1 results match your criteria: "Ghent University Hospital (Department of Endocrinology[Affiliation]"
Evaluation of the thiazide challenge test to differentiate primary from hypercalciuria-related hyperparathyroidism.
J Clin Endocrinol Metab
April 2024
Ghent University Hospital (Department of Endocrinology, Unit for Osteoporosis and Metabolic Bone Diseases).
Article Synopsis
- The study focuses on differentiating primary hyperparathyroidism (PHPT) from secondary hyperparathyroidism due to idiopathic hypercalciuria (SHPT-IH) using the thiazide challenge test (TCT), highlighting the lack of robust diagnostic tools.
- Conducted at Ghent University Hospital, the observational study monitored 25 adult patients exhibiting hypercalciuria and elevated parathyroid hormone levels who underwent the TCT.
- Results indicated that PHPT patients demonstrated significantly higher increases in serum calcium than SHPT-IH patients, with the TCT achieving 81.8% sensitivity and 77.8% specificity, suggesting it is a helpful tool for clinical decision-making in distinguishing these conditions.