptured Cerebral Aneurysms in Older Adults: Emphasizing the Role of Antiplatelet Therapy.
Cerebrovasc Dis
October 2024
Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan.
Article Synopsis
- The study compared outcomes and safety in patients aged ≥75 years versus those aged <75 years undergoing stent-assisted treatment for unruptured cerebral aneurysms, focusing on antiplatelet therapy.
- Among 632 patients, the primary outcomes (thromboembolic events, bleeding, or death) showed no significant differences between the two age groups, with similar rates of events over time.
- The findings suggest that age alone should not be a strict criterion against stent-assisted treatment for unruptured aneurysms.
Ultrasensitive detection of TDP-43 and amyloid-β protein aggregates using micelle-assisted seed amplification assay.
Transl Neurodegener
October 2024
United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan.
Differences in vascular tissue response after stent implantation between biolimus-eluting and everolimus-eluting stents: a sub-study of the NEXT study.
Heart Vessels
October 2024
Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan.
Article Synopsis
- - The NEXT trial compared the Nobori biolimus-eluting stent (BES) and the XIENCE/PROMUS everolimus-eluting stent (EES) by analyzing data from 3,235 patients over 8-12 months at 18 centers.
- - Researchers examined various cross-sections before and after stent implantation, measuring volume changes in different tissue types at plaque sites, finding no significant differences in vascular response between the two stent types after 8 months.
- - Despite the lack of significant findings and the trial being underpowered for comprehensive statistical analysis, the results indicated similar vascular tissue reactions for both stents, despite differences in material and thickness.
Clinical impact of intraoperative pancreatic transection margin analysis and additional resection during pancreaticoduodenectomy for pancreatic ductal adenocarcinoma.
Pancreatology
November 2024
Department of Surgical Oncology and Pediatric Surgery, Gifu University Graduate School of Medicine, Japan.
Article Synopsis
- The study investigates the effects of intraoperative frozen section analysis (FSA) of pancreatic transection margins on the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC).
- A total of 311 patients who underwent pancreaticoduodenectomy were analyzed, with findings categorized into three groups based on the first FSA results: negative (1FSA-R0), carcinoma in situ (1FSA-CIS), and invasive carcinoma (1FSA-IC).
- Results showed similar median survival rates for 1FSA-R0 and 1FSA-CIS, indicating that additional resections may be justified for 1FSA-CIS, while 1FSA-IC was significantly associated with poorer survival
A case of revertant mosaic-like normal-looking spots in a patient with erythroderma with IL36RN and CARD14 heterozygous mutations.
J Dermatol
December 2024
Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
Article Synopsis
- An 89-year-old woman from Japan had a skin condition that made her skin very red and scaly.
- Doctors found some unusual changes in her skin cells and discovered she had mutations in two specific genes (IL36RN and CARD14).
- She later developed small, round spots on her skin that looked normal, but tests showed these spots might be different from her red, scaly skin despite having the same gene mutations.
Age at menarche by birth cohort: A pooled analysis of half a million women in Asia.
Public Health
December 2024
Division of Prevention, National Cancer Center Institute for Cancer Control, Japan.
Article Synopsis
- * Researchers found that the average age girls start their periods is about 14 years, but it has been getting younger over the past 100 years.
- * Different countries showed different trends, with some like China having ups and downs, while others like Japan and Singapore had a steady decline in the average age.
Response to letter to the editor regarding: "Alcohol-associated liver disease increases the risk of muscle reduction and mortality in patients with cirrhosis".
J Gastroenterol
December 2024
Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
Dietary habits and genetic susceptibility: correlations between nutritional intake and genetic risks for schizophrenia and bipolar disorder.
Transl Psychiatry
October 2024
Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan.
Article Synopsis
- The study explores how dietary habits may influence the prevention and management of schizophrenia (SCZ) and bipolar disorder (BD) in older adults, particularly in relation to genetic predispositions and lifestyle-related diseases.
- A cohort of 730 older patients was assessed for their dietary habits across various food categories while calculating polygenic risk scores (PRSs) for SCZ and BD based on large-scale genetic studies.
- Findings indicated that higher genetic risk for SCZ and BD is correlated with lower consumption of nutrient-rich foods like light-colored vegetables and soybeans, with notable differences in dietary impacts between types of BD, especially BD I.
ASO Author Reflections: Can Conversion Therapy be an Option for Advanced Esophageal Cancer with Distant Metastases?
Ann Surg Oncol
January 2025
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
Quality of Life in Japanese People with Type 2 Diabetes Switching from Multiple Daily Insulin Injections to Once-Daily iGlarLixi: SIMPLIFY Japan.
Diabetes Ther
November 2024
Department of Diabetes, Endocrinology and Metabolism, and Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Gifu, Japan.
Article Synopsis
- The SIMPLIFY Japan study examined the transition from multiple daily insulin injections to once-daily iGlarLixi in adults with moderately controlled type 2 diabetes (T2D).
- Over 24 weeks, participants showed significant improvements in health-related quality of life (HRQOL) scores, particularly in areas related to daily activities and treatment satisfaction, with minimal negative impact on glycemic control.
- Additionally, there was an increase in treatment adherence and a small weight reduction, but incidences of hypoglycemia and gastrointestinal side effects were noted among participants.
SOX17 expression in tumor endothelial cells in colorectal cancer and its association with favorable outcomes in patients.
Pathol Res Pract
November 2024
Department of Pathology and Translational Research, Gifu University Graduate School of Medicine, Gifu, Japan; Center for One Medicine Innovative Translational Research, COMIT, Gifu University, Gifu, Japan. Electronic address:
The high mortality rate of colorectal cancer (CRC) highlights the need for new treatment strategies; however, the venous invasion mechanisms in tumor endothelial cells within CRC remain unexplored. Therefore, we investigated the clinicopathological features of SRY-box transcription factor 17 (SOX17) in CRC. Immunohistochemical staining was performed on 55 CRC tissue specimens using a SOX17-specific antibody, followed by Kaplan-Meier and Cox proportional hazards regression analyses.
View Article and Find Full Text PDFStudy protocol of the ASTOP trial: A multicenter, randomized, double-blind, placebo-controlled trial of presurgical aspirin administration for the prevention of thromboembolic complications of coil embolization for ruptured aneurysms.
PLoS One
September 2024
Department of Endovascular Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Article Synopsis
- Thromboembolism is a critical concern in patients undergoing endovascular treatment for ruptured cerebral aneurysms, and administering antiplatelet agents like aspirin before the procedure may lower this risk.
- The study, called ASTOP, is a multicenter, randomized, double-blind trial involving 484 patients, comparing the effects of 200 mg of aspirin versus a placebo prior to treatment.
- Primary outcomes will focus on measuring thromboembolic complications and ischemic lesions during the procedure, while secondary outcomes will assess cerebral ischemic events, bleeding incidents, and patient functional status after 90 days.
CVIT expert consensus document on primary percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS) in 2024.
Cardiovasc Interv Ther
October 2024
Department of Cardiology, Teikyo University Hospital, Tokyo, Japan.
Primary Percutaneous Coronary Intervention (PCI) has significantly contributed to reducing the mortality of patients with ST-segment elevation myocardial infarction (STEMI) even in cardiogenic shock and is now the standard of care in most of Japanese institutions. The Task Force on Primary PCI of the Japanese Association of Cardiovascular Intervention and Therapeutics (CVIT) proposed an expert consensus document for the management of acute myocardial infarction (AMI) focusing on procedural aspects of primary PCI in 2018 and updated in 2022. Recently, the European Society of Cardiology (ESC) published the guidelines for the management of acute coronary syndrome in 2023.
View Article and Find Full Text PDFGenetic overlap between schizophrenia spectrum disorders and Alzheimer's disease: Current evidence and future directions - An integrative review.
Neurosci Biobehav Rev
December 2024
Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan.
Article Synopsis
- * Patients with schizophrenia or delusional disorder, especially older women, are at a higher risk for developing Alzheimer's, while a significant percentage of Alzheimer's patients experience psychotic symptoms that can worsen their condition.
- * The review highlights weak genetic correlations between schizophrenia and Alzheimer's, pointing out inconsistencies in polygenic risk scores, and underscores the need for further research into their genetic links and impacts on treatment and prevention strategies.
Gravitational change-induced alteration of the vestibular function and gene expression in the vestibular ganglion of mice.
J Physiol Sci
September 2024
Department of Physiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
Article Synopsis
- This study investigates how the vestibular system in mice adapts to changes in gravity, focusing on hypergravity conditions (2 G) and normal gravity (1 G).
- Male C57BL/6J mice were tested for vestibular function and gene expression after exposure to higher gravity, revealing significant dysfunction that lasted for several days but improved once back to normal gravity.
- Analysis identified changes in 212 genes, with 25 genes increasing in expression under hypergravity and reverting to baseline after returning to normal gravity, highlighting specific genes important for neural function and adaptation to gravitational changes.
Successful treatment of DRESS with narrowband UVB phototherapy.
J Dtsch Dermatol Ges
December 2024
Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
Targeted therapy guided by circulating tumor DNA analysis in advanced gastrointestinal tumors.
Nat Med
September 2024
Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Article Synopsis
- - Comprehensive genomic profiling using circulating tumor DNA (ctDNA) has potential in capturing tumor diversity and improving therapy choices, but it's not fully utilized in clinical settings, especially for advanced solid tumors.
- - The GOZILA study found that ctDNA profiling led to a 24% match rate for targeted therapies, significantly improving patient outcomes, with those receiving matched treatments experiencing better overall survival rates compared to those who were unmatched.
- - Key ctDNA characteristics, like biomarker clonality and plasma copy number, serve as indicators of treatment effectiveness, suggesting that ctDNA can enhance precision in oncology and should be more widely used to optimize patient survival in advanced solid tumors.