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Protective effect of Panax ginseng in cisplatin-induced cachexia in rats.

Future Oncol

May 2014

Giancarlo Colombo Neuroscience Institute, National Research Council of Italy, Section of Cagliari, S.S. 554, km. 4,500 I-09042 Monserrato (CA), Italy.

Aim: This study investigated the protective effect of a standardized extract of Panax ginseng on multiple cisplatin-induced 'sickness behaviors' (model of cancer-induced cachexia) in rats.

Materials & Methods: Cisplatin was administered twice weekly (1-2 mg/kg, intraperitoneal) for 5 consecutive weeks. Panax ginseng extract (0, 25 and 50 mg/kg, intragastric) was administered daily over the 5-week period of cisplatin exposure.

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