Fused Deposition Modeling 3D-Printed Scaffolds for Bone Tissue Engineering Applications: A Review.

The emergence of bone tissue engineering as a trend in regenerative medicine is forcing scientists to create highly functional materials and scaffold construction techniques. Bone tissue engineering uses 3D bio-printed scaffolds that allow and stimulate the attachment and proliferation of osteoinductive cells on their surfaces. Bone grafting is necessary to expedite the patient's condition because the natural healing process of bones is slow.

An Invasive Ductal Carcinomas Breast Cancer Grade Classification Using an Ensemble of Convolutional Neural Networks.

Invasive Ductal Carcinoma Breast Cancer (IDC-BC) is the most common type of cancer and its asymptomatic nature has led to an increased mortality rate globally. Advancements in artificial intelligence and machine learning have revolutionized the medical field with the development of AI-enabled computer-aided diagnosis (CAD) systems, which help in determining diseases at an early stage. CAD systems assist pathologists in their decision-making process to produce more reliable outcomes in order to treat patients well.

Integrating Morphological Edge Detection and Mutual Information for Nonrigid Registration of Medical Images.

Background: Medical images are widely used within healthcare and medical research. There is an increased interest in precisely correlating information in these images through registration techniques for investigative and therapeutic purposes. This work proposes and evaluates an improved measure function for registration of carotid ultrasound and magnetic resonance images (MRI) taken at different times.

Recent insights into synthetic β-carbolines with anti-cancer activities.

Cancer, an uncontrolled and rapid proliferation of abnormal cells, has become one of the leading cause of death worldwide. The development of resistance among the numerous drugs in clinical use has provided strong impetus for the identification and development of novel cancer therapeutics. β-carbolines constitute an important class of pharmacologically active scaffolds known to exert their anticancer activities via diverse mechanisms.

1H-1,2,3-triazole-tethered uracil-ferrocene and uracil-ferrocenylchalcone conjugates: Synthesis and antitubercular evaluation.

Copper-catalyzed azide-alkyne [3 + 2] cycloaddition has been utilized for preparing a series of 1H-1,2,3-triazoles with the purpose of probing structure-activity relationships among a uracil-ferrocene-triazole conjugate family. The antitubercular evaluation studies revealed an improvement in activity with the introduction of a ferrocene nucleus among N-alkylazido-uracil precursors, with a preference for a bromo-substituent along with moderate chain lengths of n = 2-6. The reported protocol is a successful approach for integrating uracil-ferrocene-chalcone functionalities tethered via 1H-1,2,3-triazole rings with apparent physicochemical stability.